Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus

Antioxidant effect of phycocyanin on oxidative stress induced with monosodium glutamate in rats

“…Farombi and Onyema (2006) showed significant reduction of the TBA levels of the rats treated with monosodium glutamate, with simultaneous administration of vitamin C, vitamin E and queracetin. Rimbau et al (1999) reported the antioxidant potential of the protein Cphycocyanin extracted from S. platensis and showed that the metabolites of this protein had the ability to cross the blood-brain barrier, thereby conferring a protective effect of oxidative stress on the hippocampus of the rats. Table 2 presents the results on the effect of shulfhydryl groups for the animals submitted to different treatments.…”

Effect of microalga Spirulina platensis (Arthrospira platensis) on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia

“…1). However, Rimbau et al (1999), who used Cphycocyanine, protein derived from Spirulina platensis, for testing the antioxidant potential, demonstrated that metabolites from that protein had the ability to pass the blood-brain barrier, offering protective effect against oxidative stress on rats` hippocampus. Miranda et al (1998) also described an inhibition of lipoperoxidation by Spirulina in experiments in vitro with brain tissue and in vivo with rat plasma.…”

Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders

“…44 C-phycocyanin was repeatedly administered orally in a dose of 100 mg/kg (roughly equivalent to 5 mg/kg PCB), 24 hours, 16 hours, and 1 hour prior to injection of kainite. The rats were sacrificed one week later, and indirect markers of hippocampal neuronal death were assessed -markers indicative of microglial and astroglial activation.…”