Protective Effects of Embelin and Curcumin against Diethylnitrosamine / Phenobarbital induced Experimental Hepatocarcinogenesis in Rats

Jagadeesh, MC; Sreepriya, M.; Bali, Geetha; Manjulakumari, D

doi:10.3126/ijls.v5i1.5576

Cited by 6 publications

(4 citation statements)

References 14 publications

(6 reference statements)

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“…A methanol extract of E. ribes fruits showed protective effect against multi-mutagenicity and genotoxicity, induced by cyclophosphamide in mice, as multi-mutagenicty is considered as a molecular basis of cancer 52 . E. ribes contains embelin, quercitol (polyphenols), flavonoids, tannins, saponins and alkaloid 53,54 . Embelin (EB), a phenolic compound, is protective against diethylnitrosamine/phenobarbital induced hepatocarcinogenesis in rat 55 .…”

Section: Embelia Ribes Burm F: Embelia Ribesmentioning

confidence: 99%

Anti-cancer potential of South Asian plants

Rahman

2013

Nat. Prod. Bioprospect.

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Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability, potential anti-cancer activity with less adverse effects when compared with chemotherapy. The variation of climate and geography in South Asian countries provides a nursing environment for the growth of versatile plant species, that are repeatedly drawing attention of the scientific community. In this review, we have focused on the anti-cancer potential of thirty plants, which are commonly found in Bangladesh, India, Nepal, Pakistan and Sri Lanka, with their mechanisms of action. In particular, we have discussed the bio-active components that display anti-cancer activity, which have been identified in these plants. This review may help researchers to profile plants with known anti-cancer effect of this region and further investigations of anti-cancer agents in medicinal plants from South Asia.

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Section: Embelia Ribes Burm F: Embelia Ribesmentioning

confidence: 99%

Anti-cancer potential of South Asian plants

Rahman

2013

Nat. Prod. Bioprospect.

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“…The occurrence of lesions on surface of liver grossly and formation of preneoplastic altered hepatic foci in liver of DEN treated rats by 30 th day was considered as mainly due to the DNA damage through oxidative stress caused by DEN which causes perturbations in the nuclear enzymes involved in DNA repair/replication (Jagadeesh et al, 2011) [7] . The glycogen positivity in the clear cell foci is attributable to the alteration in glucose metabolism caused by DEN in those cells.…”

Section: Discussionmentioning

confidence: 99%

Anti-preneoplastic and anti-fibrogenetic effect of zinc oxide nanoparticles (ZnO NPs) against experimental hepatocarcinogenesis

K¹,

Rao²,

Satyanarayana³

et al. 2020

Int. J. Chem. Stud.

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To investigate the effects of zinc oxide nanoparticles (ZnO NPs) against hepatocarcinogenesis, the present study was conducted. To induce hepatocarcinogenesis rats with Diethylnitrosamine (DEN) at 100 mg/kg body weight intraperitoneally on Day 1 followed by 0.01 % DEN in drinking water ad libitum for 60 days. Zinc oxide nanoparticles as aqueous suspension was gavaged orally at a dose rate of 25 mg/kg body weight for 15 days prior to DEN treatment in ZnO NPs pre-treatment group and concurrently with DEN for 60 days in ZnO NPs concurrent treatment group. DEN induced severe hepatic damage and formation of preneoplastic altered hepatic foci by 30 th day and severe fibrotic tissue proliferation with development of hepatic adenoma and carcinoma by 60 th day. In pre-treatment and concurrent treatment groups, ZnO NPs reduced the extent of hepatic damage, prevented the formation of altered hepatic foci by 30 th day and drastically reduced the extent of fibrotic tissue proliferation by 60 th day which were determined through routine histopathology of hepatic tissue and special staining techniques alongside gross observation of liver.

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“…2,3 In human consumption of DEN leads to conversion of free radicals by CYP450 dependent oxygenase forms alkyl DNA adducts and mutates the liver resulting in formation of liver cancer. 4,5 Among the HCC model, DEN-induced HCC was most widely accepted model for the screening of chemo-preventive and chemotherapeutic potential of test drugs. As chemo-protective effect is evidenced in phytochemicals such as, vincristine, paclitaxel, etoposide, teniposide, irinotecan and topotecan, it is also further evident as literature review suggests the daily diets of flavonoids (triterpenoids) reduce the cancer occurrence substantially.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chemo-Preventive Effect of Methanolic Fruit Extract of Cucumis melo var. agrestis on DEN-Induced HCC in Sprague Dawley Rats

Sivakumar¹,

Devi²

2023

Ind. J. Pharm. Edu. Res

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Aim: To investigate chemo-preventive effect of methanolic fruit extract of Cucumis melo var. agrestis on DEN (diethyl-nitrosamine) induced hepatocellular carcinoma in Sprague Dawley rats. Materials and Methods: Five groups of rats randomly selected comprising of 6 animals on each group, all groups, except Group-1 were administered single dose of DEN (200 mg/kg, i.p. dissolved in PBS) for the induction of HCC and promoted by phenobarbital (0.05%) for 16 weeks. Group-I was administered only normal saline, however Group-3, 4 and were intervened by the standard (5-FU) and Test-1 and 2 by MECM. At the end of 16 th week, overnight fasted rats were sacrificed under anaesthesia then blood samples and liver were collected to analyse morphological liver, to evaluate serum antioxidant, liver enzymatic, non-enzymatic, haematological parameters as well as to evaluate histopathology to assess the effect of standard (5-FU) as well as test (MECM) on DEN induced HCC in rats. Results: As in the case of Test-1 and 2 groups treated by low and high dose (200 mg/kg and 400 mg/kg) of MECM has showed only mild to moderate dose dependant effect on serum anti-oxidant as well as liver enzymatic and non-enzymatic activity. However, other parameter such as in body weight, liver morphology, tumour incidence, haematological as well as histopathology results with respect to standard drug (5-FU) was very poor. Conclusion:This study has demonstrated that MECM clearly lack its ability to act as a chemo-preventive agent, however the moderate antioxidant effect might place it as an effective adjuvant on the treatment of HCC.

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Protective Effects of Embelin and Curcumin against Diethylnitrosamine / Phenobarbital induced Experimental Hepatocarcinogenesis in Rats

Cited by 6 publications

References 14 publications

Anti-cancer potential of South Asian plants

Anti-cancer potential of South Asian plants

Anti-preneoplastic and anti-fibrogenetic effect of zinc oxide nanoparticles (ZnO NPs) against experimental hepatocarcinogenesis

Evaluation of Chemo-Preventive Effect of Methanolic Fruit Extract of Cucumis melo var. agrestis on DEN-Induced HCC in Sprague Dawley Rats

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