Protective Effects of Lazaroid U74389G on Intestinal Graft after Heterotopic Small Bowel Transplantation in Rats

de, Javier; S, Cuadrado; Vallet, J.; Benasco, C; Martín, Eduardo; Ardanuy, Carmen; Closa, Daniel; Hotter, Georgina; Jaurrieta, Eduardo

doi:10.1006/jsre.1997.5244

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…The research team compared the histologic profile between these groups and observed that in group 1 the epithelium was completely conserved with numerous mucous cells and in some zones of villi a minimal separation of the layer of epithelial cells from lamina propria was present. On the other hand, in group 2, the grade of injury was characterized by a diffuse architectural alteration due to the flattening of the vertex in the villi, where large subepithelial spaces were observed together with areas of massive prolapse of the epithelium and denudation of the vertex [6,28].…”

Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 98%

“…The inhibition of TNF-a serum levels might also contribute to the reduction of leukocytes [27]. Javier de Oca et al investigated the protective effects of lazaroid U-74389G on intestinal grafts after heterotopic small bowel transplantation [6]. The research team used three groups of male Lewis rats.…”

Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 98%

“…The release of all these agents may lead to distant pathophysiologic effects, including hepatic and pulmonary dysfunction, systemic and local hypotension, necrotizing enterocolitis, mesenteric insufficiency in the elderly, and intestinal dysfunction after bowel transplantation. The effect of these derangements and the inability of suitable therapeutic options result in significant mortality rates that are associated with these conditions [6,12].…”

Section: Intestinal (I/r) Injurymentioning

confidence: 99%

“…The researcher concluded that the percentage conversion of xanthine dehydrogenase/xanthine was significantly higher in the second transplant group. The sham group presented low MDA, reflecting absence of damage due to ischemia and reperfusion [6]. The effect of the transplant on lipid peroxidation (LPO) in the graft was made clear after comparing the MDA tissue levels of the sham group to the vehicle treated group.…”

Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 99%

“…This increase in microvascular permeability causes the activation and adhesion of polymorphonuclear neutrophils (PNMs), the release of proinflammatory substances, and the formation of nitrogen and oxygencentered free radicals (OFR). The injury caused by reperfusion is found predominantly in the intestinal mucosa and submucosa, causing endothelial detachment [6,7].…”

Section: Intestinal (I/r) Injurymentioning

confidence: 99%

See 4 more Smart Citations

Effects of Lazaroids on Intestinal Ischemia and Reperfusion Injury in Experimental Models

Flessas

Papalois

Toutouzas

et al. 2011

Journal of Surgical Research

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Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 98%

Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 98%

Section: Intestinal (I/r) Injurymentioning

confidence: 99%

Section: Role Of Experimental Models Of Intestinal I/r Injurymentioning

confidence: 99%

Section: Intestinal (I/r) Injurymentioning

confidence: 99%

See 3 more Smart Citations

Effects of Lazaroids on Intestinal Ischemia and Reperfusion Injury in Experimental Models

Flessas

Papalois

Toutouzas

et al. 2011

Journal of Surgical Research

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Baterial Translocation in Humans

Lichtman

2001

J. pediatr. gastroenterol. nutr.

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Bacterial translocation is a phenomenon in which live bacteria cross the intestinal barrier. The definition may be broadened to include transmural passage of bacterial cell wall components such as lipopolysaccharide and peptidoglycan polysaccharide. After translocation, bacteria or their products reach the mesenteric lymph nodes. From there, it is possible that enteric bacteria, their cell wall components, or both may disseminate throughout the body, causing sepsis, shock, multisystem organ dysfunction, or death of the host. Bacterial translocation and its complications have been shown clearly to occur in animal models, but its existence and importance in humans has been difficult to ascertain. The purpose of this review is to evaluate the data from studies in humans on the occurrence of bacterial translocation and, more importantly, to evaluate its role as a cause of death in humans. Studies from trauma and intensive care centers often imply that bacterial translocation is a major contributor to sepsis, shock, and multisystem organ failure in humans. However, the data reviewed herein do not support that view clearly. Carefully designed studies are needed to determine the relevance of bacterial translocation in human disease.

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The effects of the 21-aminosteroid U-74389G on spatial orientation in rats after a cerebral oligemic episode and iron-induced oxidative stress

Heim

Kolasiewicz

Sontag

2000

Journal of Neural Transmission

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Oligemic episodes and increased iron concentration have both been proposed as being involved in neurodegenerative diseases. In animal models, a combination of both of these might therefore mimic the clinical pathology in humans. In rats, intrastriatal injections of ferric chloride, FeCl3, one week after a 60-minute oligemic episode, produced by bilateral clamping of the carotid arteries under pentobarbital anaesthesia (BCCA) impaired the animals' learning ability in a water maze task. Median adult rats, after intrastriatal 0.3 microg FeCl3, are impaired when challenged during the first three trial blocks, while after 0.06 microg FeCl3, an impairment is seen during the process of habituation to the challenge. Two-year-old animals do not show any learning effect at all after the combination of BCCA and intrastriatal FeCl3. Lazaroid U-74389G, a potent inhibitor of iron-induced lipid peroxidation, totally prevents the learning impairments in both median adult and aged animals, suggesting that iron-induced lipid peroxidation may be responsible for the late learning deficiencies. However, when U-74389G is applied one week after the oligemic episode but without the additional injection of iron, U-74389G on its own also impairs the animals' learning ability. The present animal model, when applied to clinical studies of lazaroids in humans, does seem able to give reliable information concerning the neuroprotective properties of such drugs.

show abstract

Protective Effects of Lazaroid U74389G on Intestinal Graft after Heterotopic Small Bowel Transplantation in Rats

Cited by 17 publications

References 24 publications

Effects of Lazaroids on Intestinal Ischemia and Reperfusion Injury in Experimental Models

Effects of Lazaroids on Intestinal Ischemia and Reperfusion Injury in Experimental Models

Baterial Translocation in Humans

The effects of the 21-aminosteroid U-74389G on spatial orientation in rats after a cerebral oligemic episode and iron-induced oxidative stress

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