Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

Emanuelli, Tatiana; Augusti, Paula Rossini; Roehrs, Miguel

doi:10.1002/9781119158042.ch16

Cited by 5 publications

(2 citation statements)

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“…Research studies have reported that carotenoids may provide a variety of potential health-promoting functions (Yuan et al , 2003) as they can strengthen the ability of immune system and help the reproductive system to function properly (Handelman, 2001; Lo et al , 2013). Therefore, these pigments have been used in the prevention or protection against diseases such as cardiovascular diseases, cancer, chronic respiratory diseases and diabetes mellitus (Emanuelli et al , 2017). All carotenoids are derivatives of lycopene, which is represented by the formula C 40 H 56 , having a long central chain of 11 conjugated double bonds in the E (trans) configuration (Kaczor et al , 2016).…”

Section: Introductionmentioning

confidence: 99%

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Sharma

Dhiman

Attri

2020

PRT

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Purpose Internal fluffy portion along with fibrous strands of ripe pumpkin is considered as waste in processing industries though it contains sufficient amount of ß-carotene pigment. The purpose of this paper is to use the leftover fluffy portion of ripe pumpkin (Cucurbita maxima) after the use of its flesh for the purpose of processing. Design/methodology/approach The data were analyzed statistically by following a complete randomized design (CRD). All analysis were performed using the software OPSTAT. Findings One hour pre-enzymatic treatment before solvent extraction showed significant improvement in extraction yield in comparison to the isolation of ß-carotene pigment through solvent only. Temperature time combination was optimized as 40°C for 2 h during solvent extraction to obtain maximum yield irrespective of the type of extraction method used. Practical implications Extracted carotene pigment can further be used as a natural food colorant in processed food products not only to enhance the color appeal but also it improves the nutritional value of the product as ß-carotene acts as a precursor of vitamin A. Social implications Coloring agents of natural origin are becoming famous among society due to their health benefits. Consumers are becoming reluctant to use synthetic colors because of the undesirable allergic reactions caused by them, so carotene bio-pigment produced is a natural coloring compound with wide application in the food sector. Originality/value Even though few researchers have worked on the extraction of carotene pigment from pumpkin, but no researcher has reported the use of a waste fluffy portion of C. maxima for extraction of ß-carotene pigment.

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Section: Introductionmentioning

confidence: 99%

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Sharma

Dhiman

Attri

2020

PRT

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“…Dietary antioxidants play an important role in the prevention of cardiovascular diseases, where carotenoids have a distinguished place [ 10 – 12 ]. Lycopene, which is found at high concentrations in tomatoes, has a high antioxidant capacity and is among the most studied carotenoids.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu²⁺-Induced OxidationEx Vivo

Conte

Somacal

Nichelle

et al. 2019

Journal of Nutrition and Metabolism

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Lycopene-based medications and supplements have been developed to prevent atherosclerosis, primarily because of their ability to decrease low-density lipoprotein (LDL) oxidation. Bixin and norbixin are carotenoids found in the seeds of annatto (Bixa orellana) and are colorants widely used by the food industry. Some studies have already demonstrated that these compounds have antioxidant and antiatherogenic potential in vitro and in animal models, but there is no evidence supporting the effects of their long-term or short-term consumption by humans. The aim of this study was to evaluate the effects of short-term intake of annatto carotenoids on biochemical and oxidative stress biomarkers as well as on the susceptibility of LDL oxidation in healthy individuals, using lycopene as a positive control. The effect of daily supplementation (0.05 mg/kg of body weight (b.w.)) with bixin, norbixin, lycopene, or placebo for 7 days was evaluated in a randomized, controlled crossover study in 16 healthy volunteers (8 men and 8 women). The susceptibility of LDL to Cu2+-induced oxidation ex vivo, biochemical parameters, and oxidative stress biomarkers were evaluated. No treatment affected biochemical parameters or most oxidative stress biomarkers. However, bixin reduced the oxidation rate of the LDL lipid moiety (−275%, p<0.1) and nitric oxide metabolites (NOx) (−460%, p<0.1), compared to the placebo group. Moreover, we observed that the changes in these parameters were positively associated, supporting the hypothesis that bixin decreases the susceptibility of LDL to Cu2+-induced oxidation by decreasing NOx levels, probably by downregulating the inducible nitric oxide synthase.

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Optimization of enzyme aided pigment extraction from pumpkin (Cucurbita maxima Duch) using response surface methodology

Sogi

Sharma

2022

Food Measure

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Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

Cited by 5 publications

References 248 publications

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu²⁺-Induced OxidationEx Vivo

Optimization of enzyme aided pigment extraction from pumpkin (Cucurbita maxima Duch) using response surface methodology

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Protective Effects of Carotenoids in Cardiovascular Disease and Diabetes

Cited by 5 publications

References 248 publications

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Utilization of internal waste fluffy portion of Cucurbita maxima for extraction of ß-carotene pigment

Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu2+-Induced OxidationEx Vivo

Optimization of enzyme aided pigment extraction from pumpkin (Cucurbita maxima Duch) using response surface methodology

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Short-Term Bixin Supplementation of Healthy Subjects Decreases the Susceptibility of LDL to Cu²⁺-Induced OxidationEx Vivo