Protective Effects of Nigella Sativa on Intestinal Ischemia-Reperfusion Injury in Rats

Abstract

Our results suggest that NS treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury.

<b><i>Nigella Sativa</i></b> Reduces Tissue Damage in Rat Ovaries Subjected to Torsion and Detorsion: Oxidative Stress, Proinflammatory Response and Histopathological Evaluation

“…Its scavenging actions have been demonstrated in a number of tissues [40,41,42,58], although the protection for ovaries has not been evaluated in detail. In the present study, a reduction in SOD and GSH levels and an increase in MDA levels occurred after a period of ischemia followed by reperfusion.…”

“…Recently, clinical and animal studies have shown that an extract of NS has many therapeutic effects, including antiproliferative, anti-inflammatory, antitumor, anticancer, multiple myeloma, antibacterial, estrogenic, and antioxidant activity [32,33,34,35,36,37,38,39]. Experimental studies have also revealed that thymoquinone has protective effects against I/R injury in the intestine [40], liver [41], kidney [42], and testicular torsion [43]. It has also been reported that the crude NS seeds did not produce any adverse side effects at the doses tested [44].…”

Protective Effects of Black Cumin (Nigella sativa) Oil on TNBS-Induced Experimental Colitis in Rats

“…Black cumin oil (BCO) contains more than 30% fixed oil and 0.4-0.45% volatile oil. In volatile oil analysis, many components have been characterized, but the major ones are thymoquinone (27.8-57.0%), q-cymene (7.1-15.5%), carvacrol (5.8-11.6%), t-anethole (0.25-2.3%), 4-terpineol (2.0-6.6%), and longifoline (1.0-8.0%) [18,19]. Nigella sativa oil is so beneficial due to its content of over 100 components such as aromatic oils, trace elements, vitamins, and enzymes.…”

Examination of Oxidative Stress Parameters in Experimental Mesenteric Ischemia Model

“…There is no correlation between any of the biochemical parameters and histopathological damage score. In an experimental ischemia reperfusion study involving rats, Terzi A et al observed that OSI and TOS increased in ileum tissue in rats exposed to ischemia reperfusion, while TAS decreased (22 …”