Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review

Zwolak, Iwona

doi:10.1155/2020/1490316

Cited by 49 publications

(36 citation statements)

References 122 publications

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“…E (100 mg/kg diet) against DNA damage in rats with CuO nanoparticles toxicity (250 mg/kg diet). Our outcomes are in settlement with a new study reporting potential anticipatory effects of dietary antioxidants, including vitamin E, ascorbic acid, phytosterols, polyphenols, and medicinal plants extracts against vanadium-induced DNA damage [ 103 ]. Another study showed that curcumin supplementation reduced genomic and cellular DNA damage in mice exposed to 390 ppm Cu [ 91 ].…”

Section: Discussionmentioning

confidence: 80%

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Hashem

Hamied

Ahmed

et al. 2021

Animals

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This experiment was carried out to explore the efficiency of an individual or combined doses of vitamin C (Vit. C) and vitamin E (Vit. E) in alleviating biochemical, genotoxicity, and pathological changes in the liver induced by copper sulfate (CuSO4) toxicity in broiler chickens. Two hundred and fifty-one-day-old broiler chicks were haphazardly allotted into five groups (five replicates/group, ten chicks/replicate). The birds were fed five experimental diets; (1) basal diet with no additives (CON), (2) basal diets supplemented with 300 mg CuSO4/kg diet (CuSO4), (3) basal diets supplemented with 300 mg CuSO4/kg diet + 250 mg Vit. C /kg diet, (4) basal diets supplemented with 300 mg CuSO4/kg diet +250 mg Vit. E /kg diet, (5) basal diets supplemented with 300 mg CuSO4/kg diet + 250 mg Vit. C /kg diet + 250 mg Vit. E /kg diet for six weeks. The results displayed that CuSO4-intoxicated birds had significantly (p < 0.05) decreased bodyweight, weight gain, and feed intake with increased feed conversion ratio from the 2nd week till the 6th week compared with the CON. However, these changes were minimized by single or combined supplementation of vitamin C and E. The FCR was insignificantly different in birds-fed diets complemented with vitamin C and E singly or in combination from the 3rd week of age compared to the CON. Serum aminotransferases (ALT, AST) and alkaline phosphatase (ALP) were elevated in CuSO4-intoxicated birds (p < 0.05). Additionally, they showed a drop in serum total protein (TP), albumin, globulins, triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C), and high-density lipoprotein-cholesterol (HDL-C) levels compared to the CON (p < 0.05). Concomitantly, histopathological and DNA changes were perceived in the liver of CuSO4-intoxicated birds. Co-supplementation of Vit. C and Vit. E single-handedly or combined with CuSO4-intoxicated chickens enhanced the performance traits and abovementioned changes, especially with those given combinations of vitamins. From the extant inquiry, it could be established that supplementation of vitamin C and E was beneficial for mitigating the harmful effects of CuSO4 toxicity on growth performance and liver histoarchitecture in broiler chickens.

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Section: Discussionmentioning

confidence: 80%

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Hashem

Hamied

Ahmed

et al. 2021

Animals

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“…As previously discussed in plasma LH concentrations, V has been reported to increase ROS generation in the body, which would induce oxidative stress, and could reduce testicular T synthesis [ 42 ]. Recently, Zwolak [ 55 ] reported the positive role of several dietary antioxidants in vanadium toxicology.…”

Section: Discussionmentioning

confidence: 99%

Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners

Alvés

Barrientos

Toro

et al. 2020

IJERPH

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Several essential trace minerals play an important role in the endocrine system; however, toxic trace minerals have a disruptive effect. The aim of this research was to determine basal concentrations and the possible correlations between trace minerals in plasma and several plasma hormones in runners. Sixty high-level male endurance runners (21 ± 3 years; 1.77 ± 0.05 m; 64.97 ± 7.36 kg) participated in the present study. Plasma hormones were analyzed using an enzyme-linked immunosorbent assay (ELISA) and plasma trace minerals were analyzed with inductively coupled plasma mass spectrometry (ICP-MS). Correlations and simple linear regression were used to assess the association between trace minerals and hormones. Plasma testosterone concentrations were inversely correlated with manganese (r = −0.543; β = −0.410; p < 0.01), selenium (r = −0.292; β = −0.024; p < 0.05), vanadium (r = −0.406; β = −1.278; p < 0.01), arsenic (r = −0.336; β = −0.142; p < 0.05), and lead (r = −0.385; β = −0.418; p < 0.01). Plasma luteinizing hormone (LH) levels were positively correlated with arsenic (r = 0.298; β = 0.327; p < 0.05) and cesium (r = 0.305; β = 2.272; p < 0.05), and negatively correlated with vanadium (r = −0.303; β = −2.467; p < 0.05). Moreover, cortisol concentrations showed significant positive correlations with cadmium (r = 0.291; β = 209.01; p < 0.05). Finally, insulin concentrations were inversely related to vanadium (r = −0.359; β = −3.982; p < 0.05). In conclusion, endurance runners living in areas with high environmental levels of toxic minerals should check their concentrations of anabolic hormones.

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“…It would prevent diabetes, has antiviral, antibacterial, and antiparasitic properties (Al-fartusie & Mohssan, 2017). At higher doses, harmful effects on the reproductive system and nephrotoxicity are reported, but natural antioxidants can play a role in reducing this toxicity (Zwolak, 2020). In Dialium guineense, levels of total polyphenols of 579 ± 6.013 mg EGA / 100g and total flavonoids: 19.45 ± 3.18 mg EQ / 100 g has been reported (Ayessou et al, 2014) in leaves.Therefore, it has lower polyphenol values than D. angolense.Tannins are reported to be anti-nutritional factors (S. .…”

Section: Nutritional Valuesmentioning

confidence: 99%

Potential Nutrition of Leaves and Fruits of Dialium Angolense Welw. Ex Oliv. (Fabaceae) an Antimalarial Plant From the Eastern of DR Congo

Valentin¹,

Salvius²,

Philippe³

et al. 2020

IJAR

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Dialium angolense were investigated to assess to the nutritive potentiality of his leaves and fruits and their implication in curative management of malaria using Standard analytical methods. The analysis showed that the carbohydrates, proteins, lipids, macro, micronutrients, and energy in fruits were greater than leaves. These two organs have been revealed as potential sources of Na (≥71.1 ± 0.1 mg / 100 g), K (≥2.6 ± 0,3 mg / 100 g), Mg(≥45.2 ± 0.1 mg / 100 g), Fe (≥30.1 ± 0.1 mg / 100 g), Cu (≥2.0 ± 0.3 mg / 100 g), Zn (≥8.4 ± 0.2 mg / 100 g), Mn (≥0.1 ± 0.04 mg / 100 g), vitamins B1 (≥2.80 ± 0.13 mg / 100 g), B9 (≥0.20 ± 0.02 mg / 100 g) and E (≥6.40 ± 0.10 mg / 100 g) as well as flavonoids (≥ 49.51 ± 0.41 mg / 100 g).This nutritional potential hereby highlighted justifies why D. angolense can be used as food source and a supplementary nutriment in the management of malaria. This study suggests more extensive integration of D. angolense to reduce deficiency nutrients for the population at risk, especially when they face malaria disease.

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Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review

Cited by 49 publications

References 122 publications

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners

Potential Nutrition of Leaves and Fruits of Dialium Angolense Welw. Ex Oliv. (Fabaceae) an Antimalarial Plant From the Eastern of DR Congo

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