Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure: Role of inflammation and TLR4

Atabaki, Rabi; Roohbakhsh, Ali; Moghimi, Ali; Mehri, Soghra

doi:10.1016/j.intimp.2020.106720

Cited by 19 publications

(12 citation statements)

References 134 publications

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“…This is in line with a previous report that found human mesenchymal stem cells treated with 5 μM hesperidin reduced the expression of il-10 , along with other proinflammatory cytokines ( Xiao et al, 2018 ). In another study, hesperidin decreased il-10 expression and reversed memory impairment in rat pups with hyperthermia-induced febrile seizures ( Atabaki et al, 2020 ). Antiepileptic drug treatment is well considered to be associated with the modulation of cytokines.…”

Section: Discussionmentioning

confidence: 96%

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

et al. 2021

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Hesperidin (3,5,7-trihydroxyflavanone 7-rhamnoglucoside) is a β-7-rutinoside of hesperetin (4′-methoxy-3′,5,7-trihydroxyflavanone), abundantly found in citrus fruits and known to interact with various cellular pathways to show a variety of pharmacological effects. The present study was envisaged to understand the anticonvulsant effect of hesperidin in a zebrafish model of pentylenetetrazole (PTZ)-induced convulsions, with the support of in silico docking. Healthy zebrafish larvae were preincubated with hesperidin (1, 5, and 10 µM) for 1 h, before PTZ exposure. Hesperidin treatment significantly increased the seizure latency and minimized PTZ-induced hyperactive responses. A significant reduction in c-fos expression further supported the suppression of neuronal excitation following hesperidin incubation in the larvae exposed to PTZ. The treatment also modulated larval bdnf expression and reduced the expression of il-10. The results of in vivo studies were further supported by in silico docking analysis, which showed the affinity of hesperidin for the N-methyl-d-aspartate receptor, the gamma-aminobutyric acid receptor, Interleukin 10 and the TrkB receptor of brain-derived neurotrophic factor. The results concluded that hesperidin suppresses PTZ-mediated seizure in zebrafish larvae through interaction with the central CREB–BDNF pathway.

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Section: Discussionmentioning

confidence: 96%

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

et al. 2021

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“…Before inducing LTP, stable baseline synaptic responses were recorded for 30 min, and then a high‐frequency stimulus (HFS; 100 pulses delivered at 100 Hz) was used to induce LTP. Synaptic responses were recorded 90 min following LTP induction (Anaeigoudari et al, 2016; Atabaki et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…Then the animal skull was exposed, and CA1 and Schaffer collateral coordinates were determined on the skull according to the atlas of Paxinos and Watson (2007). The recording electrode was lowered from the left side of the skull and positioned in the right CA1 stratum radiatum (coordinates; AP = −3.4 mm, ML = 1.5, DV = 4.4-5.1, at an angle of 52.5°) and a bipolar stimulating electrode was positioned in the ipsilateral Schaffer collateral pathway (coordinates; AP = −4.2 mm, ML = −3.8 mm, DV = 2.7-3.8 mm; Figure 2; Sadeghi et al, 2017 (Anaeigoudari et al, 2016;Atabaki et al, 2020).…”

Section: Experimental Designmentioning

confidence: 99%

Losartan improved hippocampal long‐term potentiation impairment induced by repeated LPS injection in rats

2021

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“…Consequently, any lifestyle-related intervention, including dietary interventions that increase hesperidin bioavailability [95] and help to maintain the health of the cardiovascular and respiratory systems, may make the person infected with SARS-CoV-2 less susceptible to its more severe complications. The risk of some chronic diseases like cerebrovascular disease and asthma is lower at higher dietary hesperetin intake [100], and a number of papers report beneficial effects in animal models of neurodegenerative disorders [96,101,102] and hyperthermia-induced febrile seizures [103]. Gene expression analysis has shown that hesperidin modulates the expression of genes involved in atherogenesis, inflammation, cell adhesion and cytoskeletal organization [104].…”

Section: Other Useful Effectsmentioning

confidence: 99%

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Bellavite

Donzelli²

2020

Antioxidants

159

140

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Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action or be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of citrus fruits, and especially of the orange (Citrus sinensis), well known for its vitamin and flavonoid content. Among the flavonoids, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy, both with the coronavirus “spike” protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The binding energy of hesperidin to these important components is lower than that of lopinavir, ritonavir, and indinavir, suggesting that it could perform an effective antiviral action. Furthermore, both hesperidin and ascorbic acid counteract the cell damaging effects of the oxygen free radicals triggered by virus infection and inflammation. There is discussion about the preventive efficacy of vitamin C, at the dose achievable by the diet, but recent reviews suggest that this substance can be useful in the case of strong immune system burden caused by viral disease. Computational methods and laboratory studies support the need to undertake apposite preclinical, epidemiological, and experimental studies on the potential benefits of citrus fruit components for the prevention of infectious diseases, including COVID-19.

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Protective effects of maternal administration of curcumin and hesperidin in the rat offspring following repeated febrile seizure: Role of inflammation and TLR4

Cited by 19 publications

References 134 publications

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

Hesperidin Interacts With CREB-BDNF Signaling Pathway to Suppress Pentylenetetrazole-Induced Convulsions in Zebrafish

Losartan improved hippocampal long‐term potentiation impairment induced by repeated LPS injection in rats

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

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