Protective effects of Folic acid against reproductive, hematological, hepatic, and renal toxicity induced by Acetamiprid in male Albino rats

Toghan, Rana; Amin, Yahia A.; Ali, Rana A.; Fouad, Samer S.; Ahmed, Maha Abd-El Baky; Saleh, Shaimaa M. M.

doi:10.1016/j.tox.2022.153115

Cited by 24 publications

(16 citation statements)

References 54 publications

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“…This property has led to neonicotinoids becoming favored and popular insecticides worldwide over the past three decades [ 1 ]. Nevertheless, in recent years, neonicotinoids have been reported to have adverse effects on non-target organisms such as crustaceans, birds, fishes, and mammals [ 4 , 5 , 6 , 7 ]. For most neonicotinoids, due to their high solubility, they enter the freshwater environment easily in many ways, such as through rainfall, sewage and snowmelt [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Xie

2022

IJERPH

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As a major neonicotinoid insecticide, thiacloprid (THCP) is frequently detected in aquatic environments worldwide due to its heavy use, posing potential threats to aquatic organisms. In this study, zebrafish (Danio rerio) embryos were exposed to THCP (1, 10, 100, 1000 and 10,000 μg/L) for 5 days and then recovered in THCP-free water for 20 days to investigate the effects of early-stage THCP exposure on the development, antioxidant defense, and neurotransmitter systems of zebrafish, and explore their recovery mechanism. The results show that THCP exposure induced developmental toxicity and oxidative stress in zebrafish. The hypoactivity, behavioral alterations (decreased avoidance and edge preference behaviors) and neurotoxicity were found throughout the exposure-recovery experiments. THCP exposure altered the expression of γ-aminobutyric acid (GABA)- and serotonin (5-HT)-related genes accompanied by the decrease in GABA and 5-HT contents. However, after recovery, GABA content returned to the control level, but 5-HT did not, indicating that only the serotonergic system was persistently disrupted. Overall, our results suggest that the disruption of the serotonergic system and oxidative stress may aggravate neurotoxicity and that the former was the main reason for the depressive-like behavior. This study could help to unravel the mechanisms of the behavioral alterations induced by early-stage THCP exposure in zebrafish.

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Section: Introductionmentioning

confidence: 99%

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Xie

2022

IJERPH

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“… 64 Another study showed similar findings for rats dosed with 10 mg/kg body weight of acetamiprid for 5 weeks. 65 Female mice who were given acetamiprid in their diet for 28 days showed a dose-dependent increase in liver enzymes. 36 These findings could be related to a neonicotinoid-mediated increase in membrane permeability of hepatocytes, leading to a leakage of liver enzymes into the bloodstream.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are some toxicological studies that contradict the findings of the current study. 36 , 64 , 65 An experimental study in male Wistar rats treated with 45 mg/kg body weight of imidacloprid for 28 days showed significant increases in liver enzymes compared with controls. 64 Another study showed similar findings for rats dosed with 10 mg/kg body weight of acetamiprid for 5 weeks.…”

Section: Discussionmentioning

confidence: 99%

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

Godbole,

Chen,

Vuong

2024

Environmental Epidemiology

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Background: Toxicological studies indicate that neonicotinoids may be associated with disruptions in liver function due to an increase in oxidative stress. There are scant epidemiological studies investigating the chronic hepatotoxic effects of neonicotinoids. Objective: To examine the association between detectable concentrations of parent neonicotinoids and neonicotinoid metabolites with liver function markers among US adults, and whether sex modifies this association. Methods: National Health and Nutrition Examination Survey 2015–2016 data were used to estimate associations between detectable neonicotinoids and serum alkaline phosphatase (ALP), alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transaminase (GGT), albumin, total bilirubin, total protein, and Hepatic Steatosis Index (HSI) using multiple linear regression. Results: Detectable levels of N-desmethyl-acetamiprid were associated with a decrease in GGT (β = −3.54 unit/l; 95% confidence interval [CI] = −6.48, −0.61) and detectable levels of 5-hydroxy-imidacloprid were associated with a decrease in HSI (β = −1.11; 95% CI = −2.14, −0.07). Sex modified the association between any parent neonicotinoid and ALP (P int = 0.064) and the association between clothianidin and ALP (P int = 0.019), with a pattern of positive associations in males and inverse associations in females, though stratified associations did not reach statistical significance. Sex also modified the association between 5-hydroxy-imidacloprid and total protein (P int = 0.062), with a significant positive association in females (β = 0.14 g/dl; 95% CI = 0.03, 0.25) and a null association in males. Conclusion: Detectable concentrations of neonicotinoid metabolites were inversely associated with GGT and HSI in US adults. Evidence suggests neonicotinoids may influence liver function differently depending on sex. Future research is recommended to replicate the findings as the study was limited in its cross-sectional nature and inability to examine continuous neonicotinoid concentrations with liver function.

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“…Conversely, biotin deficiency can result in reproductive decline, skeletal dysplasia, stunted embryonic, and young child growth ( 63 ). Folic acid has been demonstrated to promote the formation of red blood cells and play important roles in protein synthesis, cell division, and growth ( 64 , 65 ). Folic acid deficiency can cause megaloblastic anemia and affect hemoglobin production and cell maturation in red blood cells ( 65 , 66 ).…”

Section: Discussionmentioning

confidence: 99%

“…Folic acid has been demonstrated to promote the formation of red blood cells and play important roles in protein synthesis, cell division, and growth ( 64 , 65 ). Folic acid deficiency can cause megaloblastic anemia and affect hemoglobin production and cell maturation in red blood cells ( 65 , 66 ). Currently, folic acid is widely used in animal husbandry due to various important physiological functions.…”

Section: Discussionmentioning

confidence: 99%

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

Wang

Lin

et al. 2023

Front. Vet. Sci.

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Probiotics have attracted attention due to their multiple health benefits to the host. Yaks inhabiting the Tibetan plateau exhibit excellent disease resistance and tolerance, which may be associated with their inner probiotics. Currently, research on probiotics mainly focuses on their positive effects on the host, but information regarding their genome remains unclear. To reveal the potential functional genes of Bacillus subtilis isolated from yaks, we sequenced its whole genome. Results indicated that the genomic length of Bacillus subtilis was 866,044,638 bp, with 4,429 coding genes. The genome of this bacteria was composed of one chromosome and one plasmid with lengths of 4,214,774 and 54,527 bp, respectively. Moreover, Bacillus subtilis contained 86 tRNAs, 27 rRNAs (9 16S_rRNA, 9 23S_rRNA, and 9 5S_rRNA), and 114 other ncRNA. KEGG annotation indicated that most genes in Bacillus subtilis were associated with biosynthesis of amino acids, carbon metabolism, purine metabolism, pyrimidine metabolism, and ABC transporters. GO annotation demonstrated that most genes in Bacillus subtilis were related to nucleic acid binding transcription factor activity, transporter activity, antioxidant activity, and biological adhesion. EggNOG uncovered that most genes in Bacillus subtilis were related to energy production and conversion, amino acid transport and metabolism, carbohydrate transport and metabolism. CAZy annotation found glycoside hydrolases (33.65%), glycosyl transferases (22.11%), polysaccharide lyases (3.84%), carbohydrate esterases (14.42%), auxiliary activities (3.36%), and carbohydrate-binding modules (22.59%). In conclusion, this study investigated the genome and genetic properties of Bacillus subtilis derived from yaks, which contributed to understanding the potential prebiotic mechanism of probiotics from the genetic perspective.

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Protective effects of Folic acid against reproductive, hematological, hepatic, and renal toxicity induced by Acetamiprid in male Albino rats

Cited by 24 publications

References 54 publications

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Early-Stage High-Concentration Thiacloprid Exposure Induced Persistent Behavioral Alterations in Zebrafish

Associations between neonicotinoids and liver function measures in US adults: National Health and Nutrition Examination Survey 2015–2016

Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics

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