Protective effects of flavonoids isolated from Agrocybe aegirita on dextran sodium sulfate‐induced colitis

Abstract

Mushroom derived phytochemical has become the promising agent to treat inflammatory bowel disease (IBD). Here, we investigated the effect of flavonoids from <i>Agrocybe aegirita</i> (AAF) on dextran sodium sulfate-induced colitis. Our results showed that flavonoids from <i>Agrocybe aegirita</i> had a certain effect on physical signs in mice (improving the weight loss of mice, reducing reducing the DAI index and the spleen index of mice). AAF could also significantly reduce the shortening of the colon, and improve the level of tissue damage and colon inflammation. Besides, AAF could alleviate the colon inflammatory status including reducing the levels of TNF-α and IL-1β and increasing the levels of IL-10. In addition, AAF significantly promoted the growth of goblet cells and enhance the intestinal barrier function (the secretion of mucin in the colon were increased). In conclusion, flavonoids from <i>Agrocybe aegirita</i> has the potential to relieve the DSS-induced colitis in mice and could be a novel therapy for combating with IBD.

The regulatory effect of total flavonoids of Sedum aizoon L. on oxidative stress in type 1 diabetic mice

“…The experimental factors and levels are shown in Table A.1 . The determination of total flavonoids was carried out according to existing methods ( Zhang et al, 2021 ).…”

Study on nutritional components evaluation and origin differences of Agrocybe cylindracea from different regions

“…Although more and more reports have been published in recent years, research on A. cylindracea in China was still mainly focused on cultivation (Benshou et al, 2018), bioactive substances (Kanno et al, 2021; Li et al, 2021; Zhang et al, 2021), and comparison with other edible mushrooms (Jacinto‐Azevedo et al, 2021). There are no reports of nutritional features of A. cylindracea associated with its strains and geographical features.…”

Guideline for the extraction, isolation, purification, and structural characterization of polysaccharides from natural resources

“…Polysaccharides are abundant biomacromolecules in nature and are widely found in plants, animals, and microorganisms (fungi and bacteria). In recent years, numerous studies had revealed that polysaccharides from natural sources had various bioactive functions, such as immunoregulation (Sun et al, 2021), regulation of gut microbiota (H. Lin, Zhang, et al, 2021), antitumor (Zhao et al, 2020), anti‐inflammatory (J. Zhang et al, 2021), blood sugar and lipid regulation (Y. Zhang et al, 2021), and so on. Its extraction and purification are the first and also one of the most critical parts of complex carbohydrate study.…”