2014
DOI: 10.3390/ijms150915073
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Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine

Abstract: Hericium erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H. erinaceus mycelium could act as an anti-inflammatory agent to bring about neuroprotection using a model of global ischemic stroke and the mechanisms involved. Rats were treated with H. erinaceus mycelium and its isolated diterpenoid derivative, erinacine A, after ischemia reperfusion brain injuries caused by the occlusion of the two commo… Show more

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Cited by 92 publications
(86 citation statements)
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“…Stroke is the primary cause of long-term disability and death worldwide (Iadecola & Anrather 2011;Lee et al 2014). Ischemic stroke caused by arterial occlusions constitutes approximately 80% of all stroke cases (Wang et al 2010a).…”
Section: Introductionmentioning
confidence: 99%
“…Stroke is the primary cause of long-term disability and death worldwide (Iadecola & Anrather 2011;Lee et al 2014). Ischemic stroke caused by arterial occlusions constitutes approximately 80% of all stroke cases (Wang et al 2010a).…”
Section: Introductionmentioning
confidence: 99%
“…The analytical column used was a COSMOSIL 5C18-AR-II (250 × 4.6 mm; particle size 5 µm, Nacalai USA, Inc., Kyoto, Japan). Extraction of 5 mg/kg H. erinaceus erinacine A with 85% ethanol was confirmed and quantified by HPLC [10, 11]. The erinacine A chemical compounds reported in this article (PubChem CID: 10410568) are shown in Fig.…”
Section: Methodsmentioning
confidence: 99%
“…Erinacine A (Fig. 1)-enriched H. erinaceous mycelia, which exhibit well-known anti-inflammatory and anticancer effects [10-13], have been extensively investigated and proposed to promote a decrease in cell viability and enhance apoptosis in various cancer cells. Moreover, our previous studies indicated that H. erinaceus mycelium and extracted erinacine A could be used to investigate the in vitro and in vivo antitumor activity through cell cycle arrest in the G1 phase of the human colorectal cancer cells involved in the generation of ROS and the activation of the p70S6K/NF-kB signaling pathway, which leads to p21 expression and inactivation of cdk2/cyclin E and cdk4/cyclin D1 [12].…”
Section: Introductionmentioning
confidence: 99%
“…Bioactive compounds extracted from its fruiting body or mycelium ( Figure 1) have been demonstrated to possess antioxidative [20], antidiabetic [21], anticancer [22,23], anti-inflammatory [24], antimicrobial [23], antihyperglycemic [25], and hypolipidemic properties [26]. Moreover, H. erinaceus has been used to treat cognitive impairments [27], Alzheimer's disease [28], Parkinson's disease [29], ischemic stroke [30], and presbycusis [14]. Recently, the present research on H. erinaceus has been focused on its antidepressant-like effects for the treatment of depressive disorder [31][32][33].…”
Section: Introductionmentioning
confidence: 99%