Protective effects of oleanolic acid on cerebral ischemic damagein vivoand H2O2-induced injuryin vitro

Rong, Zhi-Tao; Gong, Xiaoyi; Sun, Hongbin; Li, Yunman; Ji, Hui

doi:10.3109/13880209.2010.499130

Cited by 43 publications

(45 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism is possibly attributed to activating Nrf2/HO-1 pathway. More recently, triterpenoids structurally similar to KBA, such as maslinic acid and oleanolic acid, have been reported to significantly increase Nrf2, leading to neuroprotection [20,11]. In another approach, stimulating Nrf2 by triterpenoid could effectively reduce 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress in the mouse model while Nrf2 knockout mice failed to block against MPTP neurotoxicity, implying a direct protective role of Nrf2/ARE against MPTP neurotoxicity [21].…”

Section: Discussionmentioning

confidence: 99%

“…The neuroprotective property of pentacyclic triterpenoid has drawn increasing interest during the past couple of years. By way of example, oleanolic acid shows protective effects on cerebral ischemic damage and H 2 O 2 -induced injury in vitro [11]. Similarly, ursolic acid, a naturally occurring pentacyclic triterpenoid, was reported to promote the neuroprotection after cerebral ischemia in mice by activating Nrf2 pathway [12].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

et al. 2014

View full text Add to dashboard Cite

Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. The nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway has been considered a potential target for neuroprotection in stroke. 11-Keto-β-boswellic acid (KBA) is a triterpenoid compound from extracts of Boswellia serrata. The aim of the present study was to determine whether KBA, a novel Nrf2 activator, can protect against cerebral ischemic injury. Middle cerebral artery occlusion (MCAO) was operated on male Sprague-Dawley rats. KBA (25 mg/kg) applied 1 h after reperfusion significantly reduced infarct volumes and apoptotic cells as well as increased neurologic scores at 48 h after reperfusion. Meanwhile, posttreatment with KBA significantly decreased malondialdehyde (MDA) levels, restored the superoxide dismutase (SOD) activity, and increased the protein Nrf2 and HO-1 expression in brain tissues. In primary cultured astrocytes, KBA increased the Nrf2 and HO-1 expression, which provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. But knockdown of Nrf2 or HO-1 attenuated the protective effect of KBA. In conclusion, these findings provide evidence that the neuroprotection of KBA against oxidative stress-induced ischemic injury involves the Nrf2/HO-1 pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The intraperitoneal administration of safranal (11) improved all these previous oxidative stress markers. Moreover, the triterpene oleanolic acid (105) acting as antioxidant attenuated the increased level of oxidative stress and the decline of mitochondrial function observed in hydrogen peroxide-treated PC12 cells and that produced as a consequence of cerebral ischemic in rats [54].…”

Section: Neuroprotectionmentioning

confidence: 99%

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

González-Burgos

Gómez-Serranillos

2012

CMC

289

157

View full text Add to dashboard Cite

Reactive Oxygen Species are involved in the pathological development of many important human diseases such as neurodegenerative diseases, cardiovascular processes, diabetes and many others. The most promising strategy to prevent from the oxidative damage caused by these reactive species is the use of antioxidant molecules. These compounds can act as direct antioxidants through free radical scavenging mechanisms and/or as indirect antioxidants by enhancing the antioxidant status (enzymatic and non-enzymatic). Terpenes, one of the most extensive and varied structural compounds occurring in nature, display a wide range of biological and pharmacological activities. Here we highlight their antioxidant properties. Due to their antioxidant behaviour terpenes have been shown to provide relevant protection under oxidative stress conditions in different diseases including liver, renal, neurodegenerative and cardiovascular diseases, cancer, diabetes as well as in ageing processes. Evidence for this comes from the increasing number of publications on this issue in recent years. This review provides a complete overview of the natural terpenes with potential antioxidant properties, focusing on their source, structures, antioxidant mechanisms through which they exert their pharmacological and possible therapeutic activities.

show abstract

“…Cells protect themselves from oxidative damage through free radical scavenging systems such as enzymatic [catalase, superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px)] and nonenzymatic (flavonoids, vitamin C, and vitamin E) (Sies & Murphy, 1991;Mostafa et al, 2006). Countless studies have shown antioxidant therapies could be effective in preventing ischemia/reperfusion injury Khan et al, 2007;Rong et al, 2011). Therefore, administration of antioxidants could give potential benefit by enhancing the activities of antioxidant enzymes or scavenging free radicals and was used as a protection strategy to alleviate ischemia/reperfusion…”

Section: Introductionmentioning

confidence: 99%

The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes

Meng

Hou

Yang

et al. 2012

Pharmaceutical Biology

View full text Add to dashboard Cite

Protective effects of oleanolic acid on cerebral ischemic damagein vivoand H₂O₂-induced injuryin vitro

Cited by 43 publications

References 26 publications

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia–Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

Terpene Compounds in Nature: A Review of Their Potential Antioxidant Activity

The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes

Contact Info

Product

Resources

About