Protective effects of curcumin against liver fibrosis through modulating DNA methylation

Fatty liver mediated by peroxisome proliferator‐activated receptor‐α DNA methylation can be reversed by a methylation inhibitor and curcumin

“…Differences in species might influence methylation potency . The results of our study suggest that curcumin may inhibit DNA methylation at target genes, which is consistent with the results in previous studies …”

“…miRNA‐15, ‐16 and ‐21) and their target genes. Curcumin reversed liver injury by downregulating DNA methylation of a number of genes, including DNA methyltransferase 1 ( DNMT1 ), α‐smooth muscle actin ( α‐SMA ) and collagen type I alpha 1 chain ( Col1α1 ) genes . Our previous study revealed that curcumin alleviated NAFLD by methylation modifications of adiponectin gene .…”

Nutrition and Genetics in NAFLD: The Perfect Binomium

“…Apple polyphenols and red wine extracts as resveratrol and derivates have been shown to epigenetically prevent diet-induced obesity and ameliorate liver injury and cardiac dysfunction [174][175][176][177]. For instance, curcumin acts as a free radical scavenger and hampers lipid peroxidation and oxidative DNA damage.…”

“…In a randomized double-blind placebo-controlled trial, the short-term curcumin administration in NAFLD patients improved hepatic fat content and metabolic profile (trial registration IRCT20100524004010N24) [178]. In addition, it has been demonstrated that curcumin works as an HAT inhibitor specifically targeting p300/CREB-binding proteins [176] and reduces the expression of DMT1 and pro-fibrotic markers (α smooth muscle actin (αSMA), Col1α1) in rodents affected by carbon tetrachloride (CCL4)-induced liver fibrosis, thus exerting hepatoprotective effects on fibrogenic processes [177]. Green tea, rich in polyphenols and catechins, is a natural hypolipidemic, antioxidant and thermogenic agent whose beneficial effects on hepatic steatosis and liver damage have been widely studied in both genetically and dietary induced experimental models of NAFLD/NASH [179][180][181][182][183][184][185].…”

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

“…Likewise, apple polyphenols and pterostilbene (a derivate of resveratrol), prevented diet-induced obesity by regulating the methylation status of genes involved in lipid metabolism [65,88]. Furthermore, it was reported that curcumin exerted protective effects against liver injury and heart failure through modulating DNA methylation patterns and histone modifications of key genes [89,90]. Based on this evidence, it has been proposed that the introduction of these dietary compounds into an “epigenetic diet” could serve as an effective strategy for reducing the incidence of obesity and associated comorbidities [91].…”