Protective effects of chlorogenic acid against ionizing radiation-induced testicular toxicity

Abedpour, Neda; Zeinali, Ahad; Karimipour, Mohammad; Pourheidar, Bagher; Farjah, Gholam Hossein; Abak, Atefe; Shoorei, Hamed

doi:10.1016/j.heliyon.2022.e10798

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…The findings demonstrated CGA's ability to attenuate extensive damage to spermatogenesis, seminiferous tubules, basal lamina, Leydig cells, and sperm parameters induced by irradiation. Additionally, CGA restored MDA levels to near-normal, significantly increased SOD, total antioxidant capacity (TAC), and GSH levels, while significantly reducing the ratio of BAX/Bcl-2 compared to the radiation-only group [156].…”

Section: Adjuvant Role Of Chlorogenic Acid In Radiotherapymentioning

confidence: 98%

“…Despite its effectiveness, radiation treatment poses challenges by damaging or destroying normal cells, particularly skin cells, leading to severe dermatological issues and even carcinogenesis [154]. Additional side effects encompass testicular tissue damage during pelvic cancer treatment, DNA damage to blood lymphocytes, and chromosomal damage to healthy cells overall [102,155,156]. While advanced radiotherapy techniques such as intensity-modulated radiotherapy aim to minimize toxicity, some patients still encounter adverse effects [153].…”

Section: Adjuvant Role Of Chlorogenic Acid In Radiotherapymentioning

confidence: 99%

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Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment

Cortez,

Villegas,

Burgos

et al. 2024

IJMS

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Chemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors’ resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals effectively. This review is a summary of current information about CGA, including its natural sources, biosynthesis, metabolism, toxicology, role in combatting chemoresistance, and protective effects against chemotherapy-induced toxicity. It also emphasizes the potential of CGA as a pharmacological adjuvant in cancer treatment with drugs such as 5-fluorouracil, cisplatin, oxaliplatin, doxorubicin, regorafenib, and radiotherapy. By analyzing more than 140 papers from PubMed, Google Scholar, and SciFinder, we hope to find the therapeutic potential of CGA in improving cancer therapy.

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Section: Adjuvant Role Of Chlorogenic Acid In Radiotherapymentioning

confidence: 98%