Protective effects of Camellia japonica flower extract against urban air pollutants

Kim, Minkyung; Son, Dahee; Shin, Seoungwoo; Park, Deokhoon; Byun, Sang Yo; Jung, Eunsun

doi:10.1186/s12906-018-2405-4

Cited by 28 publications

(20 citation statements)

References 38 publications

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“…In addition to oxidation by exogenous ROS, endogenous ROS can target polyunsaturated fatty acids (PUFAs) from cell membranes, leading to the generation of reactive aldehyde byproducts like malondialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE) [211], commonly used as biomarkers for oxidative stress [212,213]. Skin exposure to PM was found to induce lipid peroxidation, as well as elevated levels of reactive aldehyde byproducts [119,123,128,133,145,168,175,177,[182][183][184]. These reactive aldehydes can, in turn, react with amino acid residues in proteins, resulting in the formation of carbonylated proteins [214], which were also detected in the skin upon treatment with PM [123, 168-171, 175, 182-184].…”

Section: Pm-induced Oxidative Stress Results In Lipid Protein and Dmentioning

confidence: 99%

“…In another study, the inhibition of the AhR with benzylidene dimethoxydimethylindanone in PM-treated keratinocytes and fibroblasts, resulted in decreased transcription of one of its target genes CYP1A1 and in a decreased subsequent pro-inflammatory response by a decrease in MMP-1 protein expression [172]. Camellia japonica flower extract was shown to have antioxidant properties in human fibroblasts by decreasing PM-induced intracellular ROS levels and subsequently inhibiting AhR activity and CYP1A1 transcription [119]. In addition, this extract has shown to protect from PM-induced lipid peroxidation in an ex vivo human skin model [119].…”

Section: Protective Solutions Against Pm-induced Skin Damagementioning

confidence: 99%

“…Upon binding to its ligand, the AhR translocates from the cytoplasm to the nucleus, where it forms a dimer with the AhR nuclear translocator (ARNT) [202]. PM induces the nuclear translocation of AhR in vitro [119,124,171,172,178]. The AhR/ARNT complex binds to conserved promoter regions containing the xenobiotic response element (XRE), promoting the transcription of several groups of target genes, such as from the phase I metabolism (e.g., cytochrome P450 family 1 subfamily A member 1, CYP1A1, CYP1A2, and CYP1B1), the phase II metabolism (e.g., UDP glucuronosyltransferase family 1 member A complex locus, UGT1A and glutathione S-transferase A1, GSTA1) and a gene for the arylhydrocarbon receptor repressor (AhRR) [203].…”

Section: Pm Triggers Exogenous and Endogenous Ros Formationmentioning

confidence: 99%

“…CYP enzymes can metabolize PAHs, and the formed metabolites can induce cell damage either by the formation of DNA, protein adducts, or the generation of ROS [195,[204][205][206][207][208]. Indeed, PM upregulates the CYP enzyme mRNA and protein expression in vitro and in vivo [119,128,129,134,135,139,141,167,171,172,178,187]. Other ROS producing enzymes are the members of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) family [209].…”

Section: Pm Triggers Exogenous and Endogenous Ros Formationmentioning

confidence: 99%

See 3 more Smart Citations

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

118

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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Section: Pm-induced Oxidative Stress Results In Lipid Protein and Dmentioning

confidence: 99%

Section: Protective Solutions Against Pm-induced Skin Damagementioning

confidence: 99%

Section: Pm Triggers Exogenous and Endogenous Ros Formationmentioning

confidence: 99%

Section: Pm Triggers Exogenous and Endogenous Ros Formationmentioning

confidence: 99%

See 2 more Smart Citations

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

118

116

View full text Add to dashboard Cite

show abstract

“…Finally, the role of Sophora japonica in Chinese Herbal Traditional Medicine is widely known, and numerous biological activities, such as antioxidant, anti-bacterial, anti-allergic, and anti-inflammatory, have been reported [31]. In addition, the photoprotective and anti-pollution effects of Sophora japonica have also been studied [32,66]. nitrosamine injuries and subsequent diseases [68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Nobile¹,

Schiano²,

Peral³

et al. 2020

Preprint

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Repeated air pollution exposure is one of the major threats to skin health. Air pollution causes skin damage and accelerates skin ageing mainly through oxidative stress mechanisms. Since it is difficult to minimize skin exposure from air pollutants, especially in urban areas, strategies to protect the skin are needed. On the other hand, plant phenolic compounds have been found to be effective in attenuating cellular oxidative stress and inflammation induced by different air pollutants. Therefore, we conducted a 12-week randomized, placebo-controlled, double blind study to assess the efficacy of a polyphenol-enriched dietary supplement (comprised of olive leaf, lemon verbena, rosemary and Sophora japonica extracts) in reducing pollution-induced oxidative stress and in improving different skin parameters related to skin ageing of Caucasian and Asian volunteers living in a polluted urban European area (Milan). One hundred healthy women were recruited and randomized in the placebo or in the test dietary supplement treatment arms. To assess the efficacy of the dietary supplement, the total antioxidant capacity on saliva (FRAP) was determined, as well as the oxidative damage on skin (lipoperoxides content), the skin moisture (corneometry), the trans-epidermal water loss (Tewameter), the skin radiance and the skin colour, (spectrophotometry), the skin elasticity (cutometry), the skin sebum content (sebumeter), and the skin roughness (image analysis). As a result, both inter-group and intra-group analysis proved that the dietary supplement improved all clinical and biochemical monitored parameters, in both Caucasian and Asian individuals. In conclusion, the results of the study indicate a reduced oxidative stress-induced skin damage in both Asian and Caucasian women living in a polluted urban area.

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Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

Cho

Kim²,

Paek³

et al. 2021

FEBS Open Bio

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Camellia japonica L. is a flowering tree with several medicinal and cosmetic applications. Here, we investigated the efficacy of C. japonica placenta extract (CJPE) as a potential therapeutic agent for promotion of hair growth and scalp health by using various in vitro and in vivo assays. Moreover, we performed transcriptome analysis to examine the relative expression of human follicle dermal papilla cells (HFDPC) in response to CJPE by RNA‐sequencing (RNA‐seq). In vitro assays revealed upregulation of the expression of hair growth marker genes in HFDPC after CJPE treatment. Moreover, in vivo clinical tests with 42 adult female participants showed that a solution containing 0.5% CJPE increased the moisture content of the scalp and decreased the scalp's sebum content, dead scalp keratin, and erythema. Furthermore, RNA‐seq analysis revealed key genes in HFDPC which are associated with CJPE. Interestingly, genes associated with lipid metabolism and cholesterol efflux were upregulated. Genes upregulated by CJPE are associated with several hormones, including parathyroid, adrenocorticotropic hormone, α‐melanocyte‐stimulating hormone (alpha‐MSH), and norepinephrine, which are involved in hair follicle biology. Furthermore, some upregulated genes are associated with the regulation of axon guidance. In contrast, many genes downregulated by CJPE are associated with structural components of the cytoskeleton. In addition, CJPE suppressed genes associated with muscle structure and development. Taken together, this study provides extensive evidence that CJPE may have potential as a therapeutic agent for scalp treatment and hair growth promotion.

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Protective effects of Camellia japonica flower extract against urban air pollutants

Cited by 28 publications

References 38 publications

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Antioxidant and Reduced Skin Ageing Effects of A Polyphenol-Enriched Dietary Supplement in Response to Air Pollution: A Randomized, Double-Blind, Placebo-Controlled Study

Gene expression profile of human follicle dermal papilla cells in response to Camellia japonica phytoplacenta extract

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