Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway

Yang, Hong; Gan, Shiquan; Jiang, Zhaohui; Song, Xiaomei; Chen, Tingting; Xu, Yini; Fu, Lingyun; Zhang, Yanyan; Tao, Ling; Shen, Xiangchun

doi:10.1186/s13020-019-0283-4

Cited by 12 publications

(4 citation statements)

References 28 publications

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“…DR is a common complication of diabetes that leads to extensive retinal damage. 29 However, the detailed molecular mechanisms are not fully understood. High-throughput RNA-Seq and bioinformatics are formidable tools for analyzing the molecular events underlying phenotypic alterations.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina

Ye,

Wang,

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose Diabetic retinopathy (DR) is a common complication of diabetes and has a high prevalence. Dysregulation of circadian rhythmicity is associated with the development of DR. This research aimed to investigate rhythmical transcriptome alterations in the retina of diabetic mice. Methods C57BL/6J mice were used to establish a diabetes model by intraperitoneal injection of streptozotocin (STZ). After 12 weeks, retinas were collected continuously at 4-hour intervals over 1 day. Total RNA was extracted from normal and STZ-treated retinas and RNA sequencing was performed. Meta2d algorithm, Kyoto Encyclopedia of Genes, Phase Set Enrichment Analysis, and time-series cluster analysis were used to identify, analyze and annotate the composition, phase, and molecular functions of rhythmic transcripts in retinas. Results The retina exhibited powerful transcriptome rhythmicity. STZ-induced diabetes markedly modified the transcriptome characteristics of the circadian transcriptome in the retina, including composition, phase, and amplitude. Moreover, the diabetic mice led to re-organized temporal and clustering enrichment pathways in space and time and affected core clock machinery. Conclusions Diabetes impairs the circadian rhythm of the transcriptomic profile of retinas. This study offers new perspectives on the negative effects of diabetes on the retina, which may provide important information for the development of new treatments for DR.

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Section: Discussionmentioning

confidence: 99%

Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina

Ye,

Wang,

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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“…VEGF and GFAP are responsible for initiating retinal glia gliosis and angiogenesis and leading to diabetic retinopathy. PPAR-γ inhibits CaMK II/CREB pathway following oil of Fructus Alpiniae zerumbet treatment, leading to cure diabetes retinopathy in animal model (Yang et al 2020a). Hyperglycemia initiates the pro-inflammatory cytokine VEGF via activation of the CaMKII/NF-κB pathway.…”

Section: Camkii Performs Osteoclast Diabetic Retinopathy Stomach Cell...mentioning

confidence: 99%

The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression

Benchoula

Mediani

Wong

2022

J. Cell Commun. Signal.

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The increase in blood glucose causes a myriad of pathways and molecular components to malfunction, leading to diabetes. Diabetes affects each organ differently by activating distinct pathways. It has an impact on the liver, pancreas, kidney (nephropathy), eyes (retinopathy), and nervous system (neuropathy). Understanding the effects of diabetes on each organ is the first step in developing a sustained treatment for the disease. Among the many cellular molecules impacted by diabetes is Ca 2+ /calmodulin-dependent protein kinase II (CaMKII), a complex Ca 2+ /calmodulin-activated serine/threonine-protein kinase. When intracellular [Ca 2+ ] rises, it binds to calmodulin (CaM) to produce Ca 2+ /CaM, which activates CaMKIIs. This factor is involved in the pancreas, liver, heart, muscles, and various organs. Thus, Understanding CaMKII action in each organ is critical for gaining a complete picture of diabetic complications. Therefore, this review covers CaMKII's functions in many organs and how it affects and has been affected by diabetes.

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“…Microvascular complications of diabetic mellitus (DM) include diabetic retinopathy (DR) [1]. The prevalence of DR in DM patients is about 1/3, and 1/10 of them have a threat to normal visual status [2].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-425-5p Is Involved in the Development of Diabetic Retinopathy and Regulates the Proliferation and Migration of Retinal Microvascular Endothelial Cells

et al. 2021

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Introduction: The objective of this article was to detect the expression pattern and clinical value of miR-425-5p in diabetic retinopathy (DR) patients and investigate its effect on the proliferation and migration of human retinal microvascular endothelial cells (HRMECs) in a high glucose (HG) state. Methods: The serum miR-425-5p level of the subjects was determined using quantitative real-time PCR. The diagnostic value of serum miR-425-5p was validated using the receiver operating characteristic curve. Pearson analysis detected the correlation between clinical indicators and microRNA. The influence of miR-425-5p on cell proliferation and migration under HG conditions was calculated by using Cell Counting Kit-8 and Transwell assay. Results: Serum miR-425-5p levels showed a gradual increasing trend in the healthy control group, the diabetic mellitus patients without DR, and DR patients. Moreover, the levels of miR-425-5p in proliferative DR (PDR) patients were elevated than that of non-PDR (NPDR) patients. Furthermore, upregulated miR-425-5p had a high diagnostic value for DR patients and can distinguish PDR patients from NPDR patients. The expression of miR-425-5p was significantly positively correlated with the fasting plasma glucose, glycosylated hemoglobin (HbA1C), homeostasis model assessment of insulin resistance, and disease course of the patients. Under HG conditions, overexpression of miR-425-5p promoted HRMEC proliferation and migration, while inhibition of miR-425-5p led to opposite results. Conclusion: Present research confirmed that serum miR-425-5p levels in DR are marked by elevation. High expression of miR-425-5p can be used as a feasible diagnostic biomarker for DR patients and can predict the development and severity of DR. Moreover, inhibiting the expression of miR-425-5p levels under the condition of hyperglycemia may be used as a valuable therapeutic strategy for preventing the pathogenesis of DR.

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Protective effects of essential oil from Fructus Alpiniae zerumbet on retinal Müller gliosis via the PPAR-γ-p-CREB signaling pathway

Cited by 12 publications

References 28 publications

Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina

Diabetes Reshapes the Circadian Transcriptome Profile in Murine Retina

The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression

MicroRNA-425-5p Is Involved in the Development of Diabetic Retinopathy and Regulates the Proliferation and Migration of Retinal Microvascular Endothelial Cells

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