Protective effects of polysaccharides from Panax ginseng on acute gastric ulcers induced by ethanol in rats

Abstract

Panax ginseng is a traditional medicine used in China to cure many diseases. Polysaccharide is the primary active component. It has many pharmacological effects. Gastric ulcer is one of the...

Tricholoma matsutake-Derived Peptides Show Gastroprotective Effects against Ethanol-Induced Acute Gastric Injury

“…Ethanol is known to cause acute gastric mucosal damage in mice, resulting in visible black corrosive lesions, severe vascular obstruction, and inflammation of the gastric tissue. 17 To determine the protective effects of SDIKHFPPF and SDLKHFPF against ethanol-triggered acute stomach damage in mice, we established an absolute ethanol-triggered acute gastric injury model (Figure 2A). The changes in body weight are presented in Figure 2B; as the number of experimental days increased, the body weight of each group increased, showing no significant differences.…”

Investigation on the Effects and Mechanisms of Alkaline Natural Mineral Water and Distilled Water on Ethanol-Induced Gastric Ulcers In Vivo and In Vitro

“…MDA is an important product of lipid peroxidation reaction, which can usually indirectly reflect the degree of lipid peroxidation reaction and cell damage in vivo. It also leads to cross-linked polymerization of proteins, nucleic acids, and other living macromolecules [20]. The results of this study showed that compared with DWM group, these biochemical parameters in group AWM had no significant improvement (p > 0.05), suggesting that alkaline natural mineral water could not alleviate gastric ulcers by regulating antioxidant enzyme system in the body.…”

Comparisons of Isolation Methods, Structural Features, and Bioactivities of the Polysaccharides from Three Common Panax Species: A Review of Recent Progress

“…The proposed structure of a low-molecular weight polysaccharide of ginseng, MCGP-L, was clearly elucidated by monosaccharide composition and methylation analyses and NMR spectroscopy [ 55 ]. Furthermore, different ranges of molecular weight, various monosaccharide compositions, HG backbone with hairy regions of RG-I, α-dominating configurations, and (1→)- or (1→6)- and (1→3)-glycosidic linkages were found in other ginseng polysaccharides extracted by hot water [ 27 , 34 , 36 , 52 , 54 , 67 , 68 , 69 , 70 ]. It was determined that RG-I, xylan, and xyloglucan are major components in ginseng polysaccharides sequentially extracted by Na 2 CO 3 [ 37 ].…”

“…GPS promoted food intake in mice, which may be related to appetite-regulation peptides and circulating glucose levels [ 119 ]. In an ethanol-induced gastrically injured rat model, GPS increased anti-oxidant activity and suppressed inflammation [ 27 ]. In a diarrhea mouse model induced by antibiotics, a ginseng polysaccharide named WGP changed the gut microbiota composition and diversity and balanced metabolic processes to recover the mucosal structure [ 69 ].…”

“…At present, approximately 200 active substances in these three species have been discovered, including saponins [ 6 , 7 , 8 ], polysaccharides [ 9 , 10 ], oligosaccharides [ 11 , 12 ], polyacetylenes [ 13 , 14 ], peptides [ 15 , 16 ], and bioactive proteins [ 17 ]. Polysaccharides are the main active components and have demonstrated diverse pharmacological functions, such as anti-tumor [ 18 , 19 ], immune system modulation [ 20 , 21 , 22 , 23 ], anti-oxidant [ 24 , 25 ] and anti-aging [ 26 ] activities, as well as others [ 27 , 28 ].…”