1992
DOI: 10.1016/0014-2999(92)90286-d
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Protective effects of E3330, a novel quinone derivative, on galactosamine/tumor necrosis factor-α-induced hepatitis in mice

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Cited by 21 publications
(12 citation statements)
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“…It induces hepatitis by hindering the synthesis of RNA and protein via reduction in cellular UTP uptake that tips to the hepatic parenchyma necrosis [6, 7]. The quinones, flavones and carotenoids are well known antioxidants that are claimed to be hepatoprotective were evaluated by D-GaLN/LPS hepatic damage model [8, 9]. …”
Section: Introductionmentioning
confidence: 99%
“…It induces hepatitis by hindering the synthesis of RNA and protein via reduction in cellular UTP uptake that tips to the hepatic parenchyma necrosis [6, 7]. The quinones, flavones and carotenoids are well known antioxidants that are claimed to be hepatoprotective were evaluated by D-GaLN/LPS hepatic damage model [8, 9]. …”
Section: Introductionmentioning
confidence: 99%
“…Phenolic antioxidants exhibit anti-inflammatory, anticarcinogenic, and antidiabetic activities in animals (Wattenberg et al, 1980;Talalay et al, 1988;Bjorkhem et al, 1991;Nagakawa et al, 1993;Futakuchi et al, 1998;Nishizono et al, 2000). Human beings consume appreciable amounts of the antioxidants from dietary sources, either as natural components or as synthetic food additives (Nunn, 1991;Yang et al, 2001).…”
mentioning
confidence: 99%
“…This supports our hypothesis that the redox role is independent of the APE1 DNA repair function. The APE1 redox inhibitor, BQP, was initially identified as a small molecule that inhibited TNF-α production in vivo [32,54] using hepatitis models and LPS-stimulated macrophages including mononuclear cells and Kupffer cells. TNF-α is known to induce apoptosis in neurodegenerative diseases [55].…”
Section: Discussionmentioning
confidence: 99%