Protective effects of exogenous secretin on ceruletide-induced acute pancreatitis in the rat.

Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

“…It was reported that cAMPstimulated pathway reduces cellular injury by causing secretion of active enzymes from pancreatic acinar cells (27). Furthermore, it was shown that exogenous secretin ameliorates acute pancreatitis in rats and dogs (28)(29)(30)(31). The apparent discrepancy with our study may be related to the time course of cAMP in- tracellular levels and a possible dual role of the second messenger.…”

Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.

“…Secretin had been proposed to be protective against caeruleininduced acute pancreatitis in rats and dogs (2,3). Subsequent studies in the caerulein model in mice (1,18) and in a model employing injections ofbile salts into the pancreatic duct ofrats (19, 20) did not show any major beneficial effect of secretin.…”

“…Secretin had previously been proposed to have major beneficial effects on caeruleininduced pancreatitis in rats (2) and in dogs (3). The recently developed serine protease inhibitor gabexate mesilate also had protective effects against acute experimental pancreatitis in rats (4).…”

Pathophysiological relevance of apical large-conductance Ca2+-activated potassium channels in pancreatic duct epithelial cells

“…Theoretically, the increased volume secretion helps to wash out the toxic factors (such as bile acids or activated enzymes) from the pancreas, whereas, the secretory block during the onset of pancreatitis would exacerbate the severity of inflammatory disease. The beneficial effect of this fluid hypersecretion is further supported by those studies in which secretin, one of the major secretagogues of ductal fluid secretion, was shown to reduce the severity of caerulein-induced acute pancreatitis 17 18. Moreover, others have found that secretin has a small beneficial effect on the histological alterations in experimental acute pancreatitis induced by caerulein stimulation 19 20.…”