Protective effects of Eucommia lignans against hypertensive renal injury by inhibiting expression of aldose reductase

Li, Ling; Yan, Jin; Hu, Keqi; Gu, Juan; Wang, Junjie; Deng, Xiaolan; Li, Hui; Xian, Jing; Li, Zhenyu; Ye, Qifa; Ouyang, Dongsheng

doi:10.1016/j.jep.2011.11.032

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…Our results indicated that both FER and ZOP significantly reduced the elevations in diastolic BP associated with MetS. The effect of FER is explained by its AR inhibition, which is consistent with previous studies that reported that AR inhibition protects against development of hypertension in spontaneously hypertensive rat [26] and diabetic rat [27] models.…”

Section: Discussionsupporting

confidence: 92%

Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

El-Bassossy

Badawy

Neamatallah

et al. 2016

Chemico-Biological Interactions

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Section: Discussionsupporting

confidence: 92%

Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

El-Bassossy

Badawy

Neamatallah

et al. 2016

Chemico-Biological Interactions

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“…Eucommia extract was shown to possess antioxidative effect [12, 13], hypoglycemic and hypolipidemic effects [14, 15], and antihypertensive effect [16, 17]. Lignans, the major bioactive compounds of Eucommia , was shown to inhibit hypertensive renal injury [18] and angiotensin II induced proliferation [19, 20] and extracellular matrix production [20] in rat mesangial cells. This study aimed to investigate whether PD has protective effects against oxLDL-induced endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Pinoresinol Diglucoside Alleviates oxLDL‐Induced Dysfunction in Human Umbilical Vein Endothelial Cells

Yao

Zou

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Atherosclerotic cardiovascular diseases are the leading causes of morbidity and mortality worldwide. Deposition of oxidized low-density lipoprotein (oxLDL) is one of the initiators and promoters of atherosclerosis. Eucommia lignans were shown to possess antihypertensive effects. This study aimed to investigate the effects of pinoresinol diglucoside (PD), a Eucommia lignan, on oxLDL-induced endothelial dysfunction. HUVECs were treated with oxLDL and/or PD followed by assessing radical oxygen species (ROS), apoptosis, nitrogen oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) activity with specific assays kits, mRNA levels with quantitative real-time polymerase chain reaction (PCR), and protein levels with western blot. PD abolished oxLDL-induced ROS and MDA production, apoptosis, upregulation of lectin-like oxidized LDL recptor-1 (LOX-1), intercellular Adhesion Molecule 1 (ICAM-1), and nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), and activation of p38MAPK (mitogen-activated protein kinases)/NF-κB signaling. Meanwhile, PD alleviated oxLDL-caused inhibition of SOD activity, eNOS expression, and NO production. These data demonstrated that PD was effective in protecting endothelial cells from oxLDL-caused injuries, which guarantees further investigation on the clinical benefits of PD on cardiovascular diseases.

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“…We previously confirmed that lignans were the effective fraction of Du-zhong for antihypertension [10,19]. Further study showed that both N-acetyl-β-D-glucosaminidase enzyme activity and the ratio of albumin to urinary creatinine decreased in spontaneous hypertensive rat (SHR)-treated with Eucommia lignans [12]. Eucommia lignans also inhibited the expression of collagen type III (Col III) in the glomerular basement membrane, and diminished the over-expression of AR in the kidney [11].…”

Section: Introductionmentioning

confidence: 90%

“…AR can be activated by TGF-β1, oxidative stress and inflammation [9-12], to stimulate proliferation of MCs and deposition of ECM induced by TGF-β1 and PDGF [13-16]. An over-expression of AR was observed in the renal tissue of spontaneous hypertensive rats (SHR) in our previous study [12]. AR might be involved in the pathological process induced by Ang II in MCs.…”

Section: Introductionmentioning

confidence: 99%

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Lignans from the bark of Eucommia ulmoides inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells

Deng

Huang

et al. 2014

Chin Med

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BackgroundTree bark of Eucommia ulmoides Oliv., (commonly well-known as “Du-zhong” in China), has been used to treat hypertension, hypercholesterolemia, hyperglycemia, hepatic fibrosis and renal injury. This study aims to investigate the effects of lignans extracted from the bark of Eucommia ulmoides Oliv. on Ang II-induced proliferation and extracellular matrix biosynthesis in rat mesangial cells.MethodsRat mesangial cells (RMCs) were cultured in vitro and divided into six groups (control, Ang II, losartan, and low, middle and high concentration lignans groups). RMC proliferation was measured by MTT assay. RT-qPCR and western blotting were used to detect mRNA and protein expression of collagen type I (Col I), collagen type III (Col III), collagen type IV (Col IV), fibronectin and aldose reductase (AR).ResultsCellular proliferation induced by Ang II was significantly suppressed by Eucommia lignans of different concentrations (P = 0.034, P < 0.001, and P < 0.001). Treatment of cells with Ang II increased Col I, Col III, Col IV, and fibronectin mRNA expression, which was observed at the protein level (P < 0.001, P < 0.001, P = 0.004, and P = 0.004, respectively). The increased mRNA expression and protein levels of Col I, Col III, Col IV, and fibronectin were diminished remarkably with by treatment Eucommia lignans, and elevated AR expression stimulated by Ang II was significantly inhibited by Eucommia lignans.ConclusionsEucommia lignans (Du-zhong) inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells.

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Protective effects of Eucommia lignans against hypertensive renal injury by inhibiting expression of aldose reductase

Cited by 26 publications

References 19 publications

Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

Pinoresinol Diglucoside Alleviates oxLDL‐Induced Dysfunction in Human Umbilical Vein Endothelial Cells

Lignans from the bark of Eucommia ulmoides inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells

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