Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses

Tang, Chao; Meng, Fanqiang; Pang, Xinyi; Chen, Meirong; Zhou, Libang; Lu, Zhaoxin; Lu, Yingjian

doi:10.1016/j.jff.2020.104206

Cited by 14 publications

(26 citation statements)

References 60 publications

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“…Data are presented as mean ± SD. Different lowercase alphabet letters were significantly different at level of p < .05 reduced OA-induced ROS production and lipid peroxidation product MDA (Tang et al, 2020), which may alleviate mitochondrial dysfunction and stimulate mitochondrial biogenesis. MFN1, MFN2, and OPA1 are critical to regulate the fusion of mitochondria, whereas Fis1 and Drp1 are responsible for participating in mitochondrial fission (Bozi et al, 2020).…”

Section: Discussionmentioning

confidence: 94%

“…Given that fission contributes to increased number of mitochondria (Bozi et al, 2020), it is speculated that CFE-mediated increased mitochondrial number is due to stimulation of mitochondrial fission (Tang et al, 2020). Loss of mitochondrial membrane potential (MMP) could initiate PINK/Parkin pathway, one of mitophagyrelated pathways (Natarajan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Preparation of CFE from L. acidophilus NX2-6 was carried out according to our previous protocol (Tang et al, 2020).…”

Section: Preparation Of Cell-free Extractsmentioning

confidence: 99%

“…All genes involved in signaling pathways were detected using Rt-PCR analysis. The detailed procedures were described as our previously reported study (Tang et al, 2020). All primers were listed in Table S1.…”

Section: Quantitative Real-time Pcr Analysismentioning

confidence: 99%

“…Previous literature also discovered that some strains belonging to Lactobacillus acidophilus were beneficial to hepatic protection (Li et al, 2016). In our previous study, CFE was determined to reduce intracellular triglyceride content and reactive oxygen species (ROS) in oleic acid (OA)-treated HepG2 cells (Tang et al, 2020). In this study, we mainly explored the underlying mechanism.…”

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confidence: 98%

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Regulatory mechanisms of energy metabolism and inflammation in oleic acid‐treated HepG2 cells from Lactobacillus acidophilus NX2‐6 extract

et al. 2021

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Non-alcoholic fatty acid liver (NAFLD), a prevalent liver disease, is accompanied by abnormal lipid accumulation in the hepatocytes without excess ethanol consumption. It is estimated that about 20%-30% of adults suffer from excess hepatic fat accumulation (Neuschwander-Tetri & Caldwell, 2003). Meanwhile, NAFLD is positively correlated with the pathogenesis of obesity, type II diabetes (T2DM), cardiovascular diseases, and other metabolic disorders (Leung et al., 2016). Thus, the prevalence of NAFLD potentially affects host health. By now, several investigations have revealed that the pathogenesis of NAFLD is accompanied with the disorder

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

“…Preparation of CFE from L. acidophilus NX2-6 was carried out according to our previous protocol (Tang et al, 2020).…”

Section: Preparation Of Cell-free Extractsmentioning

confidence: 99%

Section: Quantitative Real-time Pcr Analysismentioning

confidence: 99%

mentioning

confidence: 98%

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Regulatory mechanisms of energy metabolism and inflammation in oleic acid‐treated HepG2 cells from Lactobacillus acidophilus NX2‐6 extract

et al. 2021

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Ameliorated effects of a lipopeptide surfactin on insulin resistance in vitro and in vivo

Chen

Zhao

Meng

et al. 2022

Food Science & Nutrition

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Surfactin, produced by Bacillus amyloliquefaciens fmb50, was used to treat insulin‐resistant (IR) hepatocyte. It was found that surfactin increased glucose consumption in insulin‐resistant HepG2 (IR‐HepG2) cells and ameliorated IR by increasing glucose transporter 4 (GLUT4) protein expression and AMP‐activated protein kinase (AMPK) mRNA expression, promoting GLUT4 translocation and activating phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) in IR‐HepG2 cells. Meanwhile, surfactin downregulated protein expression of phosphoenolpyruvate carboxy kinase (PEPCK) and glucose‐6‐phosphatase (G6Pase), further inhibiting hepatic gluconeogenesis. In addition, surfactin played important roles in eliminating reactive oxygen species (ROS), improving mitochondrial dysfunction, and inhibiting proinflammatory mediators. We observed that surfactin promoted glucose consumption, meanwhile increased translocation and protein expression of GLUT4 in Caco‐2 cells. These results confirmed the conclusion in hepatic cells. Furthermore, surfactin supplement decreased body weight, food intake, and fasting blood glucose of type 2 diabetes mellitus (T2DM) mice induced by streptozotocin (STZ)/high‐fat diet (HFD). Our data indicated that surfactin ameliorated insulin resistance and lowered blood glucose in intro and in vivo.

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Regulation of Hepatocellular Cholesterol Metabolism By Lactobacillus Paracasei BY2 and Its Embedding Delivery

Cui

Liu

et al. 2022

Probiotics & Antimicro. Prot.

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Protective effects of Lactobacillus acidophilus NX2-6 against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress and inflammatory responses

Cited by 14 publications

References 60 publications

Regulatory mechanisms of energy metabolism and inflammation in oleic acid‐treated HepG2 cells from Lactobacillus acidophilus NX2‐6 extract

Regulatory mechanisms of energy metabolism and inflammation in oleic acid‐treated HepG2 cells from Lactobacillus acidophilus NX2‐6 extract

Ameliorated effects of a lipopeptide surfactin on insulin resistance in vitro and in vivo

Regulation of Hepatocellular Cholesterol Metabolism By Lactobacillus Paracasei BY2 and Its Embedding Delivery

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