Protective Effects of Green Tea Polyphenol AgainstRenal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

Wang, Haidong; Li, Deyuan; Hu, Zhongqiang; Zhao, Siming; Zheng, Zhejun; Li, Wei

doi:10.14348/molcells.2016.2170

Cited by 57 publications

(37 citation statements)

References 31 publications

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“…In addition to p53, MAPK family members are activated by ROS (30)(31)(32). MAPKs, including extracellular signal-regulated kinase (Erk), c-Jun N-terminal kinase (JNK) and p38, are activated in response to diverse stimuli, and serve important roles in mammalian cells by regulating cell apoptosis, differentiation, migration and proliferation (33).…”

Section: Introductionmentioning

confidence: 99%

Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway

Lan

Yuan

Cai

2017

Molecular Medicine Reports

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Sulforaphane (SFN) has been revealed to inhibit the growth and induce apoptosis of cancer cells. However, the detailed anticancer effects of SFN on p53‑deficient colon cancer cells has yet to be clearly elucidated. The present study employed p53‑deficient SW480 cells to establish an SFN‑induced in vitro model of apoptosis. The critical events leading to apoptosis were then evaluated in SFN‑treated p53‑deficient SW480 cells, by performing an MTT assay, flow cytometry, western blotting and ELISA. The results demonstrated that SFN at concentrations of 5, 10, 15 and 20 µM induced mitochondria‑associated cell apoptosis, which was further confirmed by disruption of the mitochondrial membrane potential, an increase in the Bax/Bcl‑2 ratio, as well as activation of caspase‑3, ‑7 and ‑9. In addition, SFN‑induced apoptosis was associated with an increase in the generation of reactive oxygen species (ROS), and the activation of extracellular signal‑regulated kinases (Erk) and p38 mitogen‑activated protein kinases. However, SFN did not induce expression of the p53 family member, p73. SFN‑induced apoptosis was subsequently confirmed to be ROS‑dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)‑Erk and p‑p38, completely or partially attenuated the SFN‑induced reduction in SW480 cell viability. In addition, the results demonstrated that even at the lowest concentrations (5 µM), SFN increased the sensitivity of p53‑proficient HCT‑116 cells to cisplatin. In conclusion, the results suggest that SFN may induce apoptosis in p53‑deficient SW480 cells via p53/p73‑independent and ROS‑Erk/p38‑dependent signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway

Lan

Yuan

Cai

2017

Molecular Medicine Reports

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“…Tea also exhibits some other health functions in vitro and in vivo, as shown in Tables 2 and 3, respectively. For instance, tea could protect against kidney injuries induced by a high-fat diet, proline, gentamicin, lead, and ischemia-reperfusion [178][179][180][181][182][183]. In addition, tea has exhibited the neuro-protective effect, in terms of protecting against age-related neuro-degenerative disorders, depression and regulating the circadian clock [184][185][186][187][188][189][190].…”

Section: Other Health Functionsmentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

237

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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“…Their beneficial effect against many diseased conditions affecting different major organs already has been well established. 63,64 Polyphenols can be divided into different classes according to specific biological properties. Polyphenols can be extracted from different natural sources like plants, fruits and vegetables.…”

Section: Effect Of Polyphenols Against Lead Intoxicationmentioning

confidence: 99%

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

Bhattacharjee¹,

Kulkarni²,

Habbu³

et al. 2018

Int. Res. J. Pharm.

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Lead is having wide application in day to day life such as building materials, , and sea fish are also commonly intoxicated by lead. Direct or edible exposure of lead is the very common cause of lead toxicity. Chronic toxicity associated with lead is more hazardous compared to acute toxicity. Young children are especially vulnerable to the harmful effects of lead and can suffer from permanent adverse health effects, particularly affecting the brain and nervous system development. Lead causes longterm toxicity in adults, including increased risk of hypertension and kidney damage. Exposure to high lead in pregnant women levels can cause miscarriage, stillbirth, premature birth, low birth weight and minor malformations. Lead is responsible for generation of free radicals which induces a broad range of physiological, biochemical and behavioral dysfunctions. Lead exposure is having detrimental effects on almost all the major organ system which is a major contributory factor for incremental mortality and morbidity. Beneficial effects of polyphenol in lead induced toxicity have been noticed. The probable reason by which it may show the protection is scavenging of reactive oxygen species, generated by lead. Moreover, it is reported that they are also responsible for detoxification by removal of accumulated heavy metals from major organs.

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Protective Effects of Green Tea Polyphenol AgainstRenal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

Cited by 57 publications

References 31 publications

Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway

Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Detrimental Effects of Lead on Human Health and Protective Effect by Natural Polyphenols: A Review

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