Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress

Ji, Xituan; Tian, Ye; Xie, Keliang; Liu, Weiping; Qu, Yan; Fei, Zhou

doi:10.1016/j.jss.2011.12.038

Cited by 48 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecular hydrogen was reported to activate PGC-1α (28), which enhances mitochondrial activity (29), thereby rescuing exhausted CD8 + T cells with inactive mitochondria following progressive loss of PGC-1α (15). Therefore, the present study investigated whether hydrogen gas alters the proportion of PD- CD8 + T cell ratio was found to be an independent predictor of poor PFS (HR, 6.459; 95% CI, 2.384-17.50; P<0.0001) and OS (HR, 2.957; 95% CI, 1.185-7.378; P=0.020).…”

Section: Hydrogen Gas Reduces the Proportion Of Pd-1 + Cd8 + T Cells mentioning

confidence: 99%

“…Accordingly, hydrogen is now believed to reduce oxidative stress and ischemia-reperfusion injury in the brain, spinal cord (10), myocardium (11), intestinal epithelium (12), retina, testes (13) and kidneys (14). Hydrogen has been used to treat various states associated with oxidative stress, including trauma (15), neurodegenerative disease (16), inflammatory disease (17), organ transplantation, metabolic syndrome (18), diabetes mellitus (19), sepsis (20), burns (21), adverse reactions to chemotherapy (22), radiation injury (23), hearing disorders and preeclampsia (24). There are several studies on the preventive and therapeutic effects of hydrogen on various diseases, including cancer (25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis

Akagi

Baba

2018

Oncol Rep

View full text Add to dashboard Cite

Exhausted cluster of differentiation (CD)8 + T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC-1α, the present study investigated whether it restores exhausted CD8 + T cells to improve prognosis in patients with stage IV colorectal cancer. A total of 55 patients with histologically and clinically diagnosed stage IV colorectal carcinoma were enrolled between July 2014 and July 2017. The patients inhaled hydrogen gas for 3 h/day at their own homes and received chemotherapy at the Tamana Regional Health Medical Center (Tamana, Kumamoto, Japan). The CD8 + T cells were isolated from the peripheral blood and their phenotype was analyzed by flow cytometry. It was found that exhausted terminal programmed cell death 1 (PD-1) + CD8 + T cells in the peripheral blood are independently associated with worse progression-free survival (PFS) and overall survival (OS). Notably, hydrogen gas decreased the abundance of exhausted terminal PD-1 + CD8 + T cells, increased that of active terminal PD-1 -CD8 + T cells, and improved PFS and OS times, suggesting that the balance between terminal PD1 + and PD1 -CD8 + T cells is critical for cancer prognosis. Therefore, a novel system for patient classification (category 1-4) was developed in the present study based on these two indices to assist in predicting the prognosis and therapeutic response.Collectively, the present results suggested that hydrogen gas reverses imbalances toward PD-1 + CD8 + T cells to provide an improved prognosis.

show abstract

Section: Hydrogen Gas Reduces the Proportion Of Pd-1 + Cd8 + T Cells mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis

Akagi

Baba

2018

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…Inhalation of H 2 gas suppresses the increase in oxidative products and enhances the enzymatic activities of endogenous antioxidants (superoxide dismutase and catalase) in brain tissue, leading to the protective efficacy of H 2 treatment in a rat model of TBI [87]. Injection of HS was also shown to be effective against TBI via reducing oxidative stress [88]. Dohi et al .…”

Section: Other Neurological Disordersmentioning

confidence: 99%

Molecular Hydrogen as a Neuroprotective Agent

Iketani¹,

Ohsawa

2017

View full text Add to dashboard Cite

Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.

show abstract

“…Ultimately, ROS depression of cerebral metabolism can have long-term consequences manifesting in chronic neurodegeneration and behavioral abnormalities (173). Proton therapy through use of hydrogen infused saline can limit the damage to endothelial cells by preventing BBB disruption and the formation of ROS (74). Another means of limiting oxidative stress is maintenance of mitochondrial homeostasis (130).…”

Section: Vasospasms Subarachnoid Hemorrhage Edema and Ischemic Hypoxiamentioning

confidence: 99%

Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury

Logsdon

Lucke‐Wold

Turner

et al. 2015

Comprehensive Physiology

125

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is a primary effect that can lead to a host of secondary injury cascades. The primary effects of TBI are rapidly occurring while secondary effects can be activated at later time points and may be more amenable to targeting. Primary effects of TBI include diffuse axonal shearing, changes in blood brain barrier (BBB) permeability, and brain contusions. These mechanical events, especially changes to the BBB, can induce calcium perturbations within brain cells producing secondary effects, which include cellular stress, inflammation, and apoptosis. These secondary effects can be potentially targeted to preserve the tissue surviving the initial impact of TBI. In the past, TBI research had focused on neurons without any regard for glial cells and the cerebrovasculature. Now a greater emphasis is being placed on the vasculature and the neurovascular unit following TBI. A paradigm shift in the importance of the vascular response to injury has opened new avenues of drug treatment strategies for TBI. However, a connection between the vascular response to TBI and the development of chronic disease has yet to be elucidated. Long-term cognitive deficits are common amongst those sustaining severe or multiple mild TBIs. Understanding the mechanisms of cellular responses following TBI is important to prevent the development of neuropsychiatric symptoms. With appropriate intervention following TBI, the vascular network can perhaps be maintained and the cellular repair process possibly improved to aid in the recovery of cellular homeostasis.

show abstract

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress

Cited by 48 publications

References 38 publications

Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis

Hydrogen gas restores exhausted CD8+ T�cells in patients with advanced colorectal cancer to improve prognosis

Molecular Hydrogen as a Neuroprotective Agent

Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury

Contact Info

Product

Resources

About