Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota

Xiao, Mochao; Fu, Xiaopeng; Ni, Yali; Chen, Jifeng; Jian, Shaoqing; Wang, Liankai; Li, Li; Du, Guankui

doi:10.1016/j.jep.2018.08.012

Cited by 34 publications

(29 citation statements)

References 41 publications

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“…36,37 Xiao et al showed that Paederia scandens extracts could improve arthritis through reducing Mucispirillum. 38 The beneficial effects of dietary fiber, inulin and probiotic supplementation on metabolism and inflammation in diet-induced obese mice or db/db mice have also been reported to be associated with the decrease of Mucispirillum. [39][40][41] Our study also showed that significantly increased Mucispirillum induced by the high-fat diet was positively correlated with the maternal FBG levels.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

et al. 2019

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“…In recent years, a relationship between the therapeutic effect of Chinese herbal medicine and gut microbiome has been proved by researchers. Xiao M et al found that the diversity of gut microbiome increased in collageninduced arthritis mice treated with Paederia scandens (Chinese herbal medicine) (Xiao et al, 2018). In addition, the therapeutic effect of another Chinese herbal medicine, Tripterygium wilfordii (Chinese herbal medicine), used to treat RA has also been shown to be related to gut microbiome (Miao et al, 2015).…”

Section: Rheumatoid Arthritis Treatment Based On Gut Microbiomementioning

confidence: 99%

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

Yao¹,

Cai²,

Fei³

et al. 2020

Front. Pharmacol.

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone destruction. Microbial infection is considered to be the most important inducement of RA. The pregnancy planning of women in childbearing age is seriously affected by the disease activity of RA. Gut microbiome, related to immunity and inflammatory response of the host. At present, emerging evidence suggested there are significant differences in the diversity and abundance of gut microbiome during pregnancy and lactation, which may be associated with the fluctuation of RA disease activity. Based on these research foundations, we pioneer the idea of regulating gut microbiome for the treatment of RA during pregnancy and lactation. In this review, we mainly introduce the potential treatment strategies for controlling the disease activity of RA based on gut microbiome during pregnancy and lactation. Besides, we also briefly generalize the effects of conventional anti-rheumatic drugs on gut microbiome, the effects of metabolic changes during pregnancy on gut microbiome, alteration of gut microbiome during pregnancy and lactation, and the effects of anti-rheumatic drugs commonly used during pregnancy and lactation on gut microbiome. These will provide a clear knowledge framework for researchers in immune-related diseases during pregnancy. Regulating gut microbiome may be a potential and effective treatment to control the disease activity of RA during pregnancy and lactation.

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“…74 Long-term intake of ginseng extracts facilitates the growth of probiotics in the gut microbiota of rats and inhibits the colonization of some pathogenic bacteria including Helicobacter. 77 Ovotransferrin was also shown to ameliorate gut microbiota disorders in a mouse model where mice were injected with cyclophosphamide, resulting in a reduction of the relative abundance of Helicobacter and Desulfovibrio. 76 Paederia scandens extract, traditionally used to treat rheumatic pain, was shown to help restore the altered gut microbiota in a rheumatoid arthritis mouse model, resulting in a decreased relative abundance of inflammatory-related microorganisms including Helicobacter.…”

Section: G Row Th and Survival Of Non -Helicobac Ter Pylori Heli Comentioning

confidence: 99%

“…76 Paederia scandens extract, traditionally used to treat rheumatic pain, was shown to help restore the altered gut microbiota in a rheumatoid arthritis mouse model, resulting in a decreased relative abundance of inflammatory-related microorganisms including Helicobacter. 77 Ovotransferrin was also shown to ameliorate gut microbiota disorders in a mouse model where mice were injected with cyclophosphamide, resulting in a reduction of the relative abundance of Helicobacter and Desulfovibrio. 78 Egg phosvitin also reduced the number of Helicobacters in mouse models.…”

Section: G Row Th and Survival Of Non -Helicobac Ter Pylori Heli Comentioning

confidence: 99%

Review: Other Helicobacter species

Ménard

Smet

2019

Helicobacter

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This article is a review of the most important, accessible, and relevant literature published between April 2018 and April 2019 in the field of Helicobacter species other than Helicobacter pylori. The initial part of the review covers new insights regarding the presence of gastric and enterohepatic non‐H. pylori Helicobacter species (NHPH) in humans and animals, while the subsequent section focuses on the progress in our understanding of the pathogenicity and evolution of these species. Over the last year, relatively few cases of gastric NHPH infections in humans were published, with most NHPH infections being attributed to enterohepatic Helicobacters. A novel species, designated “Helicobacter caesarodunensis,” was isolated from the blood of a febrile patient and numerous cases of human Helicobacter cinaedi infections underlined this species as a true emerging pathogen. With regard to NHPH in animals, canine/feline gastric NHPH cause little or no harm in their natural host; however they can become opportunistic when translocated to the hepatobiliary tract. The role of enterohepatic Helicobacter species in colorectal tumors in pets has also been highlighted. Several studies in rodent models have further elucidated the mechanisms underlying the development of NHPH‐related disease, and the extra‐gastric effects of a Helicobacter suis infection on brain homeostasis was also studied. Comparative genomics facilitated a breakthrough in the evolutionary history of Helicobacter in general and NHPH in particular. Investigation of the genome of Helicobacter apodemus revealed particular traits with regard to its virulence factors. A range of compounds including mulberries, dietary fiber, ginseng, and avian eggs which target the gut microbiota have also been shown to affect Helicobacter growth, with a potential therapeutic utilization and increase in survival.

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Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota

Cited by 34 publications

References 41 publications

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

Review: Other Helicobacter species

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