Protective effects of Aloe vera extract on aluminium sulphate induced alterations in serum lipid profi le of male albino rats, Rattus norvegicus

Abstract

The present study suggests that treatment with Aloe vera a medicinal plant belonging to the family-Liliaceae, used in traditional Indian medicine system and its active constituent Aloin has a positive and therapeutic effect in lowering the lipid profi le level in aluminium sulphate exposed rats for a period of 60 to 90 days. Lipid profi le (total cholesterol, triglyceride, HDL and LDL) levels were found to signifi cantly increased (P<0.05) after treatment of Al 2 (So 4) 3 in Group II compared to normal control Group I treated with normal diet. Group III and Group IV animals treated with Al 2 (So 4) 3 and Aloe vera extract and Al 2 (So 4) 3 and Aloin respectively, showed signifi cant decrease in lipid profi le at (P<0.05). The present study also validates that A.vera extract and pure aloin was effective in reducing Al toxicity in lipid profi le (Total Cholesterol, Triglyceride, HDL and LDL) of treatment in the long term 60 and 90 days of aluminium exposed rats.

Histological study on the acute injection of aluminum sulfate on different organs of rats

“…A number of authors have reported administration of aluminum sulphate mediated toxicity in rats [9,10]. Mahor and Ali [11] suggested that rats received aluminium sulphate in a dose of 98 mg/kg of body weight orally for 30 and 60 days has significantly elevated the normal levels of liver enzymes.…”