Protective effects of ibuprofen against caustic esophageal burn injury in rats

Herek, Özkan; Karabul, Murat; Yenisey, Çiğdem; Erkuş, Muhan

doi:10.1007/s00383-010-2618-1

Cited by 11 publications

(10 citation statements)

References 40 publications

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“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

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Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.

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Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

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“…The ideal application is to give slow and small doses in the form of instillation (Demirbilek et al 1994). In different studies, NaOH solution (10–40%; Herek et al, 2010) was applied in the lumen between 60 s (Senturk et al, 2010) and 3 min intervals (Duman et al, 2011). In our study, NaOH solution was applied at a strength of 37.5% over a period of 60 s, and then the solution was aspirated.…”

Section: Discussionmentioning

confidence: 99%

A novel model approach for esophageal burns in rats

et al. 2013

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“…Although several treatment protocols have been devised and used to accomplish anti-inflammatory and anti-fibrogenic actions, the benefit and standardization of these treatment methods are still controversial [3]. Nowadays, the effects of many therapeutic agents in preventing esophageal stricture formation continue to be investigated in experimental caustic esophageal burn injury models [4,5].…”

Section: Introductionmentioning

confidence: 99%