Protective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in rats

Sarıhan, Mehmet Ediz; Parlakpınar, Hakan; Çiftçi, Osman; Yilmaz, Fethi; Sağır, Mustafa; Yilmaz, Ömür; Ceker, Gokhan

doi:10.1016/j.ejphar.2015.04.054

Cited by 9 publications

(9 citation statements)

References 35 publications

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“…In contrast to the TCDD group, the TCDD+TAU group had significantly lower TBARS levels, while GSH and SOD levels were higher. Similar to our results, it has been reported that TCDD significantly increased lipid peroxidation and decreased antioxidant activities, and that melatonin treatment significantly protected subjects from TCDD-induced cardiotoxicity in rats [34]. It has been shown that taurine treatment protected against oxidative damage in erythrocytes of tertiary butyl hydroperoxide-exposed mice by increasing GSH levels and decreasing MDA and ROS levels [35].…”

Section: Immunohistochemical Evaluationssupporting

confidence: 91%

Taurine Prevents Against 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Oxidative Stress in the Liver and Kidney of Rats

Doğan

ÇİFTÇİ

Türkmen

et al. 2023

Ankara Ecz. Fak. Derg.

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Objective: The aim of the study was to investigate the preventive effects of Taurine against 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD)-induced organ damage in rats. The environmental toxin TCDD has a high toxicity in animal and human tissues. Taurine is an amino acid found in organ cells that has and antioxidant properties and anti-inflammatory. As a result, the potential preventive effect of taurine on oxidative stress and organ damage caused by TCDD was investigated in rat liver and kidney tissues by measuring glutathione (GSH), superoxide dismutase (SOD) activity, and thiobarbituric acid reactive substances (TBARS) levels. Material and Method: Adult male Wistar rats (250-300 g, 12-13 weeks, n = 32) were randomly allocted into four groups (n = 8/group): Control, TCDD, TAU, and TCDD+TAU. TCDD and/or taurine were administered via gavage in doses of 2 μg/kg/week and 200 mg/kg/day, respectively. Result and Discussion: The results showed that TCDD caused oxidative stress in the liver and kidney tissues of rats by decreasing the levels of GSH and SOD activity and increasing the levels of TBARS. Taurine treatment significantly reduced TBARS levels (p

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Section: Immunohistochemical Evaluationssupporting

confidence: 91%

Taurine Prevents Against 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Oxidative Stress in the Liver and Kidney of Rats

Doğan

ÇİFTÇİ

Türkmen

et al. 2023

Ankara Ecz. Fak. Derg.

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“…Melatonin prevented the DXR-induced elevated MDA levels. There are studies in the literature that have reported melatonin to decrease MDA levels (26,27,28,33). In the present study, the fact that TQ was not able to generate a signifi cant difference in MDA levels despite causing a decrease towards control levels can be explained by the large standard deviation values.…”

Section: Evaluation Of Biochemical Fi Ndingsmentioning

confidence: 52%

“…The histopathological changes induced by DXR were signifi cantly improved by melatonin, whereas the improvement caused by TQ was not pronounced enough to reach statistical signifi cance. In the literature, melatonin has been reported to reduce the cardiac injury induced by DXR (32) (33) and 2,3,7,8-Tetrachlorodibenzo--p-dioxin (27).…”

Section: Evaluation Of Histological Fi Ndingsmentioning

confidence: 99%

The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats

PEHLİVAN>¹,

Durdağı²,

Oyar³

et al. 2020

BLL

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OBJECTIVES: This study aims to investigate the protective effects of thymoquinone and melatonin on the heart against doxorubicin-induced cardiotoxicity in rats. BACKGROUND: Melatonin and thymoquinone may play an important role in cardiotoxicity. METHODS: The subjects were divided into four groups: Control (physiological serum on 5th day), Doxorubicin (DXR), Doxorubicin+Melatonin (DXR+MEL, 10 mg/kg melatonin, intraperitoneally), and Doxorubicin+Thymoquinone (DXR+TQ, 50 mg/kg thymoquinone, orally). On the 5th day of the experiment, all groups were injected with 45 mg/kg DXR into the tail vein. On the 8th day of the experiment, ECG recordings were performed under anaesthesia. RESULTS: Thymoquinone reduced the PR, QRS and QTc intervals, which were increased by DXR, while melatonin only reduced the QTc interval. Melatonin had a protective effect against the histopathological changes induced by DXR, while TQ did not demonstrate such an effect. DXR increased CK-MB, IL-6, MDA, IL-1, IL-18 levels and decreased SOD in the cardiac tissue. MEL reduced the levels of CK-MB, MDA, NO, SOD, IL-1, IL-6, IL-18. Meanwhile, TQ only reduced CK-MB, IL-1 and IL-18. CONCLUSION: Our study showed that DXR induces cardiac injury and that melatonin improves biochemical parameters and offers histological protection; while thymoquinone improves ECG parameters and causes partial recovery of biochemical parameters (Tab. 4, Fig. 2, Ref. 41).

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“…Human exposure to TCDD has been associated with cardiovascular complication. 48,49 One mechanism by which TCDD causes cardiotoxicity is generation of ROS leading to an increase in TBARS levels and a decrease in SOD, GSH, and CAT in the heart. Melatonin ameliorates ROS generation by its antioxidant activity and also activates several antioxidative enzymes while decreasing lipid peroxidation.…”

Section: Dioxin: 2378 Tetrachlorodibenzo-p-dioxin (Tcdd)mentioning

confidence: 99%

“…Melatonin ameliorates ROS generation by its antioxidant activity and also activates several antioxidative enzymes while decreasing lipid peroxidation. 49…”

Section: Dioxin: 2378 Tetrachlorodibenzo-p-dioxin (Tcdd)mentioning

confidence: 99%

Melatonin attenuates chemical-induced cardiotoxicity

et al. 2020

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Environmental chemicals and drugs can induce cardiotoxicity, mainly by generating free radicals. Reactive oxygen species play a critical role in the pathogenesis of cardiac tissue injury. This highlights a need for prevention of cardiotoxicity by scavenging free radicals. Melatonin has been shown to act as a protector against various conditions in which free radicals cause molecular and tissue injury. Some of the mechanisms by which melatonin operates as a free radical scavenger and antioxidant have been identified. The importance of endogenous melatonin in cardiovascular health and the benefits of melatonin supplementation in different cardiac pathophysiological disorders have been shown in a variety of model systems. Melatonin continues to attract attention for its potential therapeutic value for cardiovascular toxicity. The therapeutic potential of melatonin in treatment of cardiotoxicities caused by various chemicals along with suggested molecular mechanisms of action for melatonin is reviewed.

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Protective effects of melatonin against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cardiac injury in rats

Cited by 9 publications

References 35 publications

Taurine Prevents Against 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Oxidative Stress in the Liver and Kidney of Rats

Taurine Prevents Against 2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Oxidative Stress in the Liver and Kidney of Rats

The effects of melatonin and thymoquinone on doxorubicin-induced cardiotoxicity in rats

Melatonin attenuates chemical-induced cardiotoxicity

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