Protective Effects of Metformin Against Biochemical Failure Following Radical Prostatectomy or Radiation Therapy in Localized Prostate Cancer

Huynh, Linda; Keit, Emily; Huang, Erica; Carrillo, Raymond Ceja; Ahlering, Thomas E.; Boyle, Shawna; Enke, Charles Arthur; Baine, Michael J.

doi:10.1016/j.urology.2021.01.030

Cited by 1 publication

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“…Previous epidemiological studies have suggested that there may be an inverse association between metformin use and prostate cancer biochemical recurrence. Some studies have been suggestive of an inverse association without reaching statistical significance, 8–11 while others have observed as statistically significant inverse association 12–14 . A 2015 meta‐analysis suggested a non‐statistically significant inverse association between metformin use and biochemical recurrence 15 .…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have been suggestive of an inverse association without reaching statistical significance, [8][9][10][11] while others have observed as statistically significant inverse association. [12][13][14] A 2015 meta-analysis suggested a non-statistically significant inverse association between metformin use and biochemical recurrence. 15 Similarly, several studies have suggested that statins may also be protective against biochemical recurrence, although results are not consistent.…”

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confidence: 99%

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Post‐diagnostic metformin and statin use and risk of biochemical recurrence in Veterans diagnosed with prostate cancer

et al. 2023

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Objective To evaluate the impact of post‐diagnostic metformin or statin use and duration on risk of biochemical recurrence in a racially‐diverse cohort of Veterans. Methods The population consisted of men diagnosed with prostate cancer in the Veterans Health Administration and treated with either radical prostatectomy or radiation (Full cohort n = 65,759, Black men n = 18,817, White men n = 46,631, Other = 311). The association between post‐diagnostic (1) metformin and (2) statin use with biochemical recurrence was assessed using multivariable, time‐varying Cox Proportional Hazard Models for the overall cohort and by race. In a secondary analysis, metformin and statin duration were evaluated. Results Post‐diagnostic metformin use was not associated with biochemical recurrence (multivariable‐adjusted hazard ratio [aHR]: 1.01; 95% confidence interval [CI]: 0.94, 1.09), with similar results observed for both Black and White men. However, duration of metformin use was associated with a reduced risk of biochemical recurrence in the cohort overall (HR: 0.94; 95% CI: 0.92, 0.95) as well as both Black and White men. By contrast, statin use was associated with a reduced risk of biochemical recurrence (HR: 0.83; 95% CI: 0.79, 0.88) in the overall cohort as well as both White and Black men. Duration of statin use was also inversely associated with biochemical recurrence in all groups. Conclusion Post‐diagnostic metformin and statin use have the potential to prevent biochemical recurrence in men diagnosed with prostate cancer.

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Section: Introductionmentioning

confidence: 99%