Protective effects of l-carnitine and alpha-lipoic acid in rats with adjuvant arthritis

Taştekin, Nurettin; Aydoğdu, Nurettin; Dökmeci, Dikmen; Usta, Ufuk; Birtane, Murat; Erbas, Hakan; Türe, Mevlüt

doi:10.1016/j.phrs.2007.07.008

Cited by 54 publications

(43 citation statements)

References 44 publications

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“…The high activity of erythrocyte SOD and the reduction in GPx activity in the arthritic control shown in the present study agree with the work of Tuncer et al (1999) and Tastekin et al (2007). The increase in SOD induced the scavenging of the superoxide ione into H 2 O 2 , a more potent reactive oxygen species, which may be accumulated due to a reduction in GPx resulting in increased lipid peroxidation which is reflected in the significant increase in MDA in the present study.…”

Section: Discussionsupporting

confidence: 92%

Role of <i>Bifidobacterium bifidum</i> and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Al‐Okbi¹,

Mohamed²,

Donya³

et al. 2011

Grasas y Aceites

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Section: Discussionsupporting

confidence: 92%

Role of <i>Bifidobacterium bifidum</i> and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Al‐Okbi¹,

Mohamed²,

Donya³

et al. 2011

Grasas y Aceites

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“…EVALUATIoN oF THE ANTI-INFLAMMAToRy AND ANTI-ARTHRITIC EFFECTS oF SoME PLANT ExTRACTS agreement with the results of Tastekin et al (2007). The administration of methanol extract of sage, celery and eucalyptus to arthritic rats produced significant improvement in inflammatory and lipid peroxidation biomarkers together with a reduction in inflammation thickness.…”

Section: Discussionsupporting

confidence: 83%

Evaluation of the anti-inflammatory and anti-arthritic effects of some plant extracts

Abdel-Moein¹,

Abdel-Moniem²,

Mohamed³

et al. 2011

Grasas y Aceites

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365plant extracts with different degrees ranging from 47 to 62%. The methanol extract of celery, sage and eucalyptus showed improvement in the level of plasma malondialdehyde, tumor necrosis factor-α and uric acid and also showed significant improvements in body weight and total food intake. The methanol extract of celery, sage and eucalyptus showed complete safety for liver and kidney functions. α-Linolenic acid and linoleic acid were present in all the studied plants. Stigmasterol and b-sitosterol were present in all the studied plants. KEY-WORDS:Anti-arthritic -Anti-inflammatory -Celery -Eucalyptus sage -Sweet basil. INTRODUCTIONRheumatoid arthritis (RA) is one of the major human autoimmune diseases affecting about 1 per cent of the adult population (Lipsky, 2005). The disease is characterized by inflammation of the synovial tissue and damage to the cartilage and bone of the joints, leading to severe deformities (Brennan & McInnes, 2008;Gorman & Cope, 2008). The drugs that inhibit inflammatory reactions are a vital component of the therapeutic arsenal against RA (Kremers et al., 2004). However, the adverse reactions and toxicity associated with the use of these drugs have expeditiously promoted the use of natural plant products or procedures belonging to the diverse traditional systems of medicine by patients with RA (Nozaki et al., 2006;Chang et al., 2010) and other chronic inflammatory disorders (Salvioli et al., 2007;Jung et al., 2007;Alleva et al., 2010). This growing trend warrants a continuous search for new natural anti-arthritic products. Adjuvant-induced arthritis (AIA) is a wellestablished model of rheumatoid arthritis that can be induced in rats by an intradermal injection of Freund's adjuvant (Holmdahl et al., 2001). The AIA model reproduces most of the bone changes found in RA (Holmdahl et al., 2001), including inflammatory bone loss, which has been linked to an increased risk of fracture (Joffe & Epstein, 1991). The role of plant products in various diseases has been known RESUMEN Evaluación de los efectos anti-inflamatorio y antiartrítico de algunos extractos de plantasEl objetivo de la presente investigación ha sido estudiar la actividad anti-inflamatoria de flores de albahaca dulces, hojas de eucalipto, hojas de apio y salvia. Se ha estudiado el efecto sobre la inflamación aguda de extractos metanólicos de apio, salvia y eucalipto y sobre la artritis inducida en ratas. Se han evaluado los efectos de los extractos metanólicos de apio, salvia y eucalipto sobre los parámetros bioquímicos determinados en la artritis inducida y su seguridad en las funciones del hígado y el riñón. Se han estudiado los ácidos grasos, hidrocarburos y fitoesteroles de todas las plantas objeto de la investigación. Los resultados han revelado una actividad antiinflamatoria de los extractos de las plantas estudiadas con diferentes grados entre un 47 y un 62%. Los extractos metanólico de apio, de salvia y de eucalipto han mostrado una mejoría de los niveles de malondialdehído en plasma, factor de necrosis tumoral α y de á...

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“…The present study show that MnSOD and PRX2 are more abundant in SFs of RA or OA, which suggests that they may play a protective role against oxidative stress in inflammatory arthritis. Furthermore, antioxidants and oxidative enzymes have been shown to ameliorate arthritis in animal models [18]. MnSOD that is upregulated to a higher level in OA than that in RA implied that inadequate control of ROS had been involved in the pathophysiology of RA.…”

Section: Discussionmentioning

confidence: 99%

Analyses of differential proteome of human synovial fibroblasts obtained from arthritis

Zhou

Wang

et al. 2008

Clin Rheumatol

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There is mounting evidence indicating that the synovial fibroblasts (SFs) contribute to the pathogenesis of rheumatoid arthritis (RA). The present study showed the differential proteins expression pattern of SFs from patients with RA or osteoarthritis (OA) and healthy control. Cellular proteins of cultured SFs were subjected to 2-DE and visualized by silver nitrate staining. A total of 49 spots that were statistically and differentially overexpressed in RA or OA in comparison to healthy ones were identified by MALDI-TOF-MS, and 25 proteins were successfully identified. Western blot was used to further verify some of the differential proteins. These proteins included enzymatic and structural proteins, signal transduction proteins, calcium binding protein, etc. From all of the identified proteins, a number of proteins have been implicated that involved in the healthy or pathological SFs function (e.g., S100A4, S100A10, cathepsin D) or that have potential diagnostic and prognostic value for RA (α-enolase and TPI) or that may be the new therapeutic targets (Annexin, SOD, PRX).

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Protective effects of l-carnitine and alpha-lipoic acid in rats with adjuvant arthritis

Cited by 54 publications

References 44 publications

Role of <i>Bifidobacterium bifidum</i> and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Role of <i>Bifidobacterium bifidum</i> and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis.

Evaluation of the anti-inflammatory and anti-arthritic effects of some plant extracts

Analyses of differential proteome of human synovial fibroblasts obtained from arthritis

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