Protective Effects of Curcumin on Intestinal Damage in Cholestatic Rats

Kanter, Mehmet; Takır, Mümtaz; Mutlu, Hasan; Kanter, Betül; Köstek, Osman; Toprak, Aybala Erek

doi:10.3109/08941939.2015.1088604

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…[ 36 ] Indeed, we found the induction of apoptosis in colonic epithelium in mice from DSS group, and showed that curcumin inhibited this elevation via suppressing the caspase‐3 pathway. Comparable studies have reported that curcumin protects against oxidative stress and apoptosis in the rat intestinal mucosa after bile duct ligation [ 37 ] ; curcumin ameliorates epithelial cell apoptosis and oxidative stress in inflamed colon mucosa in a rat model of ulcerative colitis. [ 38 ]…”

Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice Through Regulating Gut Microbiota

Guo

Geng

et al. 2022

Molecular Nutrition Food Res

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Scope: Curcumin is a natural polyphenol compound with multiple pharmacologic activities. The present study aims to explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its anti-inflammatory, antioxidant, and anti-apoptotic properties, as well as their associations with altered intestinal microbiome. Methods and Results: DSS, i.e., Dextran Sulfate Sodium, (3%) is administered to C57BL/6J mice in the drinking water daily for 6 days in DSS and curcumin groups. Then, mice in curcumin groups are orally administered with 50 or 150 mg kg -1 curcumin for 7 days. On day 13, mice are sacrificed. Results show that oral administration with curcumin relieves macroscopic pathological manifestations, e.g., colon length and histological change. Moreover, it enhances intestinal barrier via increasing expression of tight junction proteins, e.g., occludin, ZO-1, claudin-3; alleviates DSS-induced intestinal apoptosis via suppressing caspase-3 pathway; mitigates intestinal inflammation via inhibiting the MAPK/NF𝜿B/STAT3 pathway. It is also noticed that curcumin is beneficial for modulating abundance of some specific bacteria, including Akkermansia, Coprococcus, Roseburia, and Turicibacter, as well as families such as F16, Enterococcaceae, and Aerococcaceae. Most of the altered bacteria by curcumin are highly correlated with colitis-associated parameters. Conclusion: Curcumin shows therapeutic potential against colitis. It may be served as an alternative medicine or adjuvant therapy in the treatment of colitis.

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Section: Discussionmentioning

confidence: 99%

Curcumin Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice Through Regulating Gut Microbiota

Guo

Geng

et al. 2022

Molecular Nutrition Food Res

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“…The difference in the composition of rats and humans’ bile constituents might serve as a limitation for the extrapolation of animal data to the clinical situation. However, the BDL model has been repeatedly mentioned as an appropriate model for investigating intestinal injury and bacterial LPS translocation to the systemic circulation ( Bedirli et al., 2009 ; Lorenzo-Zuñiga et al., 2006 ; Kanter et al., 2016 ). The occurrence of oxidative stress in the intestinal tissue of human cases of cholestasis/cirrhosis also has been mentioned in previous studies ( Tsiaoussis et al., 2015 ; Assimakopoulos et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction

Ommati

Farshad

Niknahad

et al. 2020

Current Research in Pharmacology and Drug Discovery

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It has been well documented that cirrhosis is associated with the intestinal injury. Intestinal injury in cirrhosis could lead to bacterial lipopolysaccharide (LPS) translocation to the systemic circulation. It has been found that high plasma LPS is connected with higher morbidity and mortality in cirrhotic patients. Therefore, finding therapeutic approaches to mitigate this complication has great clinical value. Several investigations mentioned the pivotal role of oxidative stress in cirrhosis-associated intestinal injury. It has been well-known that the redox balance of enterocytes is disturbed in cirrhotic patients. In the current study, the effects of thiol-reducing agents N-acetylcysteine (NAC) (0.5 and 1% w: v) and dithiothreitol (DTT) (0.5 and 1% w: v) on biomarkers of oxidative stress, tissue histopathological alterations, and LPS translocation is investigated in a rat model of cirrhosis. Bile duct ligation (BDL) surgery was used to induce cirrhosis in male Sprague-Dawley rats. Animals (n = 48; 8 animals/group) were supplemented with NAC and DTT for 28 consecutive days. Significant changes in ileum and colon markers of oxidative stress were evident in BDL rats as judged by increased reactive oxygen species (ROS), lipid peroxidation, oxidized glutathione (GSSG), and protein carbonylation along with decreased antioxidant capacity and glutathione (GSH) content. Blunted villus, decreased villus number, and inflammation was also detected in the intestine of BDL animals. Moreover, serum LPS level was also significantly higher in BDL rats. NAC and DTT administration (0.5 and 1% w: v, gavage) significantly decreased biomarkers of oxidative stress, mitigated intestinal histopathological alterations, and restored tissue antioxidant capacity. Moreover, NAC and/or DTT significantly suppressed LPS translocation to the systemic circulation. The protective effects of thiol reducing agents in the intestine of cirrhotic rats could be attributed to the effect of these chemicals on the cellular redox environment and biomarkers of oxidative stress.

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“…Kanter et al showed that curcumin treatment has a protective effect against intestinal damage induced by bile duct ligation (BDL) where curcumin treatment inhibits BDL-induced oxidative stress, apoptosis, and cell proliferation. 96 Curcumin reduced the expression of pro-apoptotic Bax and stimulated anti-apoptotic Bcl-2 to attenuate 5-fluorouracil-induced apoptosis of intestinal epithelial cells. Consequently, curcumin significantly reversed chemotherapy-induced weight-loss, increase of serum endotoxin and damage to intestinal mucosa structure and Yao et al hypothesized that the clinical administration of Curcumin may improve chemotherapy-induced intestinal dysfunction, thus increasing the clinical efficacy of chemotherapy.…”

Section: Other Intestine-specific Effects Of Curcuminmentioning

confidence: 99%

Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

Ghosh

Wang

et al. 2018

Tissue Barriers

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Curcumin has anti-inflammatory, anti-oxidant and anti-proliferative properties established largely by in vitro studies. Accordingly, oral administration of curcumin beneficially modulates many diseases including diabetes, fatty-liver disease, atherosclerosis, arthritis, cancer and neurological disorders such as depression, Alzheimer's or Parkinson's disease. However, limited bioavailability and inability to detect curcumin in circulation or target tissues has hindered the validation of a causal role. We established curcumin-mediated decrease in the release of gut bacteria-derived lipopolysaccharide (LPS) into circulation by maintaining the integrity of the intestinal barrier function as the mechanism underlying the attenuation of metabolic diseases (diabetes, atherosclerosis, kidney disease) by curcumin supplementation precluding the need for curcumin absorption. In view of the causative role of circulating LPS and resulting chronic inflammation in the development of diseases listed above, this review summarizes the mechanism by which curcumin affects the several layers of the intestinal barrier and, despite negligible absorption, can beneficially modulate these diseases.

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Protective Effects of Curcumin on Intestinal Damage in Cholestatic Rats

Abstract: Curcumin treatment has a protective effect against intestinal damage induced by BDL. The ability of curcumin treatment is to inhibit BDL-induced oxidative stress, apoptosis, and cell proliferation.

Cited by 9 publications

References 33 publications

Curcumin Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice Through Regulating Gut Microbiota

Curcumin Alleviates Dextran Sulfate Sodium‐Induced Colitis in Mice Through Regulating Gut Microbiota

Oral administration of thiol-reducing agents mitigates gut barrier disintegrity and bacterial lipopolysaccharide translocation in a rat model of biliary obstruction

Curcumin-mediated regulation of intestinal barrier function: The mechanism underlying its beneficial effects

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