Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: Role of NO, HO-1, and COX-1,2

Morsy, Mohamed A.; Heeba, Gehan H.; Abdelwahab, Sayed F.; Rofaeil, Remon Roshdy

doi:10.1016/j.niox.2012.06.001

Cited by 34 publications

(33 citation statements)

References 34 publications

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“…This result supported the previous studies done on stressinduced gastric ulcers by Morsy et al and Seo et al where ulcers were ameliorated by the use of losartan and enalapril to shallow erosions and congestion, also this result was in harmony with similar studies done by Nakagiri et al 12 and Fouad et al who evaluated the effects of pre-treatment of losartan, candesartan and valsartan on ischemia/reperfusion-induced gastric ulcer and the effect of telmisartan on indomethacin-induced gastric ulceration in rats respectively, where the ulcers were ameliorated to superficial gastric mucosal lesions. [25][26][27] Moreover, the present study revealed that there is a significant increase in mucosal PGE2, SOD, and NO levels, compared to ulcer group with no significant difference between losartan and enalapril.…”

Section: Discussionsupporting

confidence: 50%

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Ahmed

Abdelrahim

Abdel-Latif

2016

Int J Basic Clin Pharmacol

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Section: Discussionsupporting

confidence: 50%

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Ahmed

Abdelrahim

Abdel-Latif

2016

Int J Basic Clin Pharmacol

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“…Rats were starved for 24 h prior to the experiment in mesh-bottomed cages to minimize coprophagia but allowed free access to water except for the last hour before the experiment [12]. Pyloric ligation was performed under ether anesthesia to enable collection of gastric juice at the end of the experiment.…”

Section: Methodsmentioning

confidence: 99%

Mechanisms of the Protective Effects of Curcumin against Indomethacin-Induced Gastric Ulcer in Rats

Morsy

El‐Moselhy

2013

Pharmacology

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Background/Aims: Curcumin, a naturally occurring polyphenolic compound, exhibits anti-inflammatory and antioxidant properties that render it an attractive candidate for protection against gastric ulcer. The aim of this study is therefore to evaluate the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. Methods: Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg). Curcumin (50 mg/kg, p.o.) was administered 30 min before ulcer induction. Results: Curcumin showed gastroprotective effects as evidenced by significant decreases in ulcer index, total acid output and pepsin activity in gastric juice in addition to gastric mucosal malondialdehyde concentration, and concomitant increases in gastric juice mucin concentration, gastric mucosal nitric oxide level and catalase and superoxide dismutase activities as compared to the indomethacin-induced ulcer group. Moreover, immunohistochemical investigations demonstrated that curcumin treatment markedly decreased expression of inducible nitric oxide synthase, nuclear factor-κB, and caspase-3. Conclusion: Curcumin protected the rats' gastric mucosa against indomethacin-induced gastric ulceration possibly, at least in part, by enhancement of the gastric mucosal barrier and reduction in acid secretory parameters in addition to antioxidant and antiapoptotic activities.

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“…Una úlcera iende como una lesión de carácter crónico y recurrente que se caracteriza por la pérdida de integridad y presencia de un proceso inflamatorio en la mucosa gástrica o intestinal [4,5,6]. La fisiopatología de las úlceras gástricas se atribuye al desbalance corrosivos y los mecanismos de gastroprotección de la mucosa gástrica, los cuales incluyen una adecuada motilidad gastrointestinal y perfusión gástrica, una barrera de moco continua e intacta y mediadores bioquímicos como las prostaglan y el óxido nítrico [7,8].…”

Section: Licania Platypusunclassified

Efecto del extracto acuoso de hojas de <i>Licania platypus (Hemsl.) Fritsh</i>. Sobre la protección gástrica y la motilidad gastrointestinal.

Aguilar¹,

Rojas²,

Flores³

et al. 2018

Rev Med UCR

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Licania platypus se distribuye ampliamente en países tropicales. Tradicionalmente, en América Central se ha utilizado para diversos problemas de salud, especialmente gastrointestinales. Objetivo: Investigar la actividad antiulcerosa gástrica y el efecto sobre la motilidad gastrointestinal del extracto acuoso de hojas de Licania platypus. Métodos: El daño gástrico fue inducido con los modelos de etanol e indometacina y se evaluaron otros parámetros en el modelo de ligadura pilórica. Además, se analizó el efecto sobre la motilidad gastrointestinal utilizando rojo de fenol. Resultados: La administración oral del extracto acuosos (1000mg/kg) redujo significativamente el área de las lesiones gástricas (p<0,05) en ambos modelos. Se observó un incremento en el volumen de las secreciones gástricas y en la secreción de moco gástrico, además de una disminución en la acidez total y en la peroxidación lipídica (p<0,05). El extracto acuoso de Licania platypus brinda un efecto gastroprotector en diferentes modelos de inducción de úlceras agudas y una disminución en el vaciamiento gástrico. Las actividades demostradas en este estudio contribuyen con el conocimiento etnofarmacológico atribuido a Licania platypus.

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Protective effects of nebivolol against cold restraint stress-induced gastric ulcer in rats: Role of NO, HO-1, and COX-1,2

Cited by 34 publications

References 34 publications

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

Mechanisms of the Protective Effects of Curcumin against Indomethacin-Induced Gastric Ulcer in Rats

Efecto del extracto acuoso de hojas de <i>Licania platypus (Hemsl.) Fritsh</i>. Sobre la protección gástrica y la motilidad gastrointestinal.

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