Protective Effects of Aqueous Extract of <i>Baillonella toxisperma</i> Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats

Wego, Marius Trésor; Kamani, Sylviane Laure Poualeu; Miaffo, David; Nchouwet, Moise Legentil; Kim, Albert; Ngnokam, Sylvie Lea Wansi

doi:10.1155/2019/8075163

Cited by 10 publications

(7 citation statements)

References 14 publications

(15 reference statements)

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“…In rats treated with dexamethasone alone Alanine Aminotransferase (ALT) activity was elevated, as well as relative liver weight, this indicated a change in hepatic function and presence of hypertrophy, due to the toxic effects of dexamethasone. These results are similar to those of Wego et al [23], who investigated the preventive impact of Baillonella toxisperma bark aqueous extract on dexamethasone-induced insulin-resistant rats. In contrast to the control group, the activity of Aspartate Aminotransferase (ASAT) was considerably higher in rats treated with dexamethasone.…”

Section: Discussionsupporting

confidence: 91%

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Kepta¹,

Medou²,

Nyunaï³

et al. 2021

GSC Adv. Res. Rev.

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This study aimed to evaluate the effect of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin-resistant male rats. Firstly, a phytochemical screening of the aqueous extract was carried out. Thereafter, using acute and subacute studies (11 days), the effect of the extract (200 mg/kg and 400 mg/kg) was evaluated on dexamethasone-induced hyperglycemic rats. Glycemia was measured before and after treatment in both studies. Histological examinations for isolated liver, kidneys, and pancreas were performed, body and the weight of some internal organs was determined. The biochemical assay in the blood samples was performed only for the subacute study. Phytochemical analysis revealed that the extract contains phenolic compounds, flavonoids, anthocyanins, saponins, gallic tannins, coumarins, and anthraquinones. In both studies, Schumanniophyton magnificum stem bark aqueous extract reduced the glucose blood Area under the Curve produced by dexamethasone injection. The extract, as well as glibenclamide significantly lowered the dexamethasone-induced increase in transaminases activities and uric acid concentration. Superoxide dismutase activity increased in all extract and glibenclamide groups compared to the dexamethasone group. The extract effect on the glutathione concentration was dose-dependent (p < 0.05 and p < 0.001 respectively). The histology of organs from rats treated with dexamethasone revealed hepatic cytolysis, leukocyte infiltration, and islet hypotrophy. The extract nd glibenclamide-treated groups had fewer or no anomalies observed with dexamethasone administration. Aqueous extract of S. magnificum stem bark protects against dexamethasone-induced pancreatic and hepatorenal abnormalities, probably due to the antioxidant properties of the chemical groups present in this extract.

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Section: Discussionsupporting

confidence: 91%

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Kepta¹,

Medou²,

Nyunaï³

et al. 2021

GSC Adv. Res. Rev.

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“…In the current study, the significant decrease in antioxidant levels and the increased lipid peroxidation in the Dexa-treated rats showed a positive correlation with the increased insulin resistance, as evident from the significant increase in FBG, insulin, and HOMA-IR levels, also accompanied by a significant reduction in the HOMA-β level. Dexa-induced insulin resistance was investigated in several tissues by different mechanisms, including the inhibition of glucose uptake and the reduction of glucose oxidation with increasing proteolysis, lipolysis, steatosis, gluconeogenesis, and hyperglycemia [ 95 , 96 , 97 , 98 ]. Studies have demonstrated that GC administration at high doses and/or chronic periods (days to weeks) promotes dysregulation of hepatic glucose metabolism, which is directly related to the reduction of insulin action in the liver, which ultimately means hepatic GC-induced insulin resistance [ 99 , 100 ].…”

Section: Discussionmentioning

confidence: 99%

The Synergetic Effect of Egyptian Portulaca oleracea L. (Purslane) and Cichorium intybus L. (Chicory) Extracts against Glucocorticoid-Induced Testicular Toxicity in Rats through Attenuation of Oxidative Reactions and Autophagy

et al. 2022

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Long-term glucocorticoids can alter sperm motility, vitality, or morphology, disrupting male reproductive function. This study scrutinized the synergistic benefits of two Egyptian plants against dexamethasone (Dexa)-induced testicular and autophagy dysfunction in male rats. Phytochemical ingredients and the combination index were estimated for Purslane ethanolic extract (PEE) and Chicory water extract (CWE). Four control groups received saline and 100 mg/kg of each PEE, CWE, and PEE/CWE, daily for 8 weeks. Dexa (1 mg/kg daily for 6 weeks) induced infertility where PEE, CWE, and PEE/CWE were given. Seminal analysis, male hormones, glycemic and oxidative stress markers, endoplasmic reticulum (ER) stress markers (Sigma 1R and GRP78), and autophagy regulators (Phospho-mTOR, LC3I/II, PI3KC3, and Beclin-1, P62, ATG5, and ATG7) were measured. The in vitro study illustrated the synergistic (CI < 1) antioxidant capacity of the PEE/CWE combination. Dexa exerts testicular damage by inducing oxidative reactions, a marked reduction in serum testosterone, TSH and LH levels, insulin resistance, ER stress, and autophagy. In contrast, the PEE and CWE extracts improve fertility hormones, sperm motility, and testicular histological alterations through attenuating oxidative stress and autophagy, with a synergistic effect upon combination. In conclusion, the administration of PEE/CWE has promised ameliorative impacts on male infertility and can delay disease progression.

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“…Dexamethasone (exogenous glucocorticoid) provokes the insulin resistance thereby induces chronic hyperglycemia and other metabolic disorders such as increase neo-glucogenesis from amino acid and glycerol in the liver, and lipolysis in adipocytes 33 . Dexamethasone also acts by inhibiting the gene expression of adiponectin, a hormone produced by adipocytes which promotes insulin resistance through dysfunction of hormon receptor in the liver, muscle and adipose tissue 34,35 . Fortunately, AECT significantly (p <0.05) decreased blood sugar levels of diabetic rats to normal value with a maximum decrease observed with the highest dose of AECT 1250 mg/kg dose.…”

Section: Discussionmentioning

confidence: 99%

Effect of the Aqueous Extract of Clerodendrum Thomsoniae Linn (Verbenaceae) Leaves on Type 2 Diabetic Wistar Rats Induced by the Macapos1 Type Diet and Dexamethasone

et al. 2021

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Aim and objective: Clerodendrum thomsoniae leaves are used in Cameroon to manage diabetes and its related disorders. The study aimed at investigating the antidiabetic effect of the aqueous extract on diet and dexamethasone induced diabetic rats. Methods: Young mature leaves of C thomsoniae were dried, finely powdered and submitted to aqueous extraction. The dehydrated extract was tested in rats at 3 doses 312.5, 625 and 1250 mg/kg based on the local use of the plant. The effect of the extract on the fasting blood glucose in normoglycemic rats and MACAPOS 1 type diet induced diabetic rats, using respectively glibenclamide and metformin as positive control groups, were investigated. Results: AECT significantly reduced blood glucose levels in normoglycemic rats (p<0.05) two hours after administration, from 83±2 mg/dL to 57.39±1.7 mg/dL with the dose of 1250 mg/kg. given the highest reduction rate of 30.86%. In normoglycemic rats 30 minutes after oral glucose overload, the maximum reduction rate was observed with glibenclamide 5 mg / kg and calculated at 49.90% followed by 36.39%, for the extract at 1250 mg / kg. After 30 days of repeated oral administration, AECT produced a reduction on blood glucose levels (p<0.05) in type 2 diabetic rats. This reduction in blood sugar was much more expressed with the dose of 1250mg/kg (73.52±0.71 mg/dL) followed by metformin 38mg/kg (70.21±0.89 mg/dL) as the normal control with no significant difference (P < 0.05). Conclusion: These results show that the antidiabetic activity of AECT can be explained by insulin stimulating effect, also give support to the traditional use of this plant. Peer Review History: Received 11 May 2021; Revised 17 June; Accepted 27 June, Available online 15 July 2021 Academic Editor: Dr. Asia Selman Abdullah, Al-Razi university, Department of Pharmacy, Yemen, asia_abdullah65@yahoo.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Dr. Terhemen Festus Swem, Department of Veterinary Physiology and Biochemistry, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, Benue State, Nigeria, swemfestus422@gmail.com Taha A.I. El Bassossy, Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt, tahachemist2008@gmail.com Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Similar Articles: ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS THE SCOPING REVIEW OF CHINESE AND WESTERN MEDICINE TREATMENT OF DIABETIC FOOT IN ASIA ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS EFFECTS OF EMODIN ON BLOOD GLUCOSE AND BODY WEIGHT IN TYPE 1 DIABETIC RATS

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Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats

Cited by 10 publications

References 14 publications

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

Antihyperglycemic, antioxidant, and organ protective effects of Schumanniophyton magnificum stem bark aqueous extract in dexamethasone-induced insulin resistance rats

The Synergetic Effect of Egyptian Portulaca oleracea L. (Purslane) and Cichorium intybus L. (Chicory) Extracts against Glucocorticoid-Induced Testicular Toxicity in Rats through Attenuation of Oxidative Reactions and Autophagy

Effect of the Aqueous Extract of Clerodendrum Thomsoniae Linn (Verbenaceae) Leaves on Type 2 Diabetic Wistar Rats Induced by the Macapos1 Type Diet and Dexamethasone

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