Protective effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
Changli Zhang,
Martha Elena Diaz-Hernandez,
Takanori Fukunaga
et al.
Abstract:Cellular senescence, characterized by a permanent state of cell cycle arrest and a secretory phenotype contributing to inflammation and tissue deterioration, has emerged as a target for age-related interventions. Accumulation of senescent cells is closely linked with intervertebral disc (IVD) degeneration, a prevalent age-dependent chronic disorder causing low back pain. Previous studies have highlighted that platelet-derived growth factor (PDGF) mitigated IVD degeneration through anti-apoptosis, anti-inflamma… Show more
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