Protective effects of polydatin on LPS-induced endometritis in mice

Li, Rong; Maimai, T.; Yao, Hongmei; Liu, Xueshibojie; He, Zhaoqi; Xiao, Chong; Wang, Yinan; Xie, Guanghong

doi:10.1016/j.micpath.2019.103720

Cited by 16 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, it was inferred that HKL may also confer beneficial effects on inflammation in endometritis. Lipopolysaccharide (LPS) is a classic endotoxin that has been used widely in inflammatory model establishment, including the establishment of an endometritis model ( 7 , 14 ). In particular, HKL has been demonstrated to exert protective effects against LPS-induced inflammation in the respiratory system and at the cellular level ( 15-17 ).…”

Section: Introductionmentioning

confidence: 99%

Honokiol inhibits endoplasmic reticulum stress‑associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells

Chen

Zhan

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Honokiol inhibits endoplasmic reticulum stress‑associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells

Chen

Zhan

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

“…As a bacterial infectious disease, endometritis is known to primarily affect the life of women and modern agricultural production, which is detrimental to human health and economic development (Zhao et al, 2017). Lipopolysaccharide (LPS) obtained from the cell wall of Gram-negative bacteria has been previously shown to play an important role in the pathogenesis of endometritis (Li et al, 2019;Zhou et al, 2019). Thus, it is used to induce endometritis in mice.…”

Section: Discussionmentioning

confidence: 99%

Combined Intestinal Metabolomics and Microbiota Analysis for Acute Endometritis Induced by Lipopolysaccharide in Mice

Dong

Yuan

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Endometritis is generally caused by bacterial infections, including both acute and chronic infections. In the past few decades, accumulated evidence showed that the occurrence of diseases might be related to gut microbiota. The progression of diseases is previously known to change the composition and diversity of intestinal microbiota. Additionally, it also causes corresponding changes in metabolites, primarily by affecting the physiological processes of microbiota. However, the effects of acute endometritis on intestinal microbiota and its metabolism remain unknown. Thus, the present study aimed to assess the effects of acute endometritis on intestinal microbes and their metabolites. Briefly, endometritis was induced in 30 specific pathogen-free (SPF) BALB/c female mice via intrauterine administration of lipopolysaccharide (LPS) after anesthesia. Following this, 16S rRNA gene sequencing and liquid chromatogram-mass spectrometry (LC-MS) were performed. At the genus level, the relative abundance of Klebsiella, Lachnoclostridium_5, and Citrobacter was found to be greater in the LPS group than in the control group. Importantly, the control group exhibited a higher ratio of Christensenellaceae_R−7_group and Parasutterella. Furthermore, intestinal metabolomics analysis in mice showed that acute endometritis altered the concentration of intestinal metabolites and affected biological oxidation, energy metabolism, and biosynthesis of primary bile acids. The correlation analysis between microbial diversity and metabolome provided a basis for a comprehensive understanding of the composition and function of the microbial community. Altogether, the findings of this study would be helpful in the prevention and treatment of acute endometritis in the future.

show abstract

“…Polydatin can inhibit inflammation induced by hyperosmolar stress reducing translocation of NF-kappaB to the nucleus and mRNA expression of TNF-alpha, IL-6, IL-1 beta, and MMP-9 (Park et al, 2019). Other studies concerning mice showed the ability of polydatin to reduce IL-6 production (Gu, Liu, Xu, & Lu, 2019;Kamel, Gad, Mansour, Safar, & Fawzy, 2018;Li et al, 2019).…”

Section: Natur Al Produc Ts and Covid -19mentioning

confidence: 99%

New intriguing possibility for prevention of coronavirus pneumonitis: Natural purified polyphenols

2020

View full text Add to dashboard Cite

Protective effects of polydatin on LPS-induced endometritis in mice

Cited by 16 publications

References 20 publications

Honokiol inhibits endoplasmic reticulum stress‑associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells

Honokiol inhibits endoplasmic reticulum stress‑associated lipopolysaccharide-induced inflammation and apoptosis in bovine endometrial epithelial cells

Combined Intestinal Metabolomics and Microbiota Analysis for Acute Endometritis Induced by Lipopolysaccharide in Mice

New intriguing possibility for prevention of coronavirus pneumonitis: Natural purified polyphenols

Contact Info

Product

Resources

About