Protective Effects of <i>Moringa oleifera</i> on HBV Genotypes C and H Transiently Transfected Huh7 Cells

Feustel, Sina; Ayón‐Pérez, Miriam Fabiola; Sandoval-Rodríguez, Ana; Rodríguez-Echevarría, Roberto; Contreras-Salinas, Homero; Armendáriz‐Borunda, Juan; Sánchez-Orozco, Laura V.

doi:10.1155/2017/6063850

Cited by 33 publications

(25 citation statements)

References 46 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A novel arabinogalactan, Moringa oleifera polysaccharide 1 (MOP-1), has been isolated from the leaves of MO showing strong antioxidant properties [20]. In addition, it has also been reported that MO leaves may be of use in viral [21] and bacterial infections [22]. In general, MO leaves have been reported to be of possible benefit for several chronic diseases including cardiovascular conditions, liver diseases, cancer, insulin resistance, and diabetes.…”

Section: Leavesmentioning

confidence: 99%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

View full text Add to dashboard Cite

Diabetes and related neurological complications are serious worldwide public health problems. The increasing number of affected individuals make it necessary to implement novel nutritional and therapeutic interventions. The tree Moringa oleifera (MO) has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties. These properties may be explained by the presence of numerous phytochemicals in the leaves, fruits, roots and, oil of the tree. The evidence for acute antihyperglycemic effects of MO extract on diabetic animal models seems to be robust, but more chronic and long-term studies are needed. In contrast, the hypoglycemic effects of MO on humans are not as clear. The scarce number of human studies, together with a diverse range of methodologies and MO doses, may explain this. In addition, evidence regarding changes in insulin levels due to MO intervention is ambiguous, both in animal and human studies. Therefore, more structured studies are needed to clarify if MO has an effect on insulin levels or activity.

show abstract

Section: Leavesmentioning

confidence: 99%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

View full text Add to dashboard Cite

show abstract

“…It facilitates phytate breakdown by action of phytase enzymes which lead to absorption of phosphorus [13]. Moringa oleifera plants treats Hepatitis B infection in humans [14].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of Moringa Oleifera Leaf Meal (Molm) Against Newcastle Disease in Broilers

Akram

Saleem

Farhab

et al. 2020

Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi

View full text Add to dashboard Cite

Moringa oleifera meal can serve as a natural antimicrobial agent and a feed supplement supplying nutrients for rural and commercial poultry. Recently Moringa have wide range of application as a medicine, protein supplement and as an antioxidant in poultry. Moringa mainly composed of carbohydrates (38%), 27%, protein (27%), moisture (6%) and fibre (18%). The present study was planned to check efficacy of Moringa oleifera leaf meal (MOLM) for immunomodulatory effects in Broilers whilst it has been established already that there isn’t any deleterious effect in M. oleifera which are found in chemical drugs. 144 birds were divided into 4 groups having 12 birds of each and subdivided into groups of 12. Such that treatment groups were D; receiving 0%, divided into replicates D1, D2, D3 while similar divisions of group A, B and C received 2, 4 and 6 % of MOLM infused in their feed as an additive supplement. The birds were slaughtered at 14th, 21th and 35th day and blood as well as serum was collected for the sake of hematological parameters and to check the antibody titre using HA/HI checking for effectiveness of immune system at producing antibodies against Newcastle Disease, which the birds were vaccinated against. Maximum weight gain was observed in broilers fed diet B while lowest weight gain was observed in birds fed diet D, which was a control group. Maximum feed intake was observed in broilers fed diet A while lowest feed intake was observed in birds fed diet D, which was a control group. Significantly, better feed conversion ratio was observed in birds fed diet B whereas the highest feed conversion ratio (FCR) was observed in broilers fed diet without Moringa oleifera supplementations. The highest antibody level was found in the birds of group B, while lowest level was found in the broilers of group D. Maximum spleen weight was observed in birds fed diet group C and D while lowest weight was observed in birds fed diet A. Maximum thymus weight was observed in birds fed diet B and C. Bursa weight was observed in birds fed diet A and D while lowest weight was observed in birds fed diet C. There was no significant difference (P>0.05) on hematological profile among groups. All the collected data was analyzed by statistical software Minitab Inc. 2010. Minitab Statistical Software (Release 17). State College, PA. The data thus, obtained was subjected to CRD for analysis of variance. It was concluded that Moringa infused in feed does enhance immune parameters of broilers, making them better at combating diseases, making Moringa a viable dietary supplement for commercial poultry. It was also found that the optimal dose of Moringa in MOLM is 4g/kg feed

show abstract

“…From this point of view, to evaluate antiretroviral activity of different extracts of M. oleifera, Nworu and collaborators [321], used a specific antiviral screening technique, demonstrating that three different extracts of M. oleifera were able to inhibit infectious power of HIV-1 lentiviral particles. In a recent research, [322] the antiviral activity of aqueous extracts of M. oleifera leaves was evaluated on Huh7 cell line. In particular, these extracts were able to modulate the pgRNA levels and HBsAg secretion positively in Huh7 cells transfected with genotypes C and H of HBV.…”

Section: Moringamentioning

confidence: 99%

Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview

et al. 2021

View full text Add to dashboard Cite

To date, the leading causes of mortality and morbidity worldwide include viral infections, such as Ebola, influenza virus, acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) and recently COVID-19 disease, caused by the SARS-CoV-2 virus. Currently, we can count on a narrow range of antiviral drugs, especially older generation ones like ribavirin and interferon which are effective against viruses in vitro but can often be ineffective in patients. In addition to these, we have antiviral agents for the treatment of herpes virus, influenza virus, HIV and hepatitis virus. Recently, drugs used in the past especially against ebolavirus, such as remdesivir and favipiravir, have been considered for the treatment of COVID-19 disease. However, even if these drugs represent important tools against viral diseases, they are certainly not sufficient to defend us from the multitude of viruses present in the environment. This represents a huge problem, especially considering the unprecedented global threat due to the advancement of COVID-19, which represents a potential risk to the health and life of millions of people. The demand, therefore, for new and effective antiviral drugs is very high. This review focuses on three fundamental points: (1) presents the main threats to human health, reviewing the most widespread viral diseases in the world, thus describing the scenario caused by the disease in question each time and evaluating the specific therapeutic remedies currently available. (2) It comprehensively describes main phytochemical classes, in particular from plant foods, with proven antiviral activities, the viruses potentially treated with the described phytochemicals. (3) Consideration of the various applications of drug delivery systems in order to improve the bioavailability of these compounds or extracts. A PRISMA flow diagram was used for the inclusion of the works. Taking into consideration the recent dramatic events caused by COVID-19 pandemic, the cry of alarm that denounces critical need for new antiviral drugs is extremely strong. For these reasons, a continuous systematic exploration of plant foods and their phytochemicals is necessary for the development of new antiviral agents capable of saving lives and improving their well-being.

show abstract

Protective Effects of Moringa oleifera on HBV Genotypes C and H Transiently Transfected Huh7 Cells

Cited by 33 publications

References 46 publications

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

Immunomodulatory Effects of Moringa Oleifera Leaf Meal (Molm) Against Newcastle Disease in Broilers

Phytochemicals from Plant Foods as Potential Source of Antiviral Agents: An Overview

Contact Info

Product

Resources

About