Protective effects of aloe vera gel (aloe baberdensis Miller) on aluminum chloride-induced reproductive toxicity in male Wistar rats

Abstract

Objective: This study aims at investigating the protective effects of aloe vera gel on aluminum chloride-induced testicular toxicity of adult Wistar rats. Methods: Twenty male Wistar rats were randomly divided into four groups (A, B, C, and D) with five animals per group. Group A serves as the control group and received distilled water (1ml/Kg). Group B received distilled water (1ml/Kg) with 100mg/kg b.wt of aluminum chloride daily. Group C received 100mg/kg b.wt of aluminum chloride with 600mg/kg b.wt of Aloe vera gel daily. Group D received 100mg/kg b.wt of aluminum chloride with 5mg/kg b.wt of vitamin C daily. The animals were fed on standard laboratory animal diet and water ad libitum . Administration was via oral cannula for four weeks. The rats were slaughtered using cervical dislocation. The testes were harvested for seminal, biochemical and histological analysis. Results: The results demonstrate that the administration of aloe vera gel (AVG) is capable of preventing testicular toxicity due to aluminum chloride. Aluminum chloride caused a significant change in the testes and seminal parameters of group B when compared to the control animals. The level of Nitric oxide (NO) increased and the level of Superoxide dismutase (SOD) decreased significantly in rats treated with aluminum chloride. Conclusions: The administration of aloe vera gel showed a preventive response in aluminum-induced testicular toxicity of rats as evidenced by histological and biochemical analysis.

Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine

“…Exposure to AlCl 3 led to significant distortion of the testicular architecture, as previously reported by Pandey and Jain (2013) and Nuhair (2015) in AlCl 3 -exposed animals and confirmed by Khafaga (2017) and Akinola et al (2021). Guo et al (2006) and Berihu (2015) stated that these changes were due to excessive Al deposition in rat sera, testis, and epididymis.…”

Natural Products as Protective Agents for Male Fertility

“…The effects of vitamin C against aluminum chloride toxicity include ameliorated histopathological and sperm parameters, namely counts, concentration, morphology, and motility (increased fast progressive motility and decreased slow progressive motility). Additionally, vitamin C increased SOD activity while decreasing NO activity [65]. Vitamin C co-administration against mercuric chloride toxicity improved histopathological findings, daily sperm production parameters, and final body weight compared to the group treated for mercuric chloride only.…”

Entomotherapeutic Role of Periplaneta americana Extract in Alleviating Aluminum Oxide Nanoparticles-Induced Testicular Oxidative Impairment in Migratory Locusts (Locusta migratoria) as an Ecotoxicological Model

“…Given this fact, the treatment of locusts with PAE could sustain the integrity of sperms against the adverse effects of Al 2 O 3 NPs, and we could therefore presume that the behavior of sperms would return to normal with regard to motility and the fertilization process accordingly. In a similar fashion, different plant extracts, such as curcumin [ 59 ] and Aloe vera gel [ 60 ], exhibited ameliorative and protective effects against the Al- and AlCl 3 -induced reproductive toxicity of Wistar rats. This research raised many questions in need of further investigation.…”