Protective effects of curcumin against gamma ray induced conformational change of human serum albumin

Kar, Turban; Basak, Pijush; Ghosh, Rajib R.; Bhattacharyya, Maitree

doi:10.1016/j.ijbiomac.2017.02.105

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…Presence of curcumin offered protection to retain the structural properties of this protein. The protective effect of curcumin was significantly higher in low γ-radiation doses (Kar et al 2017). Shabeeb et al (2020) reported that curcumin administration prevented γ-radiation induced injury to the skin by elevation of activities of anti-oxidant enzymes.…”

Section: Effects Of Curcumin Against Gamma Radiationmentioning

confidence: 99%

Radioprotection by curcumin: A mini review

Sruthi

Naidu

2021

J Spices Arom Crops

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Ionizing radiations are detrimental to the biological system. Exposure to ionizing radiations results in many chronic diseases including cancer. It may cause dysfunctions to almost all organs of the body depending on the total dose, duration and site of irradiation. Apart from its bad effect, radiotherapy is now extensively used for the treatment of several kinds of cancers. Still, the key disadvantage in the procedure is that normal cell, in the surrounding area of the tumor, also receiving radiation doses similar to the tumor, leads to undesirable side effects and risk to patients. Curcumin has been found to protect harmful effects of ionizing radiation. So, it can be beneficial during radiotherapy of cancer. Curcumin helps to kill tumor cells effectively by enhancing the effect of radiation. It also protects normal cells against the harmful effects of radiation. Pre clinical studies are expected to lead to clinical trials to prove the potential of this age-old golden spice for treating cancer patients. This review summarizes the protective effect of curcumin against harmful radiations.

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Section: Effects Of Curcumin Against Gamma Radiationmentioning

confidence: 99%

Radioprotection by curcumin: A mini review

Sruthi

Naidu

2021

J Spices Arom Crops

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“…To the best of our knowledge, there has been a persistent lack of studies investigating the antioxidant and radioprotective effect of vitamins C and E on macromolecules such as proteins [ 18 ], although there have been numerous studies performed in vivo [ 19 , 20 , 21 ]. Therefore, in this study, the radioprotection effect of vitamins C and E on 3 Gy dose gamma radiation-induced BSA structural changes were investigated to gain a better understanding of the potential for application of these common dietary ingredients in improving the safety of radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Radioprotective Role of Vitamins C and E against the Gamma Ray-Induced Damage to the Chemical Structure of Bovine Serum Albumin

et al. 2021

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Radioprotective effects of vitamin C and vitamin E as a water-soluble and a lipid-soluble agent, respectively, were investigated at the molecular level during the imposition of gamma radiation-induced structural changes to bovine serum albumin (BSA) at the therapeutic dose of 3 Gy. Secondary and tertiary structural changes of control and irradiated BSA samples were investigated using circular dichroism and fluorescence spectroscopy. The preirradiation tests showed nonspecific and reversible binding of vitamins C and E to BSA. Secondary and tertiary structures of irradiated BSA considerably changed in the absence of the vitamins. Upon irradiation, α-helices of BSA transitioned to beta motifs and random coils, and the fluorescence emission intensity decreased relative to nonirradiated BSA. In the presence of the vitamins C or E, however, the irradiated BSA was protected from these structural changes caused by reactive oxygen species (ROS). The two vitamins exhibited different patterns of attachment to the protein surface, as inspected by blind docking, and their mechanisms of protection were different. The hydrophilicity of vitamin C resulted in the predominant scavenging of ROS in the solvent, whereas hydrophobic vitamin E localized on the nonpolar patches of the BSA surface, where it did not only form a barrier for diffusing ROS but also encountered them as an antioxidant and neutralized them thanks to the moderate BSA binding constant. Very low concentrations of vitamins C or E (0.005 mg/mL) appear to be sufficient to prevent the oxidative damage of BSA.

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