Protective effects of Chlorella vulgaris in lead-exposed mice infected with Listeria monocytogenes

Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella

“…This involves pathophysiologic alterations in the stem cells and their microenvironment, enveloping extracellular matrix and stromal cells, in addition to local and systemic chemokine production [6]. Of importance here are our previous studies showing the relevance of the restoration of both the myelosuppression and the increased splenic EMH for recovering the homeostatic balance in the immunocompromised host, as observed during chronic inflammatory states such as infection and tumors [7][8][9][10][11][12][13][14][15][16].…”

“…Our previous studies demonstrate a significant recovery in the reduced number of myeloid progenitor cells (CFU-GM) in the bone marrow of immunosuppressed host, in consequence of biologically active cytokine release, which was observed in several experimental models of psychogenical and physical stress [7,11,26,[28][29][30][32][33][34][35][36]. These results demonstrated that Chlorella up-regulates the production of colony-stimulating factors in the same manner as for CFU-GM, leading to appropriate production Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella and efficient mobilization of early immune cells, which are crucial to the performance of the surveillance as well as the effector functions of the immune system.…”

“…In this context, Chlorella, a microscopic single-celled freshwater alga containing all the ingredients necessary to promote human health [21] has emerged as an alternative agent against obesity-related complications [22,23]. Chlorella is called an adaptogen, meaning it helps protect the body against various stresses, including physical and psychogenic [7,[24][25][26][27][28][29][30][31][32].…”

“…These results demonstrated that Chlorella up-regulates the production of colony-stimulating factors in the same manner as for CFU-GM, leading to appropriate production Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella and efficient mobilization of early immune cells, which are crucial to the performance of the surveillance as well as the effector functions of the immune system. Importantly, the ability of the alga to reverse both the myelosuppression and the splenic EMH was related to its ability to recover the homeostasis [7,11,26,30,33].…”

Metabolic and motor activity effects of microalgae (Chlorella vulgaris) in laboratory mice

“…В настоящее время зеленые водоросли применяются при лечении гипертензии и модуляции иммунных реакций человека (Merchant, Andre, 2001;Lin et al, 2005;Yang et al, 2006;An et al, 2010). Экстракты хлореллы используются при различных методах терапии опухолей (Tanaka et al, 1998) и бактериальных инфекций (Ibusuki, Minamishima, 1990;Queiroz et al, 2003;Santoyo et al, 2010), продемон-стрирована их способность повышать выработку IFNγ и IL2, а также активировать клетки Th1 для укрепления иммунной системы и иммунной защиты . Показано, что эти водоросли могут затормозить процессы оксидативного стресса, тем самым подавляя наработку провоспалительных медиаторов в макрофагах и печени (Lee et al, 2003).…”