Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway

Jiang, Chen; Liu, Gen-Zhe; Sun, Qi; Zhang, Fan; Liu, Chu-Yin; Lin, Yuan; Zhao, Xueqian; Wang, Yongjun; Jia, Yu-Song

doi:10.1016/j.lfs.2018.11.022

Cited by 28 publications

(26 citation statements)

References 41 publications

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“…TNF-α is the earliest and most important mediator in the inflammation process, and IL-6 promotes the accumulation of acute proteins and T cells at the inflammation site. 52,53 IL-1β is mainly expressed by innate immune cells in inflammatory injury, and its precursor intracellular processing depends on caspase-1. 54 INF-γ inhibits Th2 development, and IL-10 inhibits Th1 reaction, and while these two normally regulate each other, this homeostasis is destroyed in the process of inflammation.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice

Sheng

Tan

et al. 2021

DDDT

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Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice

Sheng

Tan

et al. 2021

DDDT

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“…Yu et al [ 148 ] showed that the GSs Rg1 regulates Wnt/ β -catenin signalling, promotes the proliferation of rat NP cells and the production of collagen II and aggrecan, and reduces cell apoptosis. Chen et al [ 149 ] reported that the GSs Rg3 inhibits the NF- κ B signalling pathway and reduces the production of ROS in NP cells, thereby promoting cell proliferation and ECM anabolism, while reducing apoptosis.…”

Section: Natural Pharmacological Productsmentioning

confidence: 99%

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Chen

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Intervertebral disc degeneration (IDD) is one of the main causes of low back pain (LBP), which severely reduces the quality of life and imposes a heavy financial burden on the families of affected individuals. Current research suggests that IDD is a complex cell-mediated process. Inflammation, oxidative stress, mitochondrial dysfunction, abnormal mechanical load, telomere shortening, DNA damage, and nutrient deprivation contribute to intervertebral disc cell senescence and changes in matrix metabolism, ultimately causing IDD. Natural products are widespread, structurally diverse, afford unique advantages, and exhibit great potential in terms of IDD treatment. In recent years, increasing numbers of natural ingredients have been shown to inhibit the degeneration of nucleus pulposus cells through various modes of action. Here, we review the pharmacological effects of natural products on nucleus pulposus cells and the mechanisms involved. An improved understanding of how natural products target signalling pathways will aid the development of anti-IDD drugs. This review focuses on potential IDD drugs.

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“…Ginsenoside Rg3 has been reported to inhibit NF‐κB activation and pro‐inflammatory cytokine IL‐1β secretion . These findings promoted us to investigate the possible mechanism of Rg3 in controlling inflammasome activation.…”

Section: Introductionmentioning

confidence: 96%

“…5,17 These findings promoted us to investigate the possible mechanism of Rg3 in controlling inflammasome activation. 5,17 These findings promoted us to investigate the possible mechanism of Rg3 in controlling inflammasome activation.…”

Section: Introductionmentioning

confidence: 99%

“…Ginsenoside Rg3 has been reported to inhibit NF-κB activation and pro-inflammatory cytokine IL-1β secretion. 5,17 These findings promoted us to investigate the possible mechanism of Rg3 in controlling inflammasome activation. In this study, we found that Rg3 exerted its anti-inflammatory activity through inhibiting NLRP3 inflammasome assembly.…”

Section: Introductionmentioning

confidence: 99%

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Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly

et al. 2019

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Ginsenoside Rg3 is one of the main constituents of Panax ginseng. Compelling evidence has demonstrated that ginsenoside Rg3 is capable of inhibiting inflammation.However, the mechanism mediating its anti-inflammatory effects remain unclear.Here we show that ginsenoside Rg3 blocks IL-1β secretion and caspase-1 activation through inhibiting LPS priming and the NLRP3 inflammasome activation in human and mouse macrophages. Rg3 specifically inhibits activation of NLRP3 but not the NLRC4 or AIM2 inflammasomes. In addition, Rg3 has no effect on upstream regulation of NLRP3 inflammasome, such as K + efflux, ROS production, or mitochondrial membrane potential. Mechanistically, Rg3 abrogates NEK7-NLRP3 interaction, and subsequently inhibits NLRP3-ASC interaction, ASC oligomerization, and speckle formation. More importantly, Rg3 can reduce IL-1β secretion induced by LPS in mice and protect mice from lethal endotoxic shock. Thus, our findings reveal an anti-inflammatory mechanism for Rg3 and suggest its potential use in NLRP3-driven diseases. K E Y W O R D Santi-inflammation, ginsenoside Rg3, inflammasome, NLRP3 inflammasome | 209 SHI et al. SUPPORTING INFORMATIONAdditional supporting information may be found online in the Supporting Information section.

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Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway

Cited by 28 publications

References 41 publications

Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice

Lactobacillus plantarum KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration

Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly

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