Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats

Bilgin, Hakkı Murat; Atmaca, Mukadder; Obay, Basra Deniz; Özekinci, Selver; Taşdemir, Ezel; Ketani, Aydın

doi:10.1016/j.etp.2010.02.006

Cited by 71 publications

(47 citation statements)

References 28 publications

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“…Moreover, modern biochemical analyses have confirmed that the combination of these herbs achieved an ideally synergistic and maximum therapeutic outcome as compared to any component used individually (26). Previous studies reported that A. annual L and G. jasminoides Ellis exhibited antioxidant and anti-inflammatory properties (26)(27)(28)(29); R. Palatum L was proven to ameliorate liver fibrosis (30-32); and S. baicalensis was identified not only to have antioxidant and anti-inflammatory properties but also antifibrosis effects and modulation of the immune response (33,34). The synergistic effect of the various components may explain why YZH exerts somewhat more potent protective effects against ANIT-induced cholestasis than UDCA.…”

Section: Yzh Is Extracted From Four Different Plantsmentioning

confidence: 95%

Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions

Qian

et al. 2015

Pediatr Res

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Background:The treatment of intrahepatic cholestasis has been limited, and development of an effective drug is needed. Clinical studies have shown that Yinzhihuang (YZH), a traditional Chinese decoction, enhances bilirubin clearance. The goal of this study was to determine the protective effect of YZH on experimental intrahepatic cholestasis in young rats and to explore its underlying molecular mechanisms. Methods: Intrahepatic cholestasis in rats was induced by α-naphthylisothiocyanate (ANIT) on days 1 and 8. The rats received YZH, ursodeoxycholic acid (UDCA), or vehicle for 9 d and were killed on either day 3 or day 10. Serum biomarkers, liver histology, and the distribution of protein and mRNA expression of Mrp2 and Bsep were analyzed. results: YZH treatment resulted in decreased levels of serum biomarkers except γ-glutamyl transpeptidase, attenuated liver histological injuries, increased protein expressions of Mrp2 and Bsep, and upregulated expressions of Mrp2 and Bsep mRNAs. The effects of YZH on serum biomarkers (aminotransferase, alanine aminotransferase, and direct bilirubin), liver histology, and Mrp2 mRNA expressions were significantly greater and earlier than those of UDCA. conclusion: Our results suggest that YZH has protective effect against ANIT-induced intrahepatic cholestasis in rats, through upregulation of Mrp2 and Bsep expressions.

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Section: Yzh Is Extracted From Four Different Plantsmentioning

confidence: 95%

Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions

Qian

et al. 2015

Pediatr Res

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“…Vacuolar degeneration, inflammatory cell infiltration, congestion and necrosis was used as criteria. The parameters were graded as follow: 0 = no abnormality, + = mild injury, ++ = moderate injury and +++ = severe injury (Murat Bilgin et al, 2011).…”

Section: Histopathological Studiesmentioning

confidence: 99%

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Essawy¹

2012

J. App. Pharm. Sci.

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The present study was conducted to evaluate the hepatoprotective effects of aqueous seed extract of Nigella sativa (black seed) on carbon tetrachloride (CCl4) induced liver damage in Swiss albino mice. CCl4 (1.9 ml/kg b.w.) was given orally every other day for three weeks. Aqueous suspension of N. sativa seeds (50 mg/kg b.w.) was given orally every other day alternated with CCl4 for three weeks. Blood was collected for the assessment of serum marker enzymes ( ALT, AST ,ALP and LDH) and lipid profile(triglycerides, total cholesterol, HDL and total lipids), while liver tissue was used for histopathological assessment. Serum levels of liver enzymes and lipid contents were significantly increased in animals treated with CCL4 as compared to control. Histopathological observations, also revealed severe damage in the structure of liver tissue in animals intoxicated with CCL4. Combined treatment of CCL4-exposed animals with N.sativa showed marked improvement in both biochemical and histopathological findings. Only LDH did not affect by N. sativa administration.

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“…The compatibility of the different compounds in YCHT and the effect on the absorption of these 19 compounds were investigated (23). Interestingly, dimethylesculetin (D) has been shown to be effective in treating hepatic injury (HI) by exerting hepatoprotectivity, and it contributes directly to the therapeutic effect of YCHT (24). Geniposide (G), a primary component of the fruits of Gardenia jasminoids Ellis, exhibits various pharmacological properties, including antioxidant, anti-inflammatory, and hepato-protective effects (25)(26)(27).…”

mentioning

confidence: 99%

Metabolomics Coupled with Proteomics Advancing Drug Discovery toward More Agile Development of Targeted Combination Therapies

Wang

Zhang

Wang

et al. 2013

Molecular & Cellular Proteomics

143

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To enhance the therapeutic efficacy and reduce the adverse effects of traditional Chinese medicine, practitioners often prescribe combinations of plant species and/or minerals, called formulae. Unfortunately, the working mechanisms of most of these compounds are difficult to determine and thus remain unknown. In an attempt to address the benefits of formulae based on current biomedical approaches, we analyzed the components of Yinchenhao Tang, a classical formula that has been shown to be clinically effective for treating hepatic injury syndrome. The three principal components of Yinchenhao Tang are Artemisia annua L., Gardenia jasminoids Ellis, and Rheum Palmatum L., whose major active ingredients are 6,7-dimethylesculetin (D), geniposide (G), and rhein (R), respectively. To determine the mechanisms underlying the efficacy of this formula, we conducted a systematic analysis of the therapeutic effects of the DGR compound using immunohistochemistry, biochemistry, metabolomics, and proteomics. Here, we report that the DGR combination exerts a more robust therapeutic effect than any one or two of the three individual compounds by hitting multiple targets in a rat model of hepatic injury. Thus, DGR synergistically causes intensified dynamic changes in metabolic biomarkers, regulates molecular networks through target proteins, has a synergistic/ additive effect, and activates both intrinsic and extrinsic pathways. Molecular & Cellular

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Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats

Cited by 71 publications

References 28 publications

Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions

Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

Metabolomics Coupled with Proteomics Advancing Drug Discovery toward More Agile Development of Targeted Combination Therapies

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