Protective Effects of Colchicine in an Experimental Rat Endometriosis Model: Histopathological Evaluation and Assessment of TNF-α Levels

Abstract

Colchicine resulted in regression of endometrial implant volumes in experimental rat endometriosis model and decreased peritoneal and tissue TNF-α levels.

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

“…In our study, no significant difference was observed between the pre‐ and post‐treatment implant volumes in the control group, similar to the studies reported in the literature . However, a significant difference was found between the pre‐ and post‐treatment implant volumes in the ALA group.…”

“…Endometrial tissues are normally localized in the pelvis, but they may also be present in ovaries, uterosacral ligament, the pouch of Douglas, or in any part of the body. Endometriosis is an oestrogen‐dependent chronic disease commonly seen in women of active reproductive age . It affects 8–10% of women of reproductive age and may lead to primary or secondary infertility in 30% of these women .…”

The Impact of Endometriosis across the Lifespan of Women: Foreseeable Research and Therapeutic Prospects

“…The second group of compounds that merit research and development for potential application in endometriosis may potentially mitigate both the intraperitoneal and the systemic inflammatory consequences of endometriosis [ 20 , 34 – 39 ]. On one hand, the recent evidence that omega-3 fatty acids may have anti-inflammatory effects in monocytes by acting on the GPR120 receptor [ 38 ] raises the attractive prospect that a dietary or nutritional supplement could be shown to benefit women with endometriosis.…”

Investigational Medical Therapies for Endometriosis: Current Data and Future Trends

“…54 In another publication using the experimental rat model of endometriosis, the study group treated with colchicine (n ¼ 8) was found to have regression of endometrial implant volumes as well as decreased peritoneal and tissue levels of TNF-α when compared with a control group that received saline solution (n ¼ 8). 55 In a nonhuman primate study, TNF inhibition decreased the number of red endometriotic lesions in a baboon model of endometriosis. 56 D'Hooghe et al conducted a study with baboons (n ¼ 14) which were randomly assigned to rhTBP1, placebo, or GnRH antagonist (positive control) and subsequently had menstrual endometrium incubated with phosphate buffering solution (PBS) or rhTBP1 prior to being seeded into the pelvis of subjects to induce endometriosis.…”