Protective Effects of Ellagic Acid against UVA-induced Oxidative Stress in Human Dermal Papilla

Abstract

MSCs have become an emerging cell source with their immune modulation, high proliferation rate, and differentiation potential; indeed, they have been challenged in clinical trials. Recently, it has shown that ROS play a dual role as both deleterious and beneficial species depending on their concentration in MSCs. Various environmental stresses-induced excessive production of ROS triggers cellular senescence and abnormal differentiation on MSCs. Moreover, MSCs have been suggested to participate in the treatment of ALI/ARDS and COPD as a major cause of high morbidity and mortality. Therapeutic mechanisms of MSCs in the treatment of ARDS/COPD were focused on cell engraftment and paracrine action. However, ROS-mediated therapeutic mechanisms of MSCs still remain largely unknown. Here, we review the key factors associated with cell cycle and chromatin remodeling to accelerate or delay the MSC aging process. In addition, the enhanced ROS production and its associated pathophysiological pathways will be discussed along with the MSC senescence process. Furthermore, the present review highlights how the excessive amount of ROS-mediated oxidative stress might interfere with homeostasis of lungs and residual lung cells in the pathogenesis of ALI/ARDS and COPD.

Assessment of validation and antioxidant activities of novel 12 Korean strawberry cultivars

“…There were significant (p < 0.05) differences in ABTS free radical scavenging activity among strawberry cultivars. Kim et al (2016) have reported that ABTS free radical scavenging activities of raspberry and blackberry are 72 μmol TE/g and 20 μmol TE/g, respectively, lower than ours. Lee et al (2015) have reported that ABTS free radical scavenging activities of black raspberry, blueberry, and raspberry are 2.99 mmol TEAC/100 g FW, 1.47 mmol TEAC/100 g FW, and 0.77 mmol TEAC/100 g FW, respectively.…”

“…It can also protect cells against apoptosis (Xu et al, 2003). Ellagic acid may produce positive effects in the control of estrogen receptor, collagen expression, and inhibition of photoresistance damage in fibroblasts (Kim et al, 2016;Türk et al, 2010;Papoutsi et al, 2005). In addition, ellagic acid can prevent tissue damage by repress peroxide lipid formation and control carcinogenesis by promoting the activity of detoxification enzyme (Maas et al, 1991).…”

Photodamage attenuation effect by angelic acid in UVA irradiation-induced damages in normal human dermal fibroblast

“…Three types of UV rays, UVA (315-400 nm), UVB (280-315 nm), and UVC (200-280 nm), compose solar radiation and only UVA and UVB inflict damage to ground surface because UVC is screened out by the ozone layer (Ko, 2015). The deepest penetration is from UVA; even relative intensity is not more energetic than UVB, which can reach deeper skin layers (Binic et al, 2013;Kim et al, 2016;Song et al, 2016). Increased substantial ROS by UV irradiation in the cells augment proteins that deplete ECM components (Binic et al, 2013;Song et al, 2016;Rittié & Fisher, 2002;Tsuji et al, 2001).…”