Protective effects of erythropoietin on ischemia/reperfusion injury of rat ovary

Karaca, Mehmet; Odabaşoğlu, Fehmi; Kumtepe, Yakup; Albayrak, Abdulmecit; Çadırcı, Elif; Keleş, Osman Nuri

doi:10.1016/j.ejogrb.2009.03.011

Cited by 41 publications

(37 citation statements)

References 27 publications

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“…Hypoxia generally impairs intracellular Ca +2 homeostasis and leads to various pathological situations such as neuronal cell damage, neurodegeneration, and cell death. The damage that occurs varies as a function of the duration of hypoxia as a result of ischemia according to fetal age [14][15][16]. We demonstrated that the survivals rates of infant rats born to rats with torsio/detorsio uteri were decreased.…”

Section: Metagenomic Sequencingmentioning

confidence: 83%

Clinical and Pathological Changes in the Offspring of Rats with Torsio Uteri

Rişvanlı¹,

Timurkaan²,

Saat³

et al. 2017

Journal of Veterinary Science and Animal Husbandry

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Section: Metagenomic Sequencingmentioning

confidence: 83%

Clinical and Pathological Changes in the Offspring of Rats with Torsio Uteri

Rişvanlı¹,

Timurkaan²,

Saat³

et al. 2017

Journal of Veterinary Science and Animal Husbandry

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“…One of the major obstacles of ovary transplantation appears to be ischemia/reperfusion (IR) injury occurring during the time period required for the revascularization of the transplanted tissue, which consequently leads to cytokine and free radical release, platelet activation, and apoptosis (Demeestere et al 2009, Hemadi et al 2009, Karaca et al 2009, Commin et al 2012, causing massive primordial follicle loss and shorter lifespan of the transplanted ovary (Demeestere et al 2009, Soleimani et al 2011. Therefore, the application of any approach to minimize ischemic injury during the initial post-transplantation period and establishment of angiogenesis in the ovarian grafts such as the choice of the transplantation site (Israely et al 2003, 2006, Soleimani et al 2008, the use of antioxidants (Nugent et al 1998, Sapmaz et al 2003, Sayyah-Melli et al 2011, angiogenic factors (Commin et al 2012), and hormonal factors (Yang et al 2008, Wang et al 2012 can play an important role in the success of ovarian tissue transplantation (Suzuki et al 2008, Yang et al 2008.…”

Section: Introductionmentioning

confidence: 99%

“…Erythropoietin (EPO) is a hematopoietic cytokine (Karaca et al 2009, Hamed et al 2010, Commin et al 2012) that is known for its antioxidant, antiapoptotic, and anti-inflammatory properties through the promotion of cell survival signaling cascades (Karaca et al 2009), upregulation of the expression of antiapoptotic proteins, modulation of the intracellular calcium metabolism, attenuation of NO production, and inhibition of glutamate release (Karaca et al 2009, Commin et al 2012. EPO also stimulates angiogenesis indirectly in the ischemic tissue by increasing the expression of VEGFA and recruiting endothelial progenitor cells (Hamed et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Experimental studies have revealed that EPO has protective effects against IR injury in organs expressing the EPO receptor (Yasuda et al 2001, Sayyah-Melli et al 2011 such as the liver, lung, myocardium, retinal neurons, spinal cord, and kidney (Junk et al 2002, Karaca et al 2009. Recently, some studies have reported the antioxidative and protective effects of EPO on the IR injury of ovary (Bakan et al 2009, Karaca et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Effects of erythropoietin on ischemia, follicular survival, and ovarian function in ovarian grafts

Mahmoodi¹,

Mehranjani²,

Shariatzadeh³

et al. 2014

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Ovarian tissue transplantation is performed to preserve fertility in patients undergoing chemotherapy and radiotherapy. However, ischemia/reperfusion (IR) injury and free radical production occurring during the revascularization of the transplanted tissue are the major limitations of this procedure. The aim of this study was to investigate the effect of erythropoietin (EPO) as an antioxidant on oxidative stress and ovary survival following transplantation. The Naval Medical Research Institute (NMRI) mice (4-5 weeks old) were divided into three groups (six mice per group): control; autograftCsaline, and autograftCEPO (500 IU/kg i.p.). After 28 days, ovary compartments were estimated stereologically. DNA fragmentation and plasma malondialdehyde (MDA), progesterone, and estradiol (E 2 ) concentrations were also evaluated. The results were analyzed using one-way ANOVA and Tukey's test, and the means were significantly different at P!0.05. The mean total volume of ovary, cortex, and medulla and the number of follicles increased significantly in the autograftCEPO group (P!0.01). Apoptosis rate in the autograftCEPO group was lower than that in the autograftCsaline group. The concentration of MDA decreased significantly in the autografted EPO-treated group than in the autografted saline-treated group (P!0.01). The concentration of E 2 increased significantly in the autograftCEPO group than in the autograftCsaline group (P!0.01). EPO reduced IR injury, increasing follicle survival and function in grafted ovaries. Free Persian abstractA Persian (Farsi) translation of the abstract is freely available online at

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“…All studies used a characteristic substance tissue as the functional index of IR. The dose [2] of the molecule of Epo was 5,000 IU/kg. The aim of the present experimental study was the trial of Epo on a rat animal model and in a renal IR protocol.…”

Section: Introductionmentioning

confidence: 99%

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

Tsompos¹,

Panoulis

Toutouzas³

et al. 2014

Turkish Journal of Urology

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Objective: The aim of this experimental study was to assess the effect of erythropoietin on a rat model, particularly under a renal ischemia reperfusion protocol. The beneficial or lack of effects of that molecule on the excreted renal product of serum uric acid were studied biochemically. Material and methods:Forty rats were used with a mean weight of 247.7 gr. Serum uric acid levels were measured measured at 60 min after reperfusion (Groups A and C) and at 120 min after reperfusion (groups B and D). Conclusion:Erythropoietin administration, reperfusion time and their interaction have no significant shortterm alterations on serum uric acid levels. Conclusions cannot be extracted by non-significant p-values within 2 hours. Obviously, longer study times may permit safer results.

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Protective effects of erythropoietin on ischemia/reperfusion injury of rat ovary

Cited by 41 publications

References 27 publications

Clinical and Pathological Changes in the Offspring of Rats with Torsio Uteri

Clinical and Pathological Changes in the Offspring of Rats with Torsio Uteri

Effects of erythropoietin on ischemia, follicular survival, and ovarian function in ovarian grafts

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

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