Protective effects of aucubin against nonylphenol-induced liver toxicity by improving biochemical, inflammatory and histopathological indices

Rehman, Asad Ur; Tahir, Arfa; Ehsan, Nazia; Ijaz, Muhammad Umar; Afsar, Tayyaba; Almajwal, Ali; Alruwaili, Nawaf W.; Hasan, Zafarul; Amor, Houda; Razak, Suhail

doi:10.1016/j.jksus.2022.102033

Cited by 9 publications

(2 citation statements)

References 37 publications

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“…As previously mentioned, the spermatogenic membranes are stuffed with PUFAs and therefore, they have tendency to undergo lipid peroxidation 12 . Lipid peroxidation consists of a cascade of free radical-mediated chain reactions, in which peroxidation of membranous lipids distorts the integrity of macromolecules, such as DNA, proteins, nucleic acid and lipids, thereby causing cellular damage 44 . Summing up, the escalation of oxidative burden due to arsenic intoxication was evident by the reduction in activity of CAT, SOD, GPx, GSR, and GSH level.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

Ijaz

Haider

Tahir

et al. 2023

Sci Rep

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Arsenic is one of the most hazardous environmental contaminants, which adversely affects the dynamics of male reproductive system. Fisetin (FIS) is a bioactive flavonoid, which is known to exert strong antioxidative effects. Therefore, the current research was planned to evaluate the alleviative efficacy of FIS against arsenic-induced reproductive damages. Forty-eight male albino rats were divided into 4 groups (n = 12), which were treated as follows: (1) Control, (2) Arsenic-intoxicated group (8 mg kg−1), (3) Arsenic + FIS-treated group (8 mg kg−1 + 10 mg kg−1), and (4) FIS-treated group (10 mgkg−1). After 56 days of treatment, the biochemical, lipidemic, steroidogenic, hormonal, spermatological, apoptotic and histoarchitectural profiles of rats were analyzed. Arsenic intoxication reduced the enzymatic activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GSR), in addition to glutathione (GSH) level. Conversely, the levels of thiobarbituric acid reactive substance (TBARS) and reactive oxygen species (ROS) were increased. Moreover, it escalated the level of low-density lipoprotein (LDL), triglycerides and total cholesterol, while declining the level of high-density lipoprotein (HDL). Furthermore, steroidogenic enzymes expressions, 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, steroidogenic acute regulatory protein (StAR), cholesterol side-chain cleavage enzyme (CYP11A1) and 17α-hydroxylase/17, 20-lyase (CYP17A1), were found to be reduced, which brought down the level of testosterone. Besides, the levels of gonadotropins (LH and FSH) were decreased. Additionally, a decline in sperm mitochondrial membrane potential (MMP), motility, epididymal sperm count and hypo-osmotic swelling (HOS) coil-tailed sperms was observed, whereas the dead sperms and structural damages (head, midpiece and tail) of sperms were escalated. Moreover, arsenic exposure up-regulated the mRNA expressions of apoptotic markers, namely Bax and caspase-3, whereas lowered the expression of anti-apoptotic marker, Bcl-2. In addition, it induced histoarchitectural changes in testes of rats. However, FIS treatment resulted in remarkable improvements in testicular and sperm parameters. Therefore, it was inferred that FIS could serve as a therapeutic candidate against arsenic-generated male reproductive toxicity attributing to its anti-oxidant, anti-lipoperoxidative, anti-apoptotic, and androgenic efficacy.

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Section: Discussionmentioning

confidence: 99%

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

Ijaz

Haider

Tahir

et al. 2023

Sci Rep

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“…[22] Meanwhile, its active ingredient aucubin also has anti-inflammatory and antioxidant pharmacological effects. [23] Pyrola extract inhibits phosphorylation of p38 MAPK and NF- κ B, inhibits the expression of inducible nitric oxide synthase inducible nitric oxide synthase, iNOS and exerts anti-inflammatory effects. [24] Paeoniae alba has obvious analgesic, anti-inflammatory and immune regulating effects, and its active ingredient paeoniflorin can downregulate the NLRP3 inflammasome pathway to reduce inflammation, [25] has a 2-way regulatory effect on the value-added of immune cells, and can reduce the production and release of prostaglandin E2 in the cerebral cortex, [26] and is often used clinically to treat and relieve various types of pain and immune disorders.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of Tongdu Shujin decoction in the treatment of ankylosing spondylitis with cold-dampness obstruction type: Study protocol for a randomized controlled trial

Wang

et al. 2023

Medicine

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Background: Ankylosing spondylitis (AS) has a high incidence, and severe cases can lead to spinal deformity and even joint fusion, which causes a huge burden on patients life, work and psychology. Tongdu Shujin decoction (TDSJ) has a definite effect in the treatment of ankylosing spondylitis, so we designed a randomized controlled trial to observe the efficacy of TDSJ in the treatment of AS, and to evaluate its safety. Methods: In this randomized controlled trial, 80 eligible patients were randomly assigned in a 1:1 ratio to a treatment group TDSJ and a control group (celecoxib capsules in combination with thalidomide tablets) for 8 weeks. Visual analogue scale, bath ankylosing spondylitis disease activity index, bath ankylosing spondylitis functional index, and traditional Chinese medicine syndrome scores will be used as primary indicators. Erythrocyte sedimentation rate, C-reactive protein, spinal mobility (figure-ground distance, occipital tubercle-wall distance, Schober test) will be used as secondary indicators. Vital signs (respiration, heart rate, body temperature, blood pressure, electrocardiogram), blood routine, urine routine, stool routine, liver function, and renal function will be used as safety indicators. The primary and secondary indicators will be detected at 0th and 8th week, while safety indicators at 0th, 4th, and 8th week. Discussion: This study will provide high-quality clinical evidence for the efficacy and safety of TDSJ in the treatment of AS.

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Understanding the impact of soil components on the environmental existence of Nonylphenol:From the perspective of soil aggregates

Li,

Lv,

et al. 2024

Environmental Research

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Protective effects of aucubin against nonylphenol-induced liver toxicity by improving biochemical, inflammatory and histopathological indices

Cited by 9 publications

References 37 publications

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

Mechanistic insight into the protective effects of fisetin against arsenic-induced reproductive toxicity in male rats

Clinical study of Tongdu Shujin decoction in the treatment of ankylosing spondylitis with cold-dampness obstruction type: Study protocol for a randomized controlled trial

Understanding the impact of soil components on the environmental existence of Nonylphenol:From the perspective of soil aggregates

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