Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells

Pereira, Olívia R.; Macı́as, Rocı́o I.R.; Pérez, Marı́a José; Marin, José J.G.; Cardoso, Susana M.

doi:10.1016/j.jff.2013.03.014

Cited by 36 publications

(34 citation statements)

References 31 publications

(33 reference statements)

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“…Herbal infusions are frequently used in traditional medicine due to their beneficial activities and among their constituents, special relevance has been given to phenolic compounds, which often exhibit high antioxidant capacity being able to counteract oxidative stress (Mejía, Songa, Hecka, Vinicio, & Ramírez-Mares, 2010;Pereira, Marcias, Perez, Marin & Cardoso, 2013). They act as antioxidants through various mechanisms, including hydrogen donating reactions, metal chelation, and up-regulation or protection of antioxidant defenses (e.g.…”

Section: Chemical Composition In Hydrophilic Compoundsmentioning

confidence: 99%

Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.

Barros

Pereira

Calhelha

et al. 2013

Journal of Functional Foods

288

383

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The bioactive properties (antioxidant and antitumour activities, and hepatotoxicity) of the infusion and methanolic extracts of Chenopodium ambrosioides L., a plant commonly used in Portuguese folk medicine, were compared. The chemical composition in hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) fractions were determined. In general, the infusion revealed higher antioxidant activity, while the methanolic extract was the only one showing antitumour effects against colon, cervical and hepatocellular carcinoma cell lines. No toxicity in non-tumour cells was observed either for the infusion or the extract. The studied plant proved to be a good source of natural antioxidants and other bioactive compounds, which may have industrial use. As far as we know, this is the first detailed chemical characterization and bioactivity evaluation of C. ambrosioides methanolic extract and infusion.

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Section: Chemical Composition In Hydrophilic Compoundsmentioning

confidence: 99%

Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.

Barros

Pereira

Calhelha

et al. 2013

Journal of Functional Foods

288

383

View full text Add to dashboard Cite

show abstract

“…The flavonoids were the most abundant phenolic compounds (quercetin 46.98% and kaempferol 45.91%), followed by phenolic acids (6.58%). The phenolic compounds are known by their high antioxidant activity [11,12]. Their role as antioxidants could follow several mechanisms, including hydrogen donation reactions, metal chelation and overregulation, or protection of antioxidant defense (levels of intracellular glutathione).…”

Section: Introductionmentioning

confidence: 99%

Study of the Performance of the Organic Extracts ofChenopodium ambrosioidesfor Ag Nanoparticle Synthesis

Carrillo-López

Soto-Hernández

Zavaleta‐Mancera

2016

Journal of Nanomaterials

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There are many ways to obtain metal nanoparticles: biological, physical, and chemical ways and combinations of these approaches. Synthesis assisted with plant extracts has been widely documented. However, one issue that is under discussion refers to the metabolites responsible for reduction and stabilization that confine nanoparticle growth and prevent coalescence between nanoparticles in order to avoid agglomeration/precipitation. In this study, Ag nanoparticles were synthesized using organic extracts ofChenopodium ambrosioideswith different polarities (hexane, dichloromethane, and methanol). Each extract was phytochemically characterized to identify the nature of the metabolites responsible for nanoparticle formation. With methanol extract, the compounds responsible for reducing and stabilizing silver nanoparticle were associated with the presence of phenolic compounds (flavonoids and tannins), while, with dichloromethane and hexane extracts, the responsible compounds were mainly terpenoids. Large part of the reducing activity of secondary metabolites inC. ambrosioidesis closely related to compounds with antioxidant capacity, such as phenolic compounds (flavone glycoside and isorhamnetin), which are the main constituents of the methanol extracts. Otherwise, terpenoids (trans-diol,α-terpineol, monoterpene hydroperoxides, and apiole) are the central metabolites present in dichloromethane and hexane extracts.

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“…In the present study, phytochemical analysis of this plant extract has determined polyphenols and flavonoids (20). The hypoglycemic effect of L. album could be in part attributed to its polyphenol compounds (37). Our study had some limitations: 1) we didn't measure plasma catecholamines and cortisol, since these hormones could affect neutrophil distribution (38,39).…”

Section: Discussionmentioning

confidence: 97%

Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats

et al. 2017

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Background: Diabetes mellitus (DM) is characterized by the presence of hyperglycemia. It has been documented that oxidative stress and reactive oxygen species (ROS) production have a key role in the pathogenesis of diabetes and its complications. Neutrophils as a part of immune system produce ROS, neutrophils function might be altered in diabetes. Lamium album is known to have antioxidant, and free radical scavenging actions. The aim of the present study was to evaluate the potential effect of L. album on mitochondrial ROS production from circulating neutrophils in diabetic rats. Materials and Methods: Twenty-one male Wistar rats were randomly divided into three groups: normal control rats receiving daily saline; diabetic control rats receiving daily saline; and diabetic rats treated daily with hydroalcoholic extract of L. album (100 mg/kg) for 28 days. On the 28 th day of treatment, whole blood samples were obtained and mitochondrial ROS of neutrophils were measured by dihydrorhodamine (DHR) flow cytometric method. Also, fasting blood sugar (FBS) was measured. Results: Mitochondrial ROS didn't show any significant differences among diabetic rats treated with L. album extract, diabetic control rats, and normal control rats (P=0.8). Serum glucose in diabetic control was significantly higher than normal control rats (P=0.0001). However, L. album caused a remarkable decrease in serum glucose of diabetic rats (P=0.03). Conclusion: According to the present findings, it seems that L. album at a dose of 100 mg/kg could not decrease mitochondrial ROS production from neutrophils in diabetic rats. Further studies considering higher concentrations of L. album are appreciated to evaluate its impact on the production of mitochondrial ROS along with extracellular ROS in diabetes condition.

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Protective effects of phenolic constituents from Cytisus multiflorus, Lamium album L. and Thymus citriodorus on liver cells

Abstract: Lamium album L. Thymus citriodorus Phenolic compounds

Cited by 36 publications

References 31 publications

Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.

Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L.

Study of the Performance of the Organic Extracts ofChenopodium ambrosioidesfor Ag Nanoparticle Synthesis

Effect of Lamium Album on Mitochondrial Oxidative Stress in Diabetic Rats

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