Protective effects of Cornus mas fruit extract on carbon tetrachloride induced nephrotoxicity in rats

Haghi, Masoud Es.; Dehghan, Gholamreza; Banihabib, Nafiseh; Zare, Samad; Mikaili, Peyman; Panahi, F

doi:10.4103/0971-4065.133000

Cited by 34 publications

(15 citation statements)

References 30 publications

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“…Similar reports concerning C officinalis are also published (Lee N. H. et al, 2012 ). The protective effect on kidneys is described for both species using comparable animal experimental settings (Yokozawa et al, 2008 ; Jiang et al, 2012 ; Abbasi et al, 2014 ; Es Haghi et al, 2014 ). In particular, the iridoids [loganin ( 1 ) and morroniside ( 8 )] present mainly in the fruits of C. officinalis as well as 7- O -galloyl-D-sedoheptulose ( 120 ) are able to prevent renal damage in diabetic rats (Xu et al, 2006 ; Park et al, 2012a ).…”

Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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Section: Similarities and Differences Of Pharmacological Effects Or Bmentioning

confidence: 99%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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“…[56]. In the kidney injury induced by an injection of carbon tetrachloride, Banihabib et al [8] observed the decrease of antioxidant enzyme activities (SOD, catalase, and GPx) and impairment of renal functions (increased serum creatinine, urea, and uric acid and decreased albumin). Treatment of rats with different doses of CC fruit extract (300 and 700 mg/kg) significantly ameliorated the alterations induced with carbon tetrachloride in lipid peroxidation, antioxidant defences, and biochemical and renal lesions.…”

Section: Effects Of Cornelian Cherry On Atherosclerosismentioning

confidence: 99%

Effects of Cornelian Cherry on Atherosclerosis and Its Risk Factors

Lietava

Beerová

Klymenko

et al. 2019

Oxidative Medicine and Cellular Longevity

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Functional food represents an important alternative management of atherosclerosis, its risk factors, and clinical complications. Atherosclerosis is characterized by microinflammation, formation of atheromatous lipoprotein-rich plaques, and protrombogenic status. Cornelian cherry (Cornus mas L., CC) contains polyphenols influencing all three components of atherosclerosis. Its high antioxidant potential, verified in experimental studies, exhibited a pronounced decrease of inflammatory markers. CC treatment demonstrated a favourable effect on lipid spectrum (comparable with statins), decrease of glycemia, and increase of insulin (comparable with glibenclamide). Polyphenols identified in CC exhibited both direct antiplatelet effects and reduction of platelet hyper-reactivity mediated via attenuation of oxidative stress. The first clinical trials confirmed a clinically relevant decrease of total and low-density lipoprotein cholesterol, triacylglycerols, lipoproteins, amelioration of inflammatory activity, and insulin secretion improvement after the treatment with CC polyphenolic compounds. However, the limitation of published studies is the use of undefined cultivars of CC, their experimental nature, small scale, and missing longitudinal trials. Nevertheless, biochemical properties of CC, hitherto described, predispose its products for the adjuvant management of atherosclerosis.

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“…Corni Fructus has been used to treat various diseases, including vertigo, tinnitus, cardiovascular disease, frequent urination, oxidative stress, and acute myocardial ischemia [ 3 , 5 , 11 ]. Moreover, it also can regulate the immune system [ 12 – 14 ]. Studies have increasingly discovered the natural constituents present in C .…”

Section: Introductionmentioning

confidence: 99%

De novo transcriptomic analysis of leaf and fruit tissue of Cornus officinalis using Illumina platform

Hou

Shi

Li³

et al. 2018

PLoS ONE

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Cornus officinalis is one of the most widely used medicinal plants in China and other East Asian countries to cure diseases such as liver, kidney, cardiovascular diseases and frequent urination for thousands of years. It is a Level 3 protected species, and is one of the 42 national key protected wild species of animals and plants in China. However, the genetics and molecular biology of C. officinalis are poorly understood, which has hindered research on the molecular mechanism of its metabolism and utilization. Hence, enriching its genomic data and information is very important. In recent years, the fast-growing technology of next generation sequencing has provided an effective path to gain genomic information from nonmodel species. This study is the first to explore the leaf and fruit tissue transcriptome of C. officinalis using the Illumina HiSeq 4000 platform. A total of 57,954,134 and 60,971,652 clean reads from leaf and fruit were acquired, respectively (GenBank number SRP115440). The pooled reads from all two libraries were assembled into 56,392 unigenes with an average length 856 bp. Among these, 41,146 unigenes matched with sequences in the NCBI nonredundant protein database. The Gene Ontology database assigned 24,336 unigenes with biological process (83.26%), cellular components (53.58%), and molecular function (83.93%). In addition, 10,808 unigenes were assigned a KOG functional classification by the KOG database. Searching against the KEGG pathway database indicated that 18,435 unigenes were mapped to 371 KEGG pathways. Moreover, the edgeR database identified 4,585 significant differentially expressed genes (DEGs), of which 1,392 were up-regulated and 3,193 were down-regulated in fruit tissue compared with leaf tissue. Finally, we explored 581 transcription factors with 50 transcription factor gene families. Most DEGs and transcription factors were related to terpene biosynthesis and secondary metabolic regulation. This study not only represented the first de novo transcriptomic analysis of C. officinalis but also provided fundamental information on its genes and biosynthetic pathway. These findings will help us explore the molecular metabolism mechanism of terpene biosynthesis in C. officinalis.

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Protective effects of Cornus mas fruit extract on carbon tetrachloride induced nephrotoxicity in rats

Cited by 34 publications

References 30 publications

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Effects of Cornelian Cherry on Atherosclerosis and Its Risk Factors

De novo transcriptomic analysis of leaf and fruit tissue of Cornus officinalis using Illumina platform

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