Protective effects of hydrogen-rich saline on ulcerative colitis rat model

He, Jinghu; Xiong, Shao-Hu; Zhang, Jianquan; Wang, Junwu; Sun, Aijun; Mei, Xiang; Sun, Xuejun; Zhang, Chuansen; Wang, Qiang

doi:10.1016/j.jss.2013.05.047

Cited by 23 publications

(18 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three years later, the same group demonstrated that intestinal grafts preloaded with H 2 exhibited superior morphology and function in rodent intestinal transplants, ultimately facilitating recipient survival [ 70 ]. HS treatment also alleviated colonic mucosal damage [ 143 ] and postoperative ileus [ 144 ] in murine models.…”

Section: Preventive and Therapeutic Applications Of Hmentioning

confidence: 99%

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

et al. 2017

View full text Add to dashboard Cite

Since the 2007 discovery that molecular hydrogen (H2) has selective antioxidant properties, multiple studies have shown that H2 has beneficial effects in diverse animal models and human disease. This review discusses H2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H2 delivery approaches; and summarizes recent progress toward H2 applications in human medicine. We also discuss remaining questions in H2 therapy, and conclude with an appeal for a greater role for H2 in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.

show abstract

Section: Preventive and Therapeutic Applications Of Hmentioning

confidence: 99%

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Accordingly, IPEC-J2 is a good model to explore cytotoxic properties of mycotoxins on intestinal epithelial cells in vitro. Recent reports showed that hydrogen can remit some serious intestinal diseases with different methods of intake into the body [14][15][16]. In addition, its protective effects were demonstrated in some cell models in vitro with the use of H 2 -saturated medium [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study

Zheng

Yao

2019

Toxins

View full text Add to dashboard Cite

To explore the protective role of hydrogen gas (H 2 ) on oxidative damage and apoptosis in intestinal porcine epithelial cells (IPEC-J2) induced by deoxynivalenol (DON), cells were assigned to four treatment groups, including control, 5 µM DON, H 2 -saturated medium, and 5 µM DON + H 2 -saturated medium treatments. After 12 h of different treatments, the cell viability, biomarkers of cell redox states, and gene expression of antioxidant enzymes and apoptosis were observed and detected. Furthermore, caspase-3 and Bax protein expressions were measured by Western blot analysis. Our results demonstrated that the 5 µM DON significantly caused cytotoxicity to IPEC-J2 cells by reducing cell viability and increasing lactate dehydrogenase release in culture supernatants. Moreover, DON treatments significantly increased levels of 8-hydroxy-2 -deoxyguanosine, 3-nitrotyrosine, and malonaldehyde; however, they decreased total superoxide dismutase and catalase activities and downregulated messenger RNA (mRNA) expression related to antioxidant enzymes in cells. The 5 µM DON treatment also downregulated Bcl-2 expression and upregulated caspase-3 and Bax expression. However, the H 2 -saturated medium significantly improved cell growth status and reversed the change of redox states and expression of genes and proteins related to apoptosis induced by DON in IPEC-J2 cells. In conclusion, H 2 could protect IPEC-J2 cells from DON-induced oxidative damage and apoptosis in vitro.

show abstract

“…Intraperitoneal administration of hydrogen in 10 -20 ml/Kg of H 2 -enriched saline solutions for a period of 2 weeks diminished various macroscopic and microscopic indicators of colonic mucosal damage. An interesting aspect of this work is that it also demonstrated that, in addition to its antioxidant role, hydrogen inhibited the expression of vascular endothelial growth factor [284]. In neonatal rat models, it has been shown that hydrogen-rich saline reduced the incidence of necroziting enterocolitis (NEC) from 85% to 54.5%, while increasing the survival rate from 25% to 68.2% (p < 0.05) [265].…”

Section: Hydrogen In Inflammatory Diseasesmentioning

confidence: 92%

“…The role of hydrogen in reducing inflammation in specific organs has also been studied in detail in several animal models. At the gastrointestinal level, it has been reported that hydrogen-rich saline has a protective effect, for example, in ulcerative colitis in rats induced by acetic acid [284]. Intraperitoneal administration of hydrogen in 10 -20 ml/Kg of H 2 -enriched saline solutions for a period of 2 weeks diminished various macroscopic and microscopic indicators of colonic mucosal damage.…”

Section: Hydrogen In Inflammatory Diseasesmentioning

confidence: 98%

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Nicolson¹,

Ferreira²,

Settineri³

et al. 2016

IJCM

View full text Add to dashboard Cite

Here we review the literature on the effects of molecular hydrogen (H2) on normal human subjects and patients with a variety of diagnoses, such as metabolic, rheumatic, cardiovascular and neurodegenerative and other diseases, infections and physical and radiation damage as well as effects on aging and exercise. Although the effects of H2 have been studied in multiple animal models of human disease, such studies will not be reviewed in depth here. H2 can be administered as a gas, in saline implants or infusions, as topical solutions or baths or by drinking H2-enriched water. This latter method is the easiest and least costly method of administration. There are no safety issues with hydrogen; it has been used for years in gas mixtures for deep diving and in numerous clinical trials without adverse events, and there are no warnings in the literature of its toxicity or longterm exposure effects. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular damage.

show abstract

Protective effects of hydrogen-rich saline on ulcerative colitis rat model

Cited by 23 publications

References 39 publications

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study

Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine

Contact Info

Product

Resources

About