Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells

Lü, Jing; Cheng, Bijun; Fang, Baochen; Meng, Zhuoqun; Zheng, Yiying; Tian, Xiaochen; Guan, Shuang

doi:10.1016/j.biopha.2017.10.125

Cited by 19 publications

(15 citation statements)

References 34 publications

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“…Indeed, the lowering of total cholesterol, triglycerides, LDL-c levels and increase HDL-c levels induced by the formulation F (1:1) may be due to their richness in phenolic compounds such as phytosterols (found in avocado) in particular the beta-sitosterols which are known to induce a decrease in plasma lipoprotein and cholesterol levels by decreasing cholesterol solubility and absorption across the intestinal barrier [ 6 , 40 , 41 ]. Bioactive compounds of the formulation such as allicin can also increase the activation of AMPK to suppress cholesterol synthesis [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Lipomodulatory and anti-oxidative stress effects of a polyherbal formulation based on garlic and avocado seed extracts on high fat high sucrose diet fed rats

Boris

Ntentie²,

Mary-Ann³

et al. 2022

Metabolism Open

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Section: Discussionmentioning

confidence: 99%

Lipomodulatory and anti-oxidative stress effects of a polyherbal formulation based on garlic and avocado seed extracts on high fat high sucrose diet fed rats

Boris

Ntentie²,

Mary-Ann³

et al. 2022

Metabolism Open

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“…The liver is the main organ to maintain the balance of fat metabolism. The imbalance of anabolism, transport, and catabolism of TG in liver cells is the main factor of fat metabolism disorder and the formation of fatty liver [37,38]. DGAT2 is the main ratelimiting enzyme in the TG synthesis pathway and is highly expressed in both fat and liver [39].…”

Section: Discussionmentioning

confidence: 99%

Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway

Tang

et al. 2020

Journal of Diabetes Research

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Purpose. To investigate the effects of Roux-en-Y gastric bypass (RYGB) surgery on markers of liver mitochondrial dynamics and find new therapeutic basis on obese type 2 diabetes mellitus (T2DM) patients. Materials and Methods. Thirty-two rats were divided into nondiabetic group, diabetic group, sham group, and RYGB group. The Dual-energy X-ray absorptiometry (DEXA) was used to detect short-term curriculum vitae for rat body component and fat and lean mass. Hepatic lipid content and triglyceride levels were detected by Oil Red O staining. Western blotting was used to examine autophagy and mammalian target of rapamycin/P70S6 kinase (mTOR/p70S6K) pathway-related proteins. The carbon dioxide production from the oxidation of [14C] oleate was measured. Plasma glucose was measured by glucose oxidase assay. The insulin and C-peptide were detected. Triacylglyceride (TG) and free fat acid (FFA) in plasma were determined by enzymatic colorimetric assays. Results. RYGB improved metabolic parameters and enhanced plasma GLP-1 level, ameliorated the lipopexia, and increased insulin sensitivity in the liver; RYGB promoted the hepatic autophagy and inhibited the mTOR/p70S6K signaling pathway. GLP-1 reduced fat load and increased fatty acid β-oxidation by activated autophagy to regulate the hepatic lipid pathway through mTOR/p70S6K signaling pathway. Conclusions. RYGB may reduce liver lipid toxicity and improve insulin sensitivity through activating the hepatic fat hydrolysis pathway and inhibiting the liver fat synthesis pathway. However, the transport pathway of liver fat does not play a key role.

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“…In this context, the beneficial effects of allicin involved the modulation of signaling pathways underlying the synthesis or degradation of lipids and carbohydrates. Thus, allicin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), protein kinase A (PKA), and the AMP response element-binding protein (CREB) in a cell culture of hepatic lipotoxicity (HepG2) [ 46 ]. In contrast, allicin decreased the expression of the sterol regulatory element-binding protein 1 (SREBP-1) and the protein SREBP-2.…”

Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning

confidence: 99%

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Sánchez-Gloria

Arellano‐Buendía

Juárez-Rojas

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.

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Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells

Cited by 19 publications

References 34 publications

Lipomodulatory and anti-oxidative stress effects of a polyherbal formulation based on garlic and avocado seed extracts on high fat high sucrose diet fed rats

Lipomodulatory and anti-oxidative stress effects of a polyherbal formulation based on garlic and avocado seed extracts on high fat high sucrose diet fed rats

Roux-en-Y Gastric Bypass in Obese Diabetic Rats Promotes Autophagy to Improve Lipid Metabolism through mTOR/p70S6K Signaling Pathway

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

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