Protective effects of four Iranian medicinal plants against free radical-mediated protein oxidation

Bahramikia, Seifollah; Ardestani, Amin; Yazdanparast, Razieh

doi:10.1016/j.foodchem.2008.11.054

Cited by 65 publications

(38 citation statements)

References 27 publications

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“…This was the first study on the shoots of T. polium. Finally, in the latest study performed, the effect of an ethyl acetate extract of T. polium on 2-deoxy-D-ribose (dRib)-induced oxidative stress and apoptosis in K562 cells was investigated (Yazdanparast and Ardestani, 2009). Based on this study, Salvigenin Aerial parts Rizk et al, 1986;Harborne et al, 1986 5 Cirsiliol Aerial parts Rizk et al, 1986;Verykokidou-Vitsaropoulou and Vajias, 1986;Harborne et al, 1986;Carreiras et al, 1989 6 Eupatorin Aerial parts Verykokidou-Vitsaropoulou and Vajias, 1986 7 Apigenin-4', 7-dimethylether Aerial parts Verykokidou-Vitsaropoulou and Vajias, 1986 8 Apigenin Aerial parts Harborne et al, 1986;Carreiras et al, 1989;Sharififar et al, 2009 9 6-Hydroxyluteolin Aerial parts Harborne et al, 1986 10 Apigenin 5-galloylglucoside Aerial parts Kawashty et al, 1999 11 Apigenin 7-glucoside Aerial parts Kawashty et al, 1999 12 Vicenin-2 Aerial parts Kawashty et al, 1999 13 Rutin the ethyl acetate extract treatment of the dRib-induced cells at doses of 10, 25 and 50 mg/mL increased the intracellular GSH level to 124%, 145% and 191%, respectively, compared with extract-untreated cells.…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

Bahramikia

Yazdanparast

2012

Phytotherapy Research

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116

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Teucrium polium L. (family Lamiaceae) is a wild-growing flowering plant, found abundantly in South-Western Asia, Europe and North Africa. Traditionally, T. polium has been used for different pathological conditions such as gastrointestinal disorders, inflammations, diabetes and rheumatism. In traditional Iranian medicine (TIM), the tea of T. polium is used for treating many diseases such as abdominal pain, indigestion, common cold and type 2 diabetes. Based on this background, many studies have been followed for scientific confirmation of the above-mentioned properties. In this review, 100 articles published from 1970 to 2011 in the area of phytochemistry, pharmacology and toxicology of extracts and compounds isolated from T. polium have been evaluated. During the past 40 years, different classes of compounds have been isolated from various parts of T. polium of which the main groups are terpenoids and flavonoids. It has been found that these compounds possess a broad spectrum of pharmacological effects including antioxidant, anticancer, antiinflammatory, hypoglycemic, hepatoprotective, hypolipidemic, antibacterial and antifungal. The results of data analyses on the chemical, pharmacological and toxicological characteristics of T. polium support the view that this plant has beneficial therapeutic properties. However, further studies to identify the active components and further verify their relevant pharmacological activities are warranted.

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Section: Antioxidant Activitiesmentioning

confidence: 99%

Phytochemistry and Medicinal Properties of Teucrium polium L. (Lamiaceae)

Bahramikia

Yazdanparast

2012

Phytotherapy Research

Self Cite

116

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“…Homogenate was then centrifuged at 5000 g for 15 min at 4 o C. The protein concentration of the supernatant was determined by the total protein kit (Agappe diagnostics, India). Oxidative stress was induced as described previously [24] with a peroxyl radical inducer (AAPH). The reaction mixture was composed of liver homogenate (15 mg protein), 40 mm AAPH and a fixed concentration of various solvent extract of Tinospora stem and leaf (2 mg).…”

Section: Protective Effect On Biomolecule Oxidation Ex Vivomentioning

confidence: 99%

Antioxidant Potential of Tinospora cordifolia Extracts and their Protective Effect on Oxidation of Biomolecules

Nallamuthu¹,

Khanum²

2011

Pharmacognosy Journal

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a b s t r a c tTinospora cordifilia is a medicinal plant, commonly known as guduchi or amritha. in the present study, the antioxidant potential of solvent extracts of leaf and stem were evaluated by various in vitro methods. scavenging effects on DPPH, abts radical, hydroxyl radical and ferric reducing antioxidant power (FraP) were found to be highest in methanolic extract of leaf and ethyl acetate extract of stem compared to all other extracts. These extracts also exhibited significant protection against radical induced protein (bsa) oxidation and plasmid Dna damage (pbr322). the extracts were further evaluated for their inhibitory properties on aaPH (2, 2'-azo (2-amidinopropane) dihydrochloride induced ex vivo oxidative stress in rat liver homogenates. the results again showed the potent antioxidant nature of methanolic extract of leaf and ethyl acetate extract of stem with respect to inhibition of lipid and protein oxidation. overall, stem extracts showed to be the more effective antioxidant source than the leaf extracts with regard to all the radical scavenging activities. these protective properties of the extracts could be directly attributed to the presence of phytochemicals such as polyphenols, tannins etc. in conclusion, our results demonstrate the potential antioxidant activities of guduchi leaf as well as stem and therefore, it can be used as a source of antioxidant for health benefits through dietary supplementations.

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“…Phenolic acids and flavonoids have been reported to be the main phytochemicals responsible for the antioxidant capacity of fruits and vegetables. Plant derived polyphenols display characteristic inhibitory patterns toward the oxidative reaction in vitro and in vivo 35 .…”

Section: Resultsmentioning

confidence: 99%