Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats

Choi, Won-Sik; Jang, Do-Yoen; Lee, Gyung-Rak; Kim, Seung-Han

doi:10.5762/kais.2012.13.4.1769

Journal of the Korea Academia-Industrial cooperation Society

2012

DOI: 10.5762/kais.2012.13.4.1769

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Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats

Won-Sik Choi¹,

Do-Yoen Jang²,

Gyung-Rak Lee³

et al.

Abstract: The purpose of this study is to evaluate the gastric mucosal damage effect by Hericium erinaceus cultibated with Artemisia capillaris (HEAC) with 0.15 M HCl in ethanol in rats. Among them, 80% ethanol extract showed potent inhibitory effect (67.7%) on gastritis. Using solvent fractionation, 80% ethanol extract of HEAC was separated into five fractions with n-hexane, methylene chloride, ethyl acetate, n-butanol and water. As a result, fractions obtained with methylene chloride exhibited strong inhibitory effect… Show more

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2019

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Preventive Effect of the Water Extract of Agrimonia pilosa Ledeb and Micronucleus Assay-Based Evaluation of Genotoxicity in Gastritis Animal Models

Nho¹,

Jang²,

Lee³

et al. 2019

KJMCS

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Background: Agrimonia pilosa Ledeb has been used as a traditional medicine for the treatment of hematuresis and uterine bleeding in Korea. It has been reported to have anti-obesity, anti-diabetes and anti-inflammaotry effect by regulating the inflammatory signaling pathway. However, the preventive effect of Agrimonia pilosa Ledeb on gastritis has not been elucidated. Thus, in the present study, we evaluated the effects of the water extract of Agrimonia pilosa Ledeb (APW) using HCl/EtOH-induced gastritis rat models. Method and Results: Gastritis was induced in rats by HCl/EtOH administration. The rats in each group were orally administered with two doses of APW (100 and 500 ㎎/㎏). Omeprazole was used as a positive control drug. An enzyme-linked immunosorbent assay (ELISA) was used to measure the prostaglandin E 2 (PGE 2 ) levels in stomach. The treatment with 500 ㎎/㎏ APW reduced the gastric ulcer area. The APW treatment prevented a decreased in PGE 2 concentration induced by HCl/EtOH in rats. In the micronucleus test, the ratio of micronucleated polychromatic erythrocytes to polychromatic erythrocytes showed no significant change in the APW-treated group compared with the control group. Conclusions: These results indicate that APW could be used to prevent the gastritis caused by the HCl/EtOH-induced damage to stomach lining. In addition, the APW treatment showed no significant change in results of the micronucleus test. However, further experiments are required to determine how APW influenced the secretion of mucus and gastric acid using the chromosome aberration test and bacterial reverse mutation assay.

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Preventive Effect of the Water Extract of Agrimonia pilosa Ledeb and Micronucleus Assay-Based Evaluation of Genotoxicity in Gastritis Animal Models

Nho¹,

Jang²,

Lee³

et al. 2019

KJMCS

View full text Add to dashboard Cite

show abstract

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Protective Effects of HEAC and its Primary Active Compound on HCl-ethanol Induced Gastritis in Rats

Cited by 1 publication

References 23 publications

Preventive Effect of the Water Extract of Agrimonia pilosa Ledeb and Micronucleus Assay-Based Evaluation of Genotoxicity in Gastritis Animal Models

Preventive Effect of the Water Extract of Agrimonia pilosa Ledeb and Micronucleus Assay-Based Evaluation of Genotoxicity in Gastritis Animal Models

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