Protective effects of Chrysin against memory impairment, cerebral hyperemia and oxidative stress after cerebral hypoperfusion and reperfusion in rats

Shooshtari, Maryam Khombi; Sarkaki, Alireza; Mansouri, Mohammad Taghi; Badavi, Mohammad; Khorsandi, Layasadat; Dehcheshmeh, Mohammad Ghasemi; Farbood, Yaghoob

doi:10.1007/s11011-019-00527-9

Cited by 25 publications

(5 citation statements)

References 48 publications

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“…Flavones. Neuroprotective flavones include apigenin [77,125], apigenin-7-O-β-D-(-6″-p-coumaroyl)-glucopyranoside (APG) [126], vitexin [127], baicalein [82,109], baicalin [94,[128][129][130][131], chrysin [78,132,133], diosmin [134], ginkgetin [135], hispidulin [136], luteolin [95,137,138], luteoloside [139], orientin [140], nobiletin [60,[141][142][143], scutellarin [67,[144][145][146][147], and tricin 7-glucoside [148].…”

Section: Phytochemicals That Exert Neuroprotection In Experimental Ischemic Strokementioning

confidence: 99%

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Wang

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Ischemic stroke is a challenging disease with high mortality and disability rates, causing a great economic and social burden worldwide. During ischemic stroke, ionic imbalance and excitotoxicity, oxidative stress, and inflammation are developed in a relatively certain order, which then activate the cell death pathways directly or indirectly via the promotion of organelle dysfunction. Neuroprotection, a therapy that is aimed at inhibiting this damaging cascade, is therefore an important therapeutic strategy for ischemic stroke. Notably, phytochemicals showed great neuroprotective potential in preclinical research via various strategies including modulation of calcium levels and antiexcitotoxicity, antioxidation, anti-inflammation and BBB protection, mitochondrial protection and antiapoptosis, autophagy/mitophagy regulation, and regulation of neurotrophin release. In this review, we summarize the research works that report the neuroprotective activity of phytochemicals in the past 10 years and discuss the neuroprotective mechanisms and potential clinical applications of 148 phytochemicals that belong to the categories of flavonoids, stilbenoids, other phenols, terpenoids, and alkaloids. Among them, scutellarin, pinocembrin, puerarin, hydroxysafflor yellow A, salvianolic acids, rosmarinic acid, borneol, bilobalide, ginkgolides, ginsenoside Rd, and vinpocetine show great potential in clinical ischemic stroke treatment. This review will serve as a powerful reference for the screening of phytochemicals with potential clinical applications in ischemic stroke or the synthesis of new neuroprotective agents that take phytochemicals as leading compounds.

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Section: Phytochemicals That Exert Neuroprotection In Experimental Ischemic Strokementioning

confidence: 99%

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Wang

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Kaempferol from Trigona spp. (Ranneh et al, 2018); Apigenin (Zhang et al, 2019b;Singh et al, 2021;Yadav et al, 2022); Chrysin (Shooshtari et al, 2020;Al-Haleem et al, 2021;Zhang et al, 2021); Catechin (Ahmed et al, 2021); Caffeic acid (Arshad et al, 2020;Kadar et al, 2022); ferulic acid (Zhang et al, 2019a,b;Park et al, 2022); and 4-hydroxybenzoic acid (Ranneh et al, 2019) from various SHB have been documented for antioxidant and antiinflammatory activities (Vattuone et al, 2007;Suntiparapop et al, 2012;Duarte et al, 2018;Seng and Tang, 2020;Wongsa et al, 2023).…”

Section: Biological and Therapeutic Aspects Of Sbhmentioning

confidence: 99%

Physiochemical, biological, and therapeutic uses of stingless bee honey

Gadge,

Shirsat,

Soumia

et al. 2024

Front. Sustain. Food Syst.

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Stingless bee honey, also known as pot honey, is a unique product that differs from other honey (Apis) in terms of flavor, chemical composition, biological characteristics, and sourness. Raw and by-products made from this honey have substantial use for its diverse health benefits and human dietary requirements. The physiochemical properties of honey from stingless bee mainly rely on nectar sources, geographic locations, climate, bee species, and handling and storage conditions. The honey contains reducing sugars, water, minerals, and ash content, and its characteristic features include color, acidity, pH, electrical conductivity, and viscosity. Further, it contains several biological and therapeutic constituents such as flavonoids, antioxidants, antibacterial, wound-healing, antidiabetic, and anticancer properties, and the Maillard reaction product hydroxymethylfurfural. This review summarizes the literature on the physical and biological properties and therapeutic constituents' use of stingless bee honey. It also highlights the quality standards available worldwide and required modifications in establishing universal standards for promoting this honey.

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“…This is the case for chrysin, a flavone which behaves as an antioxidant and anti-inflammatory compound, preventing neurotoxicity in vitro [ 67 ]. Moreover, oral administration of chrysin three weeks prior to brain ischemia in rats improved sensorimotor and memory parameters, as well as increased hippocampal cell survival in adult male Wistar rats [ 68 ]. The mechanisms by which this flavonoid exerts neuroprotection are varied.…”

Section: Bioactive Compounds With Neuroprotective Effect Against Brai...mentioning

confidence: 99%

A Review on Polyphenols in Salicornia ramosissima with Special Emphasis on Their Beneficial Effects on Brain Ischemia

et al. 2023

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There has been an increasing interest in the consumption of halophytes as a healthy food in the last few years. Salicornia ramosissima is a seasonal Mediterranean halophyte with an interesting profile of bioactive compounds, including more than 60 identified polyphenols with a broad range of biological activities. Accumulating evidence supports the role of dietary polyphenols in the prevention of cardiovascular diseases, such as stroke. Stroke is the second cause of death worldwide and it is estimated that a substantial proportion of stroke incidence and recurrence may be prevented by healthier dietary patterns. Here, we have grouped the phenolic acids and flavonoids identified in S. ramosissima and reviewed their potential protective effect on brain ischemia, which are mostly related to the reduction of oxidative stress and inflammation, the inhibition of cell death pathways and their role in the preservation of the vascular function. Despite the fact that most of these compounds have been reported to be neuroprotective through multiple mechanisms, human studies are still scarce. Given the safe profile of polyphenols identified in S. ramosissima, this halophyte plant could be considered as a source of bioactive compounds for the nutraceutical industry.

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Protective effects of Chrysin against memory impairment, cerebral hyperemia and oxidative stress after cerebral hypoperfusion and reperfusion in rats

Cited by 25 publications

References 48 publications

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications

Physiochemical, biological, and therapeutic uses of stingless bee honey

A Review on Polyphenols in Salicornia ramosissima with Special Emphasis on Their Beneficial Effects on Brain Ischemia

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